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公开(公告)号：US08753604B2
公开(公告)日：2014-06-17
申请号：US12646168
申请日：2009-12-23
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K47/62 , A61K47/6907 , A61K47/6923 , A61K49/0043 , A61K49/0082 , A61K49/0093 , A61K49/1866 , B82Y5/00
摘要： Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells and tumors.
摘要翻译： 公开了用于将治疗剂靶向癌细胞和肿瘤的组合物和方法。 所公开的靶向对于将治疗和可检测的药物递送至癌细胞和肿瘤是有用的。
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公开(公告)号：US20100172835A1
公开(公告)日：2010-07-08
申请号：US12646168
申请日：2009-12-23
CPC分类号： A61K45/06 , A61K47/62 , A61K47/6907 , A61K47/6923 , A61K49/0043 , A61K49/0082 , A61K49/0093 , A61K49/1866 , B82Y5/00
摘要： Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells and tumors.
摘要翻译： 公开了用于将治疗剂靶向癌细胞和肿瘤的组合物和方法。 所公开的靶向对于将治疗和可检测的药物递送至癌细胞和肿瘤是有用的。
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公开(公告)号：US20110262347A1
公开(公告)日：2011-10-27
申请号：US13083176
申请日：2011-04-08
申请人： Erkki Ruoslahti , Lilach Agemy , Dinorah Friedmann-Morviniski , Venkata Ramana Kotamraju , Kazuki Sugahara , Inder Verma
发明人： Erkki Ruoslahti , Lilach Agemy , Dinorah Friedmann-Morviniski , Venkata Ramana Kotamraju , Kazuki Sugahara , Inder Verma
IPC分类号： A61K51/00 , C07K7/08 , C07K14/76 , A61K47/42 , A61K9/127 , C07F13/00 , C07H21/00 , A61K38/16 , A61K31/7088 , A61K31/28 , C07D305/14 , A61K31/337 , A61K49/00 , A61P35/00 , A61P43/00 , C07K7/06 , B82Y5/00
CPC分类号： A61K38/04 , A61K47/55 , A61K47/66 , A61K47/6923 , B82Y5/00
摘要： Disclosed are compositions and methods related to multivalent compositions targeted to cells and tissues. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
摘要翻译： 公开了与针对细胞和组织的多价组合物相关的组合物和方法。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。
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公开(公告)号：US20110165064A1
公开(公告)日：2011-07-07
申请号：US12973459
申请日：2010-12-20
IPC分类号： A61K51/00 , A61K49/00 , A61P7/02 , A61K33/26 , A61K38/36 , A61P17/02 , A61P31/00 , A61P35/00 , A61K9/127 , B82Y5/00
CPC分类号： A61K9/1272 , A61K9/1641 , A61K38/06 , A61K38/08 , A61K45/06
摘要： Disclosed are compositions and methods related to clot-binding compounds. For example, disclosed are compositions comprising a surface molecule and at least one modified clot-binding compound. The modified clot-binding compound can selectively bind to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors. The modified clot-binding compound can enhance the clotting in tumors compared to its unmodified derivative. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
摘要翻译： 公开了与凝块结合化合物相关的组合物和方法。 例如，公开了包含表面分子和至少一种经修饰的凝结结合化合物的组合物。 经修饰的凝块结合化合物可以选择性地结合凝血的血浆蛋白，其中所述组合物引起凝血并放大组合物在肿瘤中的积累。 与其未修饰的衍生物相比，经修饰的凝结结合化合物可以增强肿瘤中的凝血。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。
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公开(公告)号：US08912136B2
公开(公告)日：2014-12-16
申请号：US12973459
申请日：2010-12-20
IPC分类号： A61K38/00 , C07K14/755 , C07K7/06 , A61K45/06 , A61K38/06 , A61K9/127 , A61K38/08 , A61K9/16
CPC分类号： A61K9/1272 , A61K9/1641 , A61K38/06 , A61K38/08 , A61K45/06
摘要： Disclosed are compositions and methods related to clot-binding compounds. For example, disclosed are compositions comprising a surface molecule and at least one modified clot-binding compound. The modified clot-binding compound can selectively bind to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors. The modified clot-binding compound can enhance the clotting in tumors compared to its unmodified derivative. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
摘要翻译： 公开了与凝块结合化合物相关的组合物和方法。 例如，公开了包含表面分子和至少一种经修饰的凝结结合化合物的组合物。 经修饰的凝块结合化合物可以选择性地结合凝血的血浆蛋白，其中所述组合物引起凝血并放大组合物在肿瘤中的积累。 与其未修饰的衍生物相比，经修饰的凝结结合化合物可以增强肿瘤中的凝血。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。
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