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公开(公告)号：US20090118322A1
公开(公告)日：2009-05-07
申请号：US12289748
申请日：2008-11-03
IPC分类号： A61K31/437 , A61P25/00
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
摘要翻译： 式（I）的酰胺化合物[各符号如说明书中所定义]对三叉神经细胞的神经发生具有促进作用，并且该化合物可用作角膜神经发生促进剂，通过促进角膜神经发生促进剂来恢复角膜敏感性 角膜神经发生，以及用于治疗干眼症的药剂。
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公开(公告)号：US20060234922A1
公开(公告)日：2006-10-19
申请号：US10533115
申请日：2003-10-22
IPC分类号： A61K31/4545 , A61K31/454 , A61K38/12 , A61K38/10
摘要： The present invention provides a new type of pharmaceutical agent that recovers corneal sensitivity after corneal surgery or improves the condition of dry eye. Application of a somatostatin receptor agonist is expected to provide an improvement effect on decreased corneal sensitivity after cataract surgery or LASIK surgery, decreased corneal sensitivity and dry eye associated with corneal neurodegeneration such as neuroparalytic keratopathy, corneal ulcer, diabetic keratopathy and the like.
摘要翻译： 本发明提供了在角膜手术后恢复角膜敏感性或改善干眼症状的新型药剂。 预期生长抑素受体激动剂的应用对于白内障手术或LASIK手术后的角膜敏感性降低，与角膜神经变性如神经麻痹性角膜病，角膜溃疡，糖尿病性角膜病等相关的角膜敏感性和干眼症的降低有改善作用。
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公开(公告)号：US20060252765A1
公开(公告)日：2006-11-09
申请号：US10557415
申请日：2005-06-03
IPC分类号： A61K31/501 , A61K31/4745 , A61K31/445 , A61K31/165
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
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公开(公告)号：US07956072B2
公开(公告)日：2011-06-07
申请号：US12289748
申请日：2008-11-03
IPC分类号： A61K31/445 , A61K31/44
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
摘要翻译： 式（I）的酰胺化合物[各符号如说明书中所定义]对三叉神经细胞的神经发生具有促进作用，并且该化合物可用作角膜神经发生促进剂，通过促进角膜神经发生促进剂来恢复角膜敏感性 角膜神经发生，以及用于治疗干眼症的药剂。
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公开(公告)号：US07485654B2
公开(公告)日：2009-02-03
申请号：US10557415
申请日：2005-06-03
IPC分类号： A61K31/445 , A61K31/44
CPC分类号： C07D471/04 , A61K31/165 , A61K31/437 , A61K31/445 , A61K31/4745 , A61K31/501
摘要： The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by promotion of corneal neuritogenesis, and an agent for treating dry eye.
摘要翻译： 式（I）的酰胺化合物[各符号如说明书中所定义]对三叉神经细胞的神经发生具有促进作用，并且该化合物可用作角膜神经发生促进剂，通过促进角膜神经发生促进剂来恢复角膜敏感性 角膜神经发生，以及用于治疗干眼症的药剂。
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公开(公告)号：US20070093513A1
公开(公告)日：2007-04-26
申请号：US10553320
申请日：2004-04-16
IPC分类号： A61K31/517 , A61K31/454
CPC分类号： A61K38/45 , A61K31/454 , A61K31/517 , C12Y304/22054
摘要： The present invention provides a novel pharmaceutical agent for recovering corneal sensitivity after corneal surgery and improving symptoms of dry eye. This pharmaceutical agent is useful for improving decreased corneal sensitivity and dry eye associated with corneal neurodegeneration such as post-cataract operation, post-LASIK operation, post-PRK operation, postkeratoplasty operation, neuroparalytic keratopathy, corneal ulcer, diabetic keratopathy and the like, since it contains a Rho protein inhibitor.
摘要翻译： 本发明提供了用于在角膜手术后恢复角膜敏感性并改善干眼症状的新型药剂。 该药剂可用于改善与角膜神经变性相关的角膜敏感性和干眼症，如白内障术后，LASIK术后，PRK后术后，角膜内成形术，神经麻痹性角膜病，角膜溃疡，糖尿病性角膜病等。 它含有Rho蛋白抑制剂。
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7.发明申请公开(公告)号：US20110212899A1
公开(公告)日：2011-09-01
申请号：US11578796
申请日：2005-04-21
申请人： Yoshiko Takayama , Yoshikuni Nakamura , Yutaka Inoue , Chiho Yabuta , Mitsuyoshi Azuma , Satomi Onoue
发明人： Yoshiko Takayama , Yoshikuni Nakamura , Yutaka Inoue , Chiho Yabuta , Mitsuyoshi Azuma , Satomi Onoue
CPC分类号： A61K38/2278
摘要： It is intended to provide an agent for promoting corneal neuritogenesis containing PACAP, a PACAP derivative or a pharmaceutically acceptable salt thereof, in particular, an agent for promoting corneal neuritogenesis aiming at improving corneal sensitivity, treating dry eye and treating corneal epithelial injury due to an effect of promoting corneal neuritogenesis. This agent for promoting corneal neuritogenesis is useful as a drug for ameliorating reduction in corneal sensitivity following corneal surgeries such as laser keratonomy (LASIK) and corneal grafting or cataract surgery, reduction in corneal sensitivity accompanying corneal neurodegeneration and dry eye symptom and corneal epithelial injury accompanying such reduction in corneal sensitivity. Moreover, it is useful as a drug for ameliorating dry eye symptom, reduction in corneal sensitivity and corneal epithelial injury in patients with dry eye, and a drug for ameliorating corneal epithelial injury and dry eye symptom and reduction in corneal sensitivity accompanying therewith.
摘要翻译： 旨在提供用于促进包含PACAP，PACAP衍生物或其药学上可接受的盐的角膜神经发生的药剂，特别是用于促进角膜神经突发生的药物，其目的在于改善角膜敏感性，治疗干眼症并治疗角膜上皮损伤 促进角膜神经发生的作用。 用于促进角膜神经发生的药物可用作改善角膜手术如角膜手术（LASIK）和角膜移植术或白内障手术后角膜敏感性降低的药物，伴随角膜神经变性和干眼症状以及角膜上皮损伤伴随的角膜敏感性降低 角膜敏感度降低。 此外，它可用作改善干眼症状，减少干眼症患者的角膜敏感性和角膜上皮损伤的药物，以及用于改善角膜上皮损伤和干眼症状以及与之伴随的角膜敏感性降低的药物。
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公开(公告)号：US20060148852A1
公开(公告)日：2006-07-06
申请号：US11366460
申请日：2006-03-03
IPC分类号： A61K31/445
CPC分类号： C07D471/04 , A61K9/0048 , A61K31/00 , A61K31/437 , C07D211/00
摘要： The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.
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公开(公告)号：US07109208B2
公开(公告)日：2006-09-19
申请号：US10474369
申请日：2002-04-11
IPC分类号： A61K31/437 , A61K31/44
CPC分类号： C07D471/04 , A61K9/0048 , A61K31/00 , A61K31/437 , C07D211/00
摘要： The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.
摘要翻译： 本发明提供含有具有Rho激酶抑制活性的化合物的视觉功能障碍改善剂，特别是（R） - （+） - N-（1H-吡咯并[2,3-b]吡啶-4-基）-4- （1-氨基乙基）苯甲酰胺作为有效成分。 该药剂具有视网膜神经节细胞延伸促进作用和视神经细胞再生促进作用的轴突，并且可用于治疗由视网膜中的损伤，缺陷，变性等引起的各种眼病的视觉功能障碍， 视神经
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公开(公告)号：US07696194B2
公开(公告)日：2010-04-13
申请号：US11366460
申请日：2006-03-03
IPC分类号： A61K31/551 , A61K31/4725
CPC分类号： C07D471/04 , A61K9/0048 , A61K31/00 , A61K31/437 , C07D211/00
摘要： The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.
摘要翻译： 本发明提供含有具有Rho激酶抑制活性的化合物的视觉功能障碍改善剂，特别是（R） - （+） - N-（1H-吡咯并[2,3-b]吡啶-4-基）-4- （1-氨基乙基）苯甲酰胺作为有效成分。 该药剂具有视网膜神经节细胞延伸促进作用和视神经细胞再生促进作用的轴突，并且可用于治疗由视网膜中的损伤，缺陷，变性等引起的各种眼病的视觉功能障碍， 视神经
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