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    Pathologic tissue image analyzing apparatus, pathologic tissue image analyzing method, and pathologic tissue image analyzing program
    2.
    发明授权
    Pathologic tissue image analyzing apparatus, pathologic tissue image analyzing method, and pathologic tissue image analyzing program 有权
    病理组织图像分析仪器，病理组织图像分析方法，病理组织图像分析程序

    公开(公告)号：US08594411B2

    公开(公告)日：2013-11-26

    申请号：US13376073

    申请日：2010-06-03

    申请人： Yoshiko Yoshihara ,  Kenji Okajima ,  Akira Saito

    发明人： Yoshiko Yoshihara ,  Kenji Okajima ,  Akira Saito

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0012 ,  G06K9/0014 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： This invention is directed to improvement of the accuracy of cancer differentiation in the pathologic diagnosis using a pathologic tissue image analysis. There are included a stroma area/duct area detecting module for detecting, from a biological tissue image, a duct area on the basis of duct characteristic information indicating the characteristic of ducts included in a tissue area in the biological tissue image; an intraduct cell-nucleus detecting module for extracting, based on a predetermined pigment reference, cell nucleuses included in the detected duct area; and a duct formation evaluating module for calculating a heterotypic degree of each duct on the basis of the distribution state of the cell nucleuses for a predetermined base areas in each duct.

    摘要翻译： 本发明旨在提高使用病理组织图像分析的病理诊断中癌症分化的准确性。 包括基质区域/管道区域检测模块，用于根据生物组织图像中包含在组织区域中的管道的特征的管道特征信息从生物组织图像检测管道区域; 导管细胞核检测模块，用于基于预定的颜料参考提取包括在检测到的管道区域中的细胞核; 以及管道形成评估模块，用于基于每个管道中的预定基区的细胞核的分布状态来计算每个管道的异型度。

    PATHOLOGIC TISSUE IMAGE ANALYZING APPARATUS, PATHOLOGIC TISSUE IMAGE ANALYZING METHOD, AND PATHOLOGIC TISSUE IMAGE ANALYZING PROGRAM
    3.
    发明申请
    PATHOLOGIC TISSUE IMAGE ANALYZING APPARATUS, PATHOLOGIC TISSUE IMAGE ANALYZING METHOD, AND PATHOLOGIC TISSUE IMAGE ANALYZING PROGRAM 有权
    病理组织图像分析装置，病理组织图像分析方法和病理组织图像分析程序

    公开(公告)号：US20120082365A1

    公开(公告)日：2012-04-05

    申请号：US13376073

    申请日：2010-06-03

    申请人： Yoshiko Yoshihara ,  Kenji Okajima ,  Akira Saito

    发明人： Yoshiko Yoshihara ,  Kenji Okajima ,  Akira Saito

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0012 ,  G06K9/0014 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： This invention is directed to improvement of the accuracy of cancer differentiation in the pathologic diagnosis using a pathologic tissue image analysis. There are included a stroma area/duct area detecting module for detecting, from a biological tissue image, a duct area on the basis of duct characteristic information indicating the characteristic of ducts included in a tissue area in the biological tissue image; an intraduct cell-nucleus detecting module for extracting, based on a predetermined pigment reference, cell nucleuses included in the detected duct area; and a duct formation evaluating module for calculating a heterotypic degree of each duct on the basis of the distribution state of the cell nucleuses for a predetermined base areas in each duct.

    摘要翻译： 本发明旨在提高使用病理组织图像分析的病理诊断中癌症分化的准确性。 包括基质区域/管道区域检测模块，用于根据生物组织图像中包含在组织区域中的管道的特征的管道特征信息从生物组织图像检测管道区域; 导管细胞核检测模块，用于基于预定的颜料参考提取包括在检测到的管道区域中的细胞核; 以及管道形成评估模块，用于基于每个管道中的预定基区的细胞核的分布状态来计算每个管道的异型度。

    MODULE FOR DETECTING POORLY DIFFERENTIATED CANCERS AND PATHOLOGICAL IMAGE DIAGNOSIS SUPPORT APPARATUS, PROGRAM AND RECORDING MEDIUM INCLUDING THE SAME
    5.
    发明申请
    MODULE FOR DETECTING POORLY DIFFERENTIATED CANCERS AND PATHOLOGICAL IMAGE DIAGNOSIS SUPPORT APPARATUS, PROGRAM AND RECORDING MEDIUM INCLUDING THE SAME 有权
    用于检测不良的癌症和病理学图像诊断支持装置，程序和记录介质的模块

    公开(公告)号：US20090116723A1

    公开(公告)日：2009-05-07

    申请号：US12265292

    申请日：2008-11-05

    申请人： Kenji Okajima ,  Yoshiko Yamashita ,  Akira Saito

    发明人： Kenji Okajima ,  Yoshiko Yamashita ,  Akira Saito

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127

    摘要： The detection accuracy of poorly differentiated cancers in adenocarcinoma is improved by restricting false detection. Cell nucleus detection means 1 receives a digitized pathological image as an input and extracts the region of a cell nucleus therefrom. Gland duct detection means 2 detects a gland duct structure in the image. Poorly differentiated cancer detection means 4 detects poorly differentiated cancers only in the region other than the gland duct region. False detection rejection means 7 compares the detection density of poorly differentiated cancer in the vicinity of a detection point with a threshold that is predetermined depending on gland duct density in the vicinity of the detection point, at each detection point detected by poorly differentiated cancer detection means 4 and rejects the detection point as a false detection if the detection density of a poorly differentiated cancer is smaller than the threshold.

    摘要翻译： 通过限制假检测可以提高腺癌分化不良的癌症的检测准确性。 细胞核检测装置1接收数字化的病理图像作为输入，并从中提取细胞核的区域。 腺体管检测装置2检测图像中的腺体管结构。 分化不良的癌症检测手段4仅在腺体管区域以外的区域检测分化不良的癌症。 假检测抑制机构7将检测点附近的分化不良的癌症的检测密度与根据检测点附近的腺体密度预先确定的阈值，在低分辨率癌症检测手段检测的各检测点进行比较 4，如果分化不良的癌症的检测密度小于阈值，则将检测点拒绝为假检测。

    Module for detecting poorly differentiated cancers and pathological image diagnosis support apparatus, program and recording medium including the same
    6.
    发明授权
    Module for detecting poorly differentiated cancers and pathological image diagnosis support apparatus, program and recording medium including the same 有权
    用于检测分化不良的癌症和病理图像诊断支持装置，程序和记录介质的模块

    公开(公告)号：US08199998B2

    公开(公告)日：2012-06-12

    申请号：US12265292

    申请日：2008-11-05

    申请人： Kenji Okajima ,  Yoshiko Yamashita ,  Akira Saito

    发明人： Kenji Okajima ,  Yoshiko Yamashita ,  Akira Saito

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127

    摘要： The detection accuracy of poorly differentiated cancers in adenocarcinoma is improved by restricting false detection. Cell nucleus detection means 1 receives a digitized pathological image as an input and extracts the region of a cell nucleus therefrom. Gland duct detection means 2 detects a gland duct structure in the image. Poorly differentiated cancer detection means 4 detects poorly differentiated cancers only in the region other than the gland duct region. False detection rejection means 7 compares the detection density of poorly differentiated cancer in the vicinity of a detection point with a threshold that is predetermined depending on gland duct density in the vicinity of the detection point, at each detection point detected by poorly differentiated cancer detection means 4 and rejects the detection point as a false detection if the detection density of a poorly differentiated cancer is smaller than the threshold.

    摘要翻译： 通过限制假检测可以提高腺癌分化不良的癌症的检测准确性。 细胞核检测装置1接收数字化的病理图像作为输入，并从中提取细胞核的区域。 腺体管检测装置2检测图像中的腺体管结构。 分化不良的癌症检测手段4仅在腺体管区域以外的区域检测分化不良的癌症。 假检测抑制装置7将检测点附近的分化不良的癌症的检测密度与根据检测点附近的腺体密度预先确定的阈值，在低分辨率癌症检测手段检测的各检测点进行比较 4，如果分化不良的癌症的检测密度小于阈值，则将检测点拒绝为假检测。

    Evaluation system, evaluation method, and recording medium
    7.
    发明授权
    Evaluation system, evaluation method, and recording medium 有权
    评价体系，评价方法和记录介质

    公开(公告)号：US08111897B2

    公开(公告)日：2012-02-07

    申请号：US12265394

    申请日：2008-11-05

    申请人： Yoshiko Yamashita ,  Kenji Okajima ,  Akira Saito

    发明人： Yoshiko Yamashita ,  Kenji Okajima ,  Akira Saito

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127 ,  G06T7/0012 ,  G06T2207/30024

    摘要： An evaluation system includes a capture unit for capturing an image of a living tissue in which HER2 protein and cell nucleuses are dyed, a discrimination unit for identifying a cell membrane from the image of the living tissue based on dyed cell nucleuses within the image of the living tissue captured by the capture unit to discriminate a dyed state of the cell membrane, and an evaluation unit for evaluating development of the HER2 protein based on a discrimination result by the discrimination unit.

    摘要翻译： 评价系统包括：捕获单元，用于捕获其中染色了HER2蛋白和细胞核的活组织的图像;鉴别单元，用于基于所述图像内的染色细胞核从所述活组织的图像识别细胞膜; 由捕获单元捕获的活体组织以鉴别细胞膜的染色状态，以及评估单元，用于基于鉴别单元的鉴别结果来评估HER2蛋白质的发育。

    EVALUATION SYSTEM, EVALUATION METHOD, AND RECORDING MEDIUM
    8.
    发明申请
    EVALUATION SYSTEM, EVALUATION METHOD, AND RECORDING MEDIUM 有权
    评估系统，评估方法和记录介质

    公开(公告)号：US20090116724A1

    公开(公告)日：2009-05-07

    申请号：US12265394

    申请日：2008-11-05

    申请人： Yoshiko Yamashita ,  Kenji Okajima ,  Akira Saito

    发明人： Yoshiko Yamashita ,  Kenji Okajima ,  Akira Saito

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00127 ,  G06T7/0012 ,  G06T2207/30024

    摘要： An evaluation system includes a capture unit for capturing an image of a living tissue in which HER2 protein and cell nucleuses are dyed, a discrimination unit for identifying a cell membrane from the image of the living tissue based on dyed cell nucleuses within the image of the living tissue captured by the capture unit to discriminate a dyed state of the cell membrane, and an evaluation unit for evaluating development of the HER2 protein based on a discrimination result by the discrimination unit.

    摘要翻译： 评价系统包括：捕获单元，用于捕获其中染色了HER2蛋白和细胞核的活组织的图像;鉴别单元，用于基于所述图像内的染色细胞核从所述活组织的图像识别细胞膜; 由捕获单元捕获的活体组织以鉴别细胞膜的染色状态，以及评估单元，用于基于鉴别单元的鉴别结果来评估HER2蛋白质的发育。

    Medicament for Improving Prognostic Survival in Therapy of Malignant Tumor
    10.
    发明申请
    Medicament for Improving Prognostic Survival in Therapy of Malignant Tumor 审中-公开
    改善恶性肿瘤治疗预后生存的药物

    公开(公告)号：US20080182791A1

    公开(公告)日：2008-07-31

    申请号：US12035936

    申请日：2008-02-22

    申请人： Kenji Okajima ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

    发明人： Kenji Okajima ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

    IPC分类号： A61K38/16 ,  A61P35/00

    CPC分类号： A61K38/4866

    摘要： A medicament for improving prognostic survival in therapy of malignant tumor is provided that may improve prognostic survival in DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. The medicament according to the invention comprises as a main active ingredient Activated Protein C, which is obtained from plasma or prepared by using the genetic recombination technique, and efficiently prolongs life-span of DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. In particular, the medicament may reduce adverse side effects of chemotherapeutics in chemotherapy of malignant tumor to enhance efficacy of said therapy and improve prognostic survival of patients suffering from malignant tumor.

    摘要翻译： 提供了一种用于改善恶性肿瘤治疗预后生存的药物，可以改善基底疾病是恶性肿瘤，特别是造血器官恶性肿瘤的DIC患者的预后生存。 根据本发明的药物包含作为主要活性成分的由血浆获得或通过使用遗传重组技术制备的活化蛋白C，并有效延长了基础疾病是恶性肿瘤，特别是恶性肿瘤的DIC患者的寿命 在造血器官。 特别地，药物可以减少化学治疗剂在恶性肿瘤化疗中的不良副作用，以增强所述治疗的疗效并改善恶性肿瘤患者的预后。