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1.发明授权Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome 失效磷酸盐，包含磷酸盐作为膜组织的脂质体，以及包含脂质体的化妆和脂质体制备
公开(公告)号：US5153000A
公开(公告)日：1992-10-06
申请号：US437099
申请日：1989-11-16
申请人： Yoshiko Chikawa , Katsumi Kita , Mitsuharu Masuda , Tomihiro Kurosaki , Takashi Itoh , Noriko Inoue , Haruya Kato , Takashi Imamura , Yasuo Ishii , Yoshitaka Kokusho , Akira Tsunoda , Shigeaki Kato
发明人： Yoshiko Chikawa , Katsumi Kita , Mitsuharu Masuda , Tomihiro Kurosaki , Takashi Itoh , Noriko Inoue , Haruya Kato , Takashi Imamura , Yasuo Ishii , Yoshitaka Kokusho , Akira Tsunoda , Shigeaki Kato
CPC分类号： C07H11/04 , A61K8/14 , A61K8/556 , A61K9/1271 , A61K9/1272 , A61Q19/00 , C07F9/10 , Y10S977/797 , Y10S977/904 , Y10S977/915 , Y10S977/926
摘要： A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.
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公开(公告)号：US4994581A
公开(公告)日：1991-02-19
申请号：US452419
申请日：1989-12-19
CPC分类号： C07F9/65502 , C07F9/10
摘要： A novel phosphoric ester of the formula (I) ##STR1## wherein, Z represents the following radicals ##STR2## useful as modifiers for amino acids, peptides and proteins which are easily decomposable in living bodies.
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公开(公告)号：US5196186A
公开(公告)日：1993-03-23
申请号：US815225
申请日：1991-12-31
摘要： An alkali metal monoalkylphosphate having a saturated or unsaturated straight-chain or branched hydrocarbon group having from 8 to 32 carbon atoms is described; also described is a process for preparing particles of said alkali metal zinc monoalkylphosphate and cosmetics containing said particles.
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4.发明授权Alkali metal zinc monoalkylphosphate, particles thereof, process for preparing the same, and cosmetic containing the same 失效碱金属锌一烷基磷酸盐，其颗粒，其制备方法以及含有它们的化妆品
公开(公告)号：US5176904A
公开(公告)日：1993-01-05
申请号：US693496
申请日：1991-04-30
摘要： An alkali metal monoalkylphosphate having a saturated or unsaturated straight-chain or branched hydrocarbon group having from 8 to 32 carbon atoms is described; also described is a process for preparing particles of said alkali metal zinc monoalkylphosphate and cosmetics containing said particles.
摘要翻译： 描述具有8至32个碳原子的饱和或不饱和直链或支链烃基的碱金属单烷基磷酸酯; 还描述了制备所述碱金属锌单烷基磷酸盐的颗粒和含有所述颗粒的化妆品的方法。
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5.发明授权Alkali metal zinc monoalkylphosphate, particles thereof, process for preparing the same, and cosmetic containing the same 失效碱金属锌化合物单烷基磷酸酯，其颗粒，其制备方法和包含其的化妆品
公开(公告)号：US5174991A
公开(公告)日：1992-12-29
申请号：US494001
申请日：1990-02-27
摘要： An alkali metal monoalkylphosphate having a saturated or unsaturated straight-chain or branched hydrocarbon group having from 8 to 32 carbon atoms is described; also described is a process for preparing particles of said alkali metal zinc monoalkylphosphate and cosmetics containing said particles.
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公开(公告)号：US4623743A
公开(公告)日：1986-11-18
申请号：US700033
申请日：1985-02-11
CPC分类号： B01F17/0064 , A61K8/06 , A61K8/55 , A61Q19/00 , A61Q19/10 , C07F9/091 , A61K2800/75
摘要： A phosphoric ester of the following formula (I): ##STR1## in which R.sub.1 represents a saturated or unsaturated, linear or branched and substituted or unsubstituted hydrocarbon group having from 8 to 32 carbon atoms, R.sub.2, R.sub.3 and R.sub.4 are the same or different and represent a saturated or unsaturated hydrocarbon group having from 1 to 4 carbon atoms, R.sub.5 represents a hydrogen atom, a saturated or unsaturated hydrocarbon group having from 1 to 4 carbon atoms, and n is an integer of from 0 to 50.The above novel phosphoric acid ester has excellent detergent performance with very low irritations to living body.A manufacturing method of the ester is also disclosed. According to the method, the ester can be prepared from inexpensive, readily available starting materials by a simple procedure in high purity and high yield.
摘要翻译： 下式（I）的磷酸酯：其中R 1表示饱和或不饱和的直链或支链和取代或未取代的具有8至32个碳原子的烃基，R 2，R 3和R 4是 相同或不同，表示具有1至4个碳原子的饱和或不饱和烃基，R5表示氢原子，具有1至4个碳原子的饱和或不饱和烃基，n为0至50的整数。 上述新型磷酸酯具有优异的洗涤性能，对生物体的刺激性极低。 还公开了酯的制造方法。 根据该方法，可以通过简单的方法以高纯度和高产率从廉价的，容易获得的原料制备酯。
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公开(公告)号：US4751320A
公开(公告)日：1988-06-14
申请号：US925384
申请日：1986-10-31
摘要： A novel phosphoric ester represented by the following formula (I): ##STR1## is produced by halogenating the hydroxyl group of a monoalkyl phosphoric acid, reacting the halogenated product with N-benzoyloxycarbonyl serine ester and then removing protecting groups for the carboxyl group and amino group.According to the present production process, the phosphoric ester can be obtained inexpensively at a high yield and high purity. Further, the phosphoric ester has a structure similar to that of the phospholipid and has nitrogen-containing polar groups such as amino group in one molecule, so that it has excellent emulsification ability and moisture keeping function. It is thus useful as emulsifiers, humectants and the like.
摘要翻译： 由下式（I）表示的新型磷酸酯：通过卤化单烷基磷酸的羟基，使卤代物与N-苯甲酰氧基羰基丝氨酸酯反应，然后除去羧基的保护基来制备（I） 组和氨基。 根据本制造方法，可以高产率和高纯度廉价地获得磷酸酯。 此外，磷酸酯具有与磷脂类似的结构，并且在一个分子中具有含氮极性基团如氨基，因此其具有优异的乳化能力和保湿功能。 因此，作为乳化剂，保湿剂等是有用的。
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