公开(公告)号：US5631350A

公开(公告)日：1997-05-20

申请号：US630918

申请日：1996-04-05

申请人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

发明人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/11 ,  C07K16/10 ,  C07K16/08 ,  C07K16/00

CPC分类号： C07K14/005 ,  C07K16/1018 ,  A61K38/00 ,  A61K39/00 ,  C12N2760/16122 ,  C12N2760/16222

摘要： An anti-human influenza virus antibody is provided having the following characteristics: (a) specifically binds to the stem region of hemagglutinin of human influenza A virus subtype H3N2; (b) does not specifically bind to the stem region of hemagglutinin of human influenza A virus subtypes H1N1 and H2N2; and (c) does not specifically bind to the stem region of hemagglutinin of human influenza B virus. A composition comprising the antibody is also provided.

摘要翻译： 提供具有以下特征的抗人流感病毒抗体：（a）特异性结合人甲型流感病毒亚型H3N2的血凝素的茎区; （b）不特异性结合人甲型流感病毒亚型H1N1和H2N2的血凝素的茎区; 和（c）不特异性结合人类乙型流感病毒血凝素的茎区。 还提供了包含该抗体的组合物。

公开(公告)号：US06720409B2

公开(公告)日：2004-04-13

申请号：US09918568

申请日：2001-08-01

申请人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

发明人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

IPC分类号： C07H2102

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/1018 ,  C12N2760/16122

摘要： [Object] To provide an anti-human influenza virus antibody and an immunogenic artificial polypeptide. [Constitution] An anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. An immunogenic artificial polypeptide having an antigenicity substantially same as the stem regions of haemagglutinin molecules. An immunogenic artificial polypeptide having an antigenicity substantially same as the stem regions of haemagglutinin molecule and lacking the globular head region of haemagglutinin molecules. [Effect] This antibody is useful in the diagnosis and treatment of influenza A virus, while these polypeptides are useful as a vaccine.

摘要翻译： 提供抗人流感病毒抗体和免疫原性人工多肽。[构成]一种抗人流感病毒抗体，其识别H1N1和H2N2亚型的血细胞凝集素分子的茎区，并具有中和活性，但不 识别H3N2亚型的干细胞区域，没有中和活性。 具有与血细胞凝集素分子的茎区域基本相同的抗原性的免疫原性人工多肽。 具有与血细胞凝集素分子的茎区域基本相同的抗原性的免疫原性人工多肽，并且缺乏血细胞凝集素分子的球形头部区域。[作用]该抗体可用于甲型流感病毒的诊断和治疗，而这些多肽可用作 疫苗。

公开(公告)号：US06337070B1

公开(公告)日：2002-01-08

申请号：US09004422

申请日：1998-01-08

申请人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

发明人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K16/1018 ,  C12N2760/16122

摘要： The invention provides an anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also provided is an immunogenic artificial polypeptide having an antigenicity substantially same as the stem region of haemagglutinin molecules, particularly lacking the globular head region of haemagglutinin molecules. This antibody is useful in the diagnosis and treatment of influenza A virus, while the polypeptides are useful as a vaccine.

摘要翻译： 本发明提供一种抗人流感病毒抗体，其识别H1N1和H2N2亚型的血细胞凝集素分子的茎区，并具有中和活性，但不识别H3N2亚型的茎区并且没有中和活性。 还提供了具有与血细胞凝集素分子的茎区域基本上相同的抗原性的免疫原性人造多肽，特别是缺乏血细胞凝集素分子的球形头部区域。该抗体可用于甲型流感病毒的诊断和治疗，而多肽可用作 一种疫苗

公开(公告)号：US5589174A

公开(公告)日：1996-12-31

申请号：US229781

申请日：1994-04-19

申请人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

发明人： Yoshinobu Okuno ,  Yuji Isegawa ,  Fuyoko Sasao ,  Shigeharu Ueda

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/11 ,  C07K16/10 ,  A61K39/395 ,  C07K16/08 ,  C12N5/20 ,  C12N15/06

CPC分类号： C07K14/005 ,  C07K16/1018 ,  A61K38/00 ,  A61K39/00 ,  C12N2760/16122 ,  C12N2760/16222

摘要： An anti-human influenza virus antibody is provided which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity, but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also provided is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecules. Provided further is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecule and lacking the globular head region of haemagglutinin molecules. The antibody is useful in the diagnosis and treatment of influenza A virus, while the polypeptides are useful as a vaccine.

摘要翻译： 提供抗人流感病毒抗体，其识别H1N1和H2N2亚型的血细胞凝集素分子的茎区，并具有中和活性，但不识别H3N2亚型的茎区并且没有中和活性。 还提供了具有与血细胞凝集素分子的茎区域基本相同的抗原性的免疫原性人造多肽。 还提供了具有与血细胞凝集素分子的茎区域基本相同的抗原性并且缺少血细胞凝集素分子的球形头部区域的免疫原性人造多肽。 该抗体可用于甲型流感病毒的诊断和治疗，而多肽可用作疫苗。