公开(公告)号：US20110213408A1

公开(公告)日：2011-09-01

申请号：US12602787

申请日：2009-09-29

申请人： Yossi Gross ,  Itzik Avneri ,  Omry Ben Ezra ,  Ori Weisberg ,  Raanan Gefen

发明人： Yossi Gross ,  Itzik Avneri ,  Omry Ben Ezra ,  Ori Weisberg ,  Raanan Gefen

IPC分类号： A61B17/00

CPC分类号： A61B5/021 ,  A61B5/022 ,  A61B5/6862 ,  A61B5/6876

摘要： Apparatus is provided for reducing hypertension of a subject. A selective circumferential pressure applicator (60) includes at least two surfaces (61) that increase baroreceptor activity of the subject, by applying pressure to an artery (20) of the subject at two or more respective non-contiguous regions around the circumference of the artery, at a longitudinal site of the artery, such that between the non-contiguous regions, at the longitudinal site (a) there is at least one region (22) of the artery that is more relaxed than in the absence of the device, and (b) there is at least one region (21) of the artery that is more tense than in the absence of the device. A joint (63) couples the surfaces to each other. For at least a portion of the subject's cardiac cycle, the joint does not to contact the subject's artery. Other applications are also provided.

摘要翻译： 提供用于减少受试者的高血压的装置。 选择性周向压力施加器（60）包括至少两个增加受试者压力感受器活性的表面（61），所述至少两个表面（61）通过在受试者的动脉（20）周围的两个或更多个相邻的非连续区域周围施加压力 动脉，在动脉的纵向位置处，使得在不连续区域之间，在纵向位置（a）处，与没有装置相比，动脉的至少一个区域（22）比较松弛， 和（b）动脉的至少一个区域（21）比不存在装置时更紧张。 接头（63）将表面彼此连接。 对于受试者心脏周期的至少一部分，关节不接触受试者的动脉。 还提供其他应用。

公开(公告)号：US09125567B2

公开(公告)日：2015-09-08

申请号：US12602787

申请日：2009-09-29

申请人： Yossi Gross ,  Itzik Avneri ,  Omry Ben Ezra ,  Ori Weisberg ,  Raanan Gefen

发明人： Yossi Gross ,  Itzik Avneri ,  Omry Ben Ezra ,  Ori Weisberg ,  Raanan Gefen

IPC分类号： A61B17/00 ,  A61B5/021 ,  A61B5/00 ,  A61B5/022

CPC分类号： A61B5/021 ,  A61B5/022 ,  A61B5/6862 ,  A61B5/6876

摘要： Apparatus is provided for reducing hypertension of a subject. A selective circumferential pressure applicator (60) includes at least two surfaces (61) that increase baroreceptor activity of the subject, by applying pressure to an artery (20) of the subject at two or more respective non-contiguous regions around the circumference of the artery, at a longitudinal site of the artery, such that between the non-contiguous regions, at the longitudinal site (a) there is at least one region (22) of the artery that is more relaxed than in the absence of the device, and (b) there is at least one region (21) of the artery that is more tense than in the absence of the device. A joint (63) couples the surfaces to each other. For at least a portion of the subject's cardiac cycle, the joint does not to contact the subject's artery. Other applications are also provided.

摘要翻译： 提供用于减少受试者的高血压的装置。 选择性周向压力施加器（60）包括至少两个增加受试者压力感受器活性的表面（61），所述至少两个表面（61）通过在受试者的动脉（20）周围的两个或更多个相邻的非连续区域周围施加压力 动脉，在动脉的纵向位置处，使得在不连续区域之间，在纵向位置（a）处，与没有装置相比，动脉的至少一个区域（22）比较松弛， 和（b）动脉的至少一个区域（21）比不存在装置时更紧张。 接头（63）将表面彼此连接。 对于受试者心脏周期的至少一部分，关节不接触受试者的动脉。 还提供其他应用。

公开(公告)号：US20050065553A1

公开(公告)日：2005-03-24

申请号：US10866601

申请日：2004-06-10

申请人： Omry Ben Ezra ,  Ehud Cohen ,  Tamir Ben David

发明人： Omry Ben Ezra ,  Ehud Cohen ,  Tamir Ben David

IPC分类号： A61N20060101 ,  A61N1/18 ,  A61N1/36 ,  A61N1/362 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.

摘要翻译： 提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。 该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎， 包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合 结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

公开(公告)号：US07561922B2

公开(公告)日：2009-07-14

申请号：US11022011

申请日：2004-12-22

申请人： Ehud Cohen ,  Tamir Ben David ,  Shai Ayal ,  Omry Ben Ezra

发明人： Ehud Cohen ,  Tamir Ben David ,  Shai Ayal ,  Omry Ben Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0556

摘要： Apparatus is provided for applying current to a nerve, including a housing that is adapted to be placed in a vicinity of the nerve. First, second, and third electrodes are fixed to the housing at first, second, and third longitudinal sites of the housing, respectively. The first, second, and third electrodes do not come in direct physical contact with the nerve. The second site is between the first and third sites. The second electrode has an electrode surface axial length. The apparatus also includes first and second internal insulating elements, which are fixed to the housing between the first and second longitudinal sites, and between the second and third longitudinal sites, respectively. The first and second internal insulating elements are shaped so as to define, upon placement of the housing, a nerve axial distance between the first and second internal insulating elements that is less than the electrode surface axial length.

摘要翻译： 提供了用于向神经施加电流的装置，包括适于放置在神经附近的壳体。 第一，第二和第三电极分别在壳体的第一，第二和第三纵向位置处固定到壳体。 第一，第二和第三电极不会与神经直接物理接触。 第二个站点在第一个和第三个站点之间。 第二电极具有电极表面的轴向长度。 该装置还包括第一和第二内部绝缘元件，其分别在第一和第二纵向位置之间以及第二和第三纵向位置之间固定到壳体。 第一和第二内部绝缘元件被成形为在放置壳体时限定第一和第二内部绝缘元件之间的小于电极表面轴向长度的神经轴向距离。

公开(公告)号：US20090005845A1

公开(公告)日：2009-01-01

申请号：US12012366

申请日：2008-02-01

申请人： Tamir Ben David ,  Omry Ben Ezra ,  Ehud Cohen

发明人： Tamir Ben David ,  Omry Ben Ezra ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/0558 ,  A61N1/0573 ,  A61N1/36114

摘要： A method is provided, including implanting in an atrial wall of a subject, from within an atrium, a first electrode contact in a vicinity of a parasympathetic epicardial fat pad of the subject, and implanting a second electrode contact in a body of the subject outside of a heart and a circulatory system. A current is driven between the first and second electrode contacts, and configured to cause parasympathetic activation of the fat pad. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括从心房内植入在受试者的心房壁中，在受试者的副交感神经心外膜脂肪垫附近的第一电极接触，以及将第二电极接触植入对象的身体外部 的心脏和循环系统。 电流在第一和第二电极触点之间被驱动，并且被配置为引起脂肪垫的副交感神经激活。 还描述了其它实施例。

公开(公告)号：US07321793B2

公开(公告)日：2008-01-22

申请号：US10461696

申请日：2003-06-13

申请人： Omry Ben Ezra ,  Ehud Cohen ,  Tamir Ben David

发明人： Omry Ben Ezra ,  Ehud Cohen ,  Tamir Ben David

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： Apparatus for treating a subject suffering from spontaneous atrial fibrillation includes an electrode device, adapted to be coupled to a vagus nerve of the subject, and a control unit, adapted to drive the electrode device to apply an electrical current to the vagus nerve, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.

摘要翻译： 用于治疗患有自发性心房颤动的受试者的装置包括适于耦合到受试者的迷走神经的电极装置和适于驱动电极装置向迷走神经施加电流的控制单元，以及 配置电流以维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。