公开(公告)号：US09273128B2

公开(公告)日：2016-03-01

申请号：US14236793

申请日：2012-08-03

Applicant: Fumiyoshi Okano ,  Shinichi Kobayashi ,  Yoshitaka Minamida ,  Takanori Saito

Inventor： Fumiyoshi Okano ,  Shinichi Kobayashi ,  Yoshitaka Minamida ,  Takanori Saito

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/18 ,  A61K45/06 ,  C07K16/28

CPC classification number: C07K16/18 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段 和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

公开(公告)号：US09180188B2

公开(公告)日：2015-11-10

申请号：US14236795

申请日：2012-08-03

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/732 ,  A61K2300/00

Abstract: It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

Abstract translation: 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

公开(公告)号：US08985387B2

公开(公告)日：2015-03-24

申请号：US13253729

申请日：2011-10-05

Applicant: Shinichi Kobayashi

Inventor： Shinichi Kobayashi

IPC: B65D83/08 ,  B65G59/00 ,  A45C11/18

CPC classification number: B65D83/0829 ,  A45C11/182

Abstract: In order to provide a card case in which cards can be automatically and promptly discharged one by one, the case has a case body capable of accommodating more than one cards inside, a card discharging plate mounted so as to proceed from and retreat into the case body via a card discharging opening provided on a side portion of the case body, with a card being placed on its upper surface, and an elastic piece for movably urging the card discharging plate in one direction.

Abstract translation: 为了提供卡片可以一个一个地自动且及时地排出的卡片盒，该壳体具有能够容纳多于一个卡片的盒体，安装在其上的卡片放出板，以便从壳体 通过设置在壳体的侧部上的卡片排出口，具有放置在其上表面上的卡片以及用于沿一个方向可移动地推动卡片排出板的弹性件。

公开(公告)号：US08896500B2

公开(公告)日：2014-11-25

申请号：US13353731

申请日：2012-01-19

Applicant: Shinichi Kobayashi

Inventor： Shinichi Kobayashi

IPC: G09G5/00 ,  G02B27/01 ,  G09G3/00 ,  G09G3/34

CPC classification number: G02B27/017 ,  G02B2027/014 ,  G02B2027/0178 ,  G09G3/003 ,  G09G3/3406 ,  G09G2310/0237

Abstract: A head-mounted display device that is mounted on the head of an observer and forms a virtual image before the eyes of the observer includes: a display device that forms an image, which is the source of image light, from image data; a light source that emits the image light representing the formed image; a light guide unit that forms a virtual image from the emitted image light; and a display control unit that turns off the light source and changes the head-mounted display device to a suspension mode when a suspension request is received from the outside.

Abstract translation: 安装在观察者的头部并在观察者的眼睛之前形成虚拟图像的头戴式显示装置包括：从图像数据形成作为图像光源的图像的显示装置; 发出表示形成图像的图像光的光源; 导光单元，其从所发射的图像光形成虚拟图像; 以及显示控制单元，当从外部接收到暂停请求时，关闭光源并将头戴式显示设备改变为暂停模式。

公开(公告)号：US20140178373A1

公开(公告)日：2014-06-26

申请号：US14236665

申请日：2012-08-03

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6861 ,  A61K47/6865 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/732

Abstract: An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

公开(公告)号：US08565845B2

公开(公告)日：2013-10-22

申请号：US12293143

申请日：2008-02-06

Applicant: Shinichi Kobayashi ,  Tetsuyuki Kaneko

Inventor： Shinichi Kobayashi ,  Tetsuyuki Kaneko

IPC: H01F6/06 ,  H01B12/02

CPC classification number: H01F6/06

Abstract: The invention offers a superconducting coil that has the shape of a pancake formed by winding a superconducting conductor. The superconducting conductor is composed of a tape-shaped (Bi, Pb)2223-based superconducting wire and a tape-shaped thin-film RE123-based superconducting wire that are electrically connected in parallel with each other. The coil generates only a low voltage in the steady-operation state, limits the generated voltage to a low level even in a state where an external disturbance enters for some reason, and is therefore less susceptible to quenching. Consequently, the coil can be operated stably in both states. The invention also offers a superconducting conductor to be used to form the coil.

Abstract translation: 本发明提供一种超导线圈，其具有通过缠绕超导导体形成的薄饼形状。 超导导体由彼此并联电连接的带状（Bi，Pb）2223基超导线和带状薄膜RE123基超导线构成。 线圈在稳定运行状态下仅产生低电压，即使在由于某种原因导致外部干扰进入的状态下也将发电电压限制在低电平，因此不易于淬火。 因此，能够以两种状态稳定地操作线圈。 本发明还提供一种用于形成线圈的超导导体。

公开(公告)号：US08184343B2

公开(公告)日：2012-05-22

申请号：US11014912

申请日：2004-12-20

Applicant: Erika Tani ,  Taketoshi Yamashita ,  Shigeki Washino ,  Shinichi Utsumi ,  Yoshiharu Hibi ,  Shinichi Kobayashi ,  Katsuhiko Sugawara ,  Koji Aikawa ,  Yu Tsuda ,  Kohei Genda ,  Yoshio Kanesawa ,  Masaru Okutsu

Inventor： Erika Tani ,  Taketoshi Yamashita ,  Shigeki Washino ,  Shinichi Utsumi ,  Yoshiharu Hibi ,  Shinichi Kobayashi ,  Katsuhiko Sugawara ,  Koji Aikawa ,  Yu Tsuda ,  Kohei Genda ,  Yoshio Kanesawa ,  Masaru Okutsu

IPC: H04N1/40 ,  G06F15/00

CPC classification number: G06T11/60 ,  G06F17/3028 ,  G06T1/0021 ,  G06T2201/0051

Abstract: There are provided a first section for acquiring image data; a second section for storing the acquired image data; a third section for acquiring accessory information; a fourth section for storing the accessory information; a fifth section for generating an image ID and an accessory information ID; a sixth section for embedding the image ID and the accessory information ID in the image data; a seventh section for extracting an image ID and an accessory information ID from a result of scanning of the index sheet; an eighth section for reading accessory information on the basis of the accessory information ID; a ninth section for selecting image data through use of accessory information; a tenth section for reading selected image data; an eleventh section for arranging the image data; and a twelfth section for sending index sheet images having the information embedded therein and the arranged album images.

Abstract translation: 提供了用于获取图像数据的第一部分; 第二部分，用于存储所获取的图像数据; 用于获取附件信息的第三部分; 用于存储附件信息的第四部分; 用于生成图像ID和附件信息ID的第五部分; 用于将图像ID和附件信息ID嵌入图像数据中的第六部分; 第七部分，用于从索引片的扫描结果中提取图像ID和附件信息ID; 第八部分，用于根据附件信息ID读取附件信息; 用于通过使用附件信息来选择图像数据的第九部分; 用于读取所选择的图像数据的第十部分; 用于布置图像数据的第十一部分; 以及第十二部分，用于发送具有嵌入信息的索引片图像和排列的相册图像。

公开(公告)号：US20110256144A1

公开(公告)日：2011-10-20

申请号：US13057709

申请日：2009-08-05

Applicant: Fumiyoshi Okano ,  Takayoshi Ido ,  Takanori Saito ,  Shinichi Kobayashi

Inventor： Fumiyoshi Okano ,  Takayoshi Ido ,  Takanori Saito ,  Shinichi Kobayashi

IPC: A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/18

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3053 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

Abstract translation: 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分 酸。

公开(公告)号：US20100290894A1

公开(公告)日：2010-11-18

申请号：US12719941

申请日：2010-03-09

Applicant: Motohiro TAKEMAE ,  Shinichi Kobayashi

Inventor： Motohiro TAKEMAE ,  Shinichi Kobayashi

IPC: F04D17/08 ,  F04D29/42

CPC classification number: F04D17/08 ,  F04D29/42

Abstract: A blower fan unit includes a housing, an impeller, an outlet, and a positioning mechanism. The impeller is mounted in the housing. The impeller rotates around a rotation center axis and generates an air current in a centrifugal direction from the rotation center axis. An outlet is formed in the housing and located in a centrifugal direction from the rotation center axis. A positioning mechanism is connected to the housing and makes the position of the housing change along the rotation center axis at each angular position around the rotation center axis.

Abstract translation: 鼓风机单元包括壳体，叶轮，出口和定位机构。 叶轮安装在外壳中。 叶轮围绕旋转中心轴线旋转，并从旋转中心轴线沿离心方向产生气流。 出口形成在壳体中并且位于离旋转中心轴线的离心方向。 定位机构连接到壳体，并且使得壳体的位置沿着旋转中心轴线在围绕旋转中心轴线的每个角位置处改变。

公开(公告)号：US20100236333A1

公开(公告)日：2010-09-23

申请号：US12708017

申请日：2010-02-18

Applicant: Masahiko ARAI ,  Shinichi KOBAYASHI ,  Hiroyuki DOI ,  Hiroaki CHIBA ,  Takashi HANEISHI

Inventor： Masahiko ARAI ,  Shinichi KOBAYASHI ,  Hiroyuki DOI ,  Hiroaki CHIBA ,  Takashi HANEISHI

IPC: G01N3/02

CPC classification number: G01N3/60 ,  G01N2203/0071 ,  G01N2203/0688 ,  G01N2203/0694

Abstract: The present invention is intended to provide a method for assessing remaining lifespan of a bolt with higher precision than conventional methods, which can be applied to a bolt comprising a high alloy with fewer tissue changes caused by creep damage.The present invention provides a method for assessing the remaining lifespan of a bolt used at high temperatures, including: carrying out a creep test for a bolt material that constitutes a bolt to be assessed and determining a life-time and a life-elongation rate; determining a time-temperature parameter based on the life-time and the creep test temperature; creating a lifespan-assessment diagram by plotting the time-temperature parameter with respect to the life-elongation rate; measuring a elongation rate between before and after the use of the bolt to be assessed; and assessing the remaining lifespan of the bolt with the use of the elongation rate between before and after the use of the bolt to be assessed and the lifespan-assessment diagram.

Abstract translation: 本发明旨在提供一种用于评估具有比常规方法更高精度的螺栓的剩余寿命的方法，其可以应用于包括由蠕变损伤引起的较少组织变化的高合金的螺栓。 本发明提供一种用于评估在高温下使用的螺栓的剩余寿命的方法，包括：对构成要评估的螺栓的螺栓材料进行蠕变试验，并确定寿命和寿命延长率; 根据寿命和蠕变试验温度确定时间 - 温度参数; 通过绘制时间 - 温度参数相对于寿命延长率来创建寿命评估图; 测量在使用要评估的螺栓之前和之后的伸长率; 并使用在评估螺栓的使用前后的伸长率和寿命评估图来评估螺栓的剩余寿命。