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    Pharmaceutical composition for treatment and/or prophylaxis of cancer
    2.
    发明授权
    Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
    用于治疗和/或预防癌症的药物组合物

    公开(公告)号：US09180188B2

    公开(公告)日：2015-11-10

    申请号：US14236795

    申请日：2012-08-03

    申请人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

    发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

    IPC分类号： C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  A61K39/00

    CPC分类号： A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/732 ,  A61K2300/00

    摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

    摘要翻译： 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

    Non-aqueous electrolyte secondary battery
    4.
    发明授权
    Non-aqueous electrolyte secondary battery 有权
    非水电解质二次电池

    公开(公告)号：US07682749B2

    公开(公告)日：2010-03-23

    申请号：US12004019

    申请日：2007-12-20

    申请人： Shin-ichiro Sakaguchi ,  Yoshitaka Minamida ,  Satoru Naruse

    发明人： Shin-ichiro Sakaguchi ,  Yoshitaka Minamida ,  Satoru Naruse

    IPC分类号： H01M4/58

    CPC分类号： H01M4/625 ,  H01M4/364 ,  H01M4/485 ,  H01M10/052 ,  H01M2010/4292

    摘要： A non-aqueous electrolyte secondary battery uses, as its positive electrode or negative electrode, an electrode containing an active material and a conductive agent, the active material being made of a mixture of a molybdenum dioxide and a lithium titanium oxide in a weight ratio (molybdenum dioxide: lithium titanium oxide) of from 90:10 to 50:50, and the conductive agent containing graphitized vapor grown carbon fiber and massive graphite. The massive graphite has an average particle size of 10 μm or greater.

    摘要翻译： 非水电解质二次电池使用含有活性物质和导电剂的电极作为其正极或负极，所述活性物质由二氧化钼和氧化钛锂的混合物构成，重量比（ 二氧化钼：二氧化钛锂）为90:10〜50:50，导电剂含石墨化气相生长碳纤维和块状石墨。 大块石墨的平均粒径为10μm以上。

    Non-aqueous electrolyte secondary battery in which a carbon material is added to a negative-electrode active material
    5.
    发明申请
    Non-aqueous electrolyte secondary battery in which a carbon material is added to a negative-electrode active material 审中-公开
    在负极活性物质中添加碳材料的非水电解质二次电池

    公开(公告)号：US20060222949A1

    公开(公告)日：2006-10-05

    申请号：US11391698

    申请日：2006-03-29

    申请人： Yoshitaka Minamida ,  Seiji Morita ,  Nobuhiro Nishiguchi ,  Naoki Terada

    发明人： Yoshitaka Minamida ,  Seiji Morita ,  Nobuhiro Nishiguchi ,  Naoki Terada

    IPC分类号： H01M4/48 ,  H01M4/58 ,  H01M4/62 ,  H01M2/08

    CPC分类号： H01M10/0525 ,  H01M4/133 ,  H01M4/485 ,  H01M4/525 ,  H01M4/625 ,  H01M10/0585

    摘要： Provided is a non-aqueous electrolyte secondary battery whose negative-electrode mixture contains a carbon material in addition to spinel-structure lithium titanium oxide (negative-electrode active material), and which realizes positive-electrode deterioration curbing and excellent battery performance. In the non-aqueous electrolyte secondary battery whose negative-electrode active material is mainly constituted by spinel-structure lithium titanium oxide, a carbon material that has a d002 spacing in a range of 0.335 nm to 0.340 nm, inclusive, and a bulk density smaller than 0.1 g/cm3 is added to the negative-electrode active material. Even when overcharged, the non-aqueous electrolyte secondary battery is restrained from undergoing excessive positive-electrode potential increase, and so is capable of largely restraining deterioration of the positive electrode.

    摘要翻译： 提供一种非水电解质二次电池，其负极混合物除了尖晶石结构的锂钛氧化物（负极活性物质）之外还含有碳材料，并且实现正极劣化控制和优异的电池性能。 在其负极活性物质主要由尖晶石型锂钛氧化物构成的非水电解质二次电池中，具有在距离为0.335nm〜0.340nm的范围内的d002间隔的碳材料，其体积密度较小 向负极活性物质中添加0.1g / cm 3以上。 即使过充电，也能够抑制非水电解质二次电池的正极电位上升过大，能够大幅度地抑制正极的劣化。

    PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER
    7.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER 有权
    用于治疗和/或预防癌症的药物组合物

    公开(公告)号：US20140193434A1

    公开(公告)日：2014-07-10

    申请号：US14236795

    申请日：2012-08-03

    申请人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

    发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/732 ,  A61K2300/00

    摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

    摘要翻译： 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

    LI-LA-TI-O COMPOSITE SOLID ELECTROLYTE MATERIAL CONTAINING SILICON AND SYNTHESIZING METHOD THEREOF
    8.
    发明申请
    LI-LA-TI-O COMPOSITE SOLID ELECTROLYTE MATERIAL CONTAINING SILICON AND SYNTHESIZING METHOD THEREOF 有权
    含有硅的LI-LA-TI-O复合固体电解质材料及其合成方法

    公开(公告)号：US20110059369A1

    公开(公告)日：2011-03-10

    申请号：US12991496

    申请日：2009-07-24

    申请人： Cewen Nan ,  Ao Mei ,  Yuchuan Feng ,  Lin Yuanhua ,  Yoshitaka Minamida ,  Shoji Yokoishi

    发明人： Cewen Nan ,  Ao Mei ,  Yuchuan Feng ,  Lin Yuanhua ,  Yoshitaka Minamida ,  Shoji Yokoishi

    IPC分类号： H01M6/18

    CPC分类号： H01M10/0525 ,  H01M10/056 ,  H01M10/0562 ,  H01M10/0567 ,  H01M2300/0088

    摘要： The invention relates to a lithium lanthanum titanate composite solid electrolyte material containing silicon in which amorphous Si or an amorphous Si compound exist in a grain boundary between crystal grains, and a method of producing the same, and belongs to a field of a lithium ion battery. According to the invention, the amorphous Si or the amorphous Si compound exist in the grain boundary between the crystal grains of the lithium lanthanum titanate. The amorphous Si or the amorphous Si compound are introduced into the grain boundary by employing a wet chemical method. In the wet chemical method, the inexpensive organosilicon compound is used as an additive, and the organosilicon compound is added into the lithium lanthanum titanate solid electrolyte material. Thus, it is possible to synthesize the lithium lanthanum titanate composite solid electrolyte material containing silicon by performing sintering when the ratio of mass of the Si or mass of the Si calculated based on mass of the Si compound to mass of the lithium lanthanum titanate is 0.27% to 1.35%. Grain boundary conductivity thereof is significantly improved, and therefore, total conductivity is improved. In addition, processes of the experimental method are simple and easily performed. Also, an experimental period is greatly reduced, a synthesis temperature is reduced, and energy consumption and production cost are reduced.

    摘要翻译： 本发明涉及一种含有硅的钛酸锂复合固体电解质材料及其制造方法，其中非晶硅或非晶硅化合物存在于晶粒之间的晶界，属于锂离子电池领域 。 根据本发明，在钛酸镧镧的晶粒之间的晶界中存在非晶Si或非晶Si化合物。 通过采用湿法化学方法将非晶Si或非晶Si化合物引入晶界。 在湿化学方法中，使用便宜的有机硅化合物作为添加剂，并将有机硅化合物加入钛酸锂镧固体电解质材料中。 因此，当以Si化合物的质量计算的Si的质量或Si质量与质量的钛酸锂的比例为0.27时，可以通过进行烧结来合成含有硅的钛酸锂复合固体电解质材料。 ％至1.35％。 晶界电导率显着提高，因此总导电率提高。 另外，实验方法的过程简单易行。 此外，实验时间大大降低，合成温度降低，能量消耗和生产成本降低。

    Non-aqueous electrolyte secondary battery
    9.
    发明申请
    Non-aqueous electrolyte secondary battery 有权
    非水电解质二次电池

    公开(公告)号：US20080187836A1

    公开(公告)日：2008-08-07

    申请号：US12004019

    申请日：2007-12-20

    申请人： Shin-ichiro Sakaguchi ,  Yoshitaka Minamida ,  Satoru Naruse

    发明人： Shin-ichiro Sakaguchi ,  Yoshitaka Minamida ,  Satoru Naruse

    IPC分类号： H01M10/26

    CPC分类号： H01M4/625 ,  H01M4/364 ,  H01M4/485 ,  H01M10/052 ,  H01M2010/4292

    摘要： A non-aqueous electrolyte secondary battery uses, as its positive electrode or negative electrode, an electrode containing an active material and a conductive agent, the active material being made of a mixture of a molybdenum dioxide and a lithium titanium oxide in a weight ratio (molybdenum dioxide:lithium titanium oxide) of from 90:10 to 50:50, and the conductive agent containing graphitized vapor grown carbon fiber and massive graphite. The massive graphite has an average particle size of 10 μm or greater.

    摘要翻译： 非水电解质二次电池使用含有活性物质和导电剂的电极作为其正极或负极，所述活性物质由二氧化钼和氧化钛锂的混合物构成，重量比（ 二氧化钼：二氧化钛锂）为90:10〜50:50，导电剂含石墨化气相生长碳纤维和块状石墨。 大块石墨的平均粒径为10μm以上。