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公开(公告)号：US09273128B2
公开(公告)日：2016-03-01
申请号：US14236793
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段 和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。
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公开(公告)号：US09180188B2
公开(公告)日：2015-11-10
申请号：US14236795
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译： 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。
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公开(公告)号：US09175074B2
公开(公告)日：2015-11-03
申请号：US14236859
申请日：2012-08-03
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
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公开(公告)号：US20140154261A1
公开(公告)日：2014-06-05
申请号：US14236859
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
摘要翻译： 本发明的目的是制备靶向癌细胞表面特异性表达的CAPRIN-1的抗体，对常规抗体具有优异的抗肿瘤活性，并提供抗体作为癌症治疗和/或预防剂的用途 。 本发明提供了靶向癌细胞表面特异表达的鉴定癌抗原蛋白的抗体作为癌症的治疗和/或预防剂的用途，特别是用于治疗和/或预防癌症的药物组合物，其包括作为 活性成分是与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体或其片段包含包含SEQ ID NO：5,6和7所代表的氨基酸序列的重链可变区和轻链 链可变区，其包含由SEQ ID NO：9,10和11表示的氨基酸序列。
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5.发明授权Pharmaceutical composition for treatment and/or prevention of pancreatic cancer 有权用于治疗和/或预防胰腺癌的药物组合物公开(公告)号：US09409993B2
公开(公告)日：2016-08-09
申请号：US14236818
申请日：2012-08-03
IPC分类号： A61K39/395 , C07K16/30 , C07K14/47 , C07K16/28 , A61K39/00
CPC分类号： C07K16/303 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/5258 , C07K14/4738 , C07K16/28 , C07K16/30 , C07K2317/10 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732
摘要： This invention relates to a pharmaceutical composition for treatment and/or prevention of pancreatic cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 to 12 or more consecutive amino acid residues.
摘要翻译： 本发明涉及一种用于治疗和/或预防胰腺癌的药物组合物，其包含与CAPRIN-1蛋白或其片段具有免疫反应性的抗体或其片段作为活性成分，其包含7至12个或更多个连续氨基 酸残留。
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公开(公告)号：US20140193434A1
公开(公告)日：2014-07-10
申请号：US14236795
申请日：2012-08-03
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译： 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。
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7.发明申请PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF PANCREATIC CANCER 有权用于治疗和/或预防胰腺癌的药物组合物公开(公告)号：US20140308283A1
公开(公告)日：2014-10-16
申请号：US14236818
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/303 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/5258 , C07K14/4738 , C07K16/28 , C07K16/30 , C07K2317/10 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732
摘要： This invention relates to a pharmaceutical composition for treatment and/or prevention of pancreatic cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 to 12 or more consecutive amino acid residues.
摘要翻译： 本发明涉及一种用于治疗和/或预防胰腺癌的药物组合物，其包含与CAPRIN-1蛋白或其片段具有免疫反应性的抗体或其片段作为活性成分，其包含7至12个或更多个连续氨基 酸残留。
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公开(公告)号：US20140186359A1
公开(公告)日：2014-07-03
申请号：US14236793
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段 和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。
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公开(公告)号：US20140178373A1
公开(公告)日：2014-06-26
申请号：US14236665
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6865 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
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公开(公告)号：US20110256144A1
公开(公告)日：2011-10-20
申请号：US13057709
申请日：2009-08-05
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/18
CPC分类号： C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分 酸。
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