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    ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR
    2.
    发明申请
    ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR 有权
    特异性识别转铁蛋白受体的抗体

    公开(公告)号：US20140114054A1

    公开(公告)日：2014-04-24

    申请号：US14116714

    申请日：2012-05-07

    申请人： Yoshikazu Kurosawa ,  Kazuhiro Morishita ,  Lilin Zhang ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Yukio Sudo ,  Fumiko Nomura ,  Yoshinori Ukai

    发明人： Yoshikazu Kurosawa ,  Kazuhiro Morishita ,  Lilin Zhang ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Yukio Sudo ,  Fumiko Nomura ,  Yoshinori Ukai

    IPC分类号： C07K16/30

    CPC分类号： C07K16/30 ,  C07K16/2881

    摘要： An object of present invention is to provide a complete human anti-human TfR antibody, which specifically recognizes human TfR, inhibits the survival or growth of cancer cells that highly express TfR, and has no immunogenicity to humans. The present invention provides an antibody which specifically reacts with human TfR, wherein the antibody comprises any one of the amino acid sequences shown in SEQ ID NOS: 1-3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, and 115-117, as each of a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2), and a heavy chain third complementarity determining region (VH CDR3).

    摘要翻译： 本发明的目的是提供一种完全人抗TfR抗体，其特异性识别人TfR，抑制高表达TfR的癌细胞的存活或生长，并且对人类没有免疫原性。 本发明提供与人TfR特异性反应的抗体，其中所述抗体包含SEQ ID NO： 31-33,37-39,43-45,49-51,55-57,61-63,67-69,73-75,79-81,85-87,91-93,97-99,103- 105，109-111和115-117，作为重链第一互补决定区（VH CDR1），重链第二互补决定区（VH CDR2）和重链第三互补决定区（VH CDR3） 。