公开(公告)号：US5021419A

公开(公告)日：1991-06-04

申请号：US518252

申请日：1990-05-07

申请人： Yoshimasa Nakano ,  Michiharu Sugawara ,  Setsuyoshi Uetsuki ,  Taketoshi Izawa ,  Tomoyuki Kawaguchi ,  Akira Wada

发明人： Yoshimasa Nakano ,  Michiharu Sugawara ,  Setsuyoshi Uetsuki ,  Taketoshi Izawa ,  Tomoyuki Kawaguchi ,  Akira Wada

IPC分类号： A61K31/495 ,  A61P1/16 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P37/06 ,  A61P43/00 ,  C07D403/06 ,  C12P17/16 ,  C12R1/645

CPC分类号： C07D403/06 ,  C12P17/165 ,  Y10S514/825

摘要： A novel pyrazinoxide compound of NF-1616-904 having the formula (1), ##STR1## prepared by hydrolyzing the intermediate compound of NF-1616-902 which is separated from a culture broth of a microorganism belonging to the genus Thielavia.The pyazinoxide compound of NF-1616-904 possess biological and pharmacological activities, and is useful agent for preventing and treating diseases caused by superoxide radicals (O.sub.2.sup.-), and nephritis.

公开(公告)号：US5348858A

公开(公告)日：1994-09-20

申请号：US815875

申请日：1992-01-06

申请人： Setsuyoshi Uetsuki ,  Osamu Sato ,  Yasuo Nakayama ,  Yoshikatsu Hirai

发明人： Setsuyoshi Uetsuki ,  Osamu Sato ,  Yasuo Nakayama ,  Yoshikatsu Hirai

IPC分类号： C07K14/545 ,  C07K16/24 ,  C12N5/20 ,  C12N15/06 ,  C12P21/08 ,  G01N33/68 ,  G01N33/53 ,  C07K15/28

CPC分类号： G01N33/6869 ,  C07K14/545 ,  C07K16/245

摘要： The present invention provides a monoclonal antibody characterized in that the antibody has specific reactivity on human IL-1.beta., and a process for producing the antibody. The invention also provides a method for detection of biologically active human IL-1.beta..

摘要翻译： 本发明提供了一种单克隆抗体，其特征在于该抗体对人IL-1β具有特异性反应性，以及该抗体的制备方法。 本发明还提供了用于检测生物活性的人IL-1β的方法。