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公开(公告)号：US20130022665A1
公开(公告)日：2013-01-24
申请号：US13492650
申请日：2012-06-08
申请人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： A61K31/225 , A61K9/127 , A61K31/7052 , C07C69/34
CPC分类号： C07C237/08 , A61K9/0019 , A61K9/10 , A61K9/1271 , A61K31/713 , A61K47/186 , A61K47/543 , C07C323/60 , C07C333/04 , C12N15/113
摘要： Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of —CH2—, —S—, and —O— or absent; wherein Y is selected from —(CH2)n—S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester, wherein n=1-4; wherein a=1-4; wherein b=1-4; wherein c=1-4; and wherein Z is a counterion; as well as compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents; and methods of using these compositions and formulations.
摘要翻译： 这里描述的是式I化合物：其中R 1和R 2独立地选自C 10至C 18烷基，C 12至C 18烯基和油基; 其中R3和R4独立地选自C1-C6烷基和C2-C6链烷醇; 其中X选自-CH 2 - ， - S-和-O-或不存在; 其中Y选自 - （CH 2）n -S（CH 2）n，-O（CH 2）n - ，噻吩，-SO 2（CH 2）n - 和酯，其中n = 1-4; 其中a = 1-4; 其中b = 1-4; 其中c = 1-4; 并且其中Z是抗衡离子; 以及包含可用于递送治疗剂的式I化合物的组合物和药物制剂; 以及使用这些组合物和制剂的方法。
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公开(公告)号：US09011903B2
公开(公告)日：2015-04-21
申请号：US13492650
申请日：2012-06-08
申请人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： A61K31/225 , C07C69/34 , A61K9/127 , A61K31/7052 , A61K47/18 , A61K9/00 , A61K9/10 , A61K31/713 , C12N15/113
CPC分类号： C07C237/08 , A61K9/0019 , A61K9/10 , A61K9/1271 , A61K31/713 , A61K47/186 , A61K47/543 , C07C323/60 , C07C333/04 , C12N15/113
摘要： Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of —CH2—, —S—, and —O— or absent; wherein Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester, wherein n=1-4; wherein a=1-4; wherein b=1-4; wherein c=1-4; and wherein Z is a counterion; as well as compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents; and methods of using these compositions and formulations.
摘要翻译： 这里描述的是式I化合物：其中R 1和R 2独立地选自C 10至C 18烷基，C 12至C 18烯基和油基; 其中R3和R4独立地选自C1-C6烷基和C2-C6链烷醇; 其中X选自-CH 2 - ， - S-和-O-或不存在; 其中Y选自 - （CH 2）n，-S（CH 2）n，-O（CH 2）n - ，噻吩，-SO 2（CH 2）n - 和酯，其中n = 1-4; 其中a = 1-4; 其中b = 1-4; 其中c = 1-4; 并且其中Z是抗衡离子; 以及包含可用于递送治疗剂的式I化合物的组合物和药物制剂; 以及使用这些组合物和制剂的方法。
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公开(公告)号：US08753604B2
公开(公告)日：2014-06-17
申请号：US12646168
申请日：2009-12-23
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K47/62 , A61K47/6907 , A61K47/6923 , A61K49/0043 , A61K49/0082 , A61K49/0093 , A61K49/1866 , B82Y5/00
摘要： Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells and tumors.
摘要翻译： 公开了用于将治疗剂靶向癌细胞和肿瘤的组合物和方法。 所公开的靶向对于将治疗和可检测的药物递送至癌细胞和肿瘤是有用的。
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公开(公告)号：US20100172835A1
公开(公告)日：2010-07-08
申请号：US12646168
申请日：2009-12-23
CPC分类号： A61K45/06 , A61K47/62 , A61K47/6907 , A61K47/6923 , A61K49/0043 , A61K49/0082 , A61K49/0093 , A61K49/1866 , B82Y5/00
摘要： Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells and tumors.
摘要翻译： 公开了用于将治疗剂靶向癌细胞和肿瘤的组合物和方法。 所公开的靶向对于将治疗和可检测的药物递送至癌细胞和肿瘤是有用的。
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