公开(公告)号：US4933329A

公开(公告)日：1990-06-12

申请号：US280402

申请日：1988-12-06

申请人： Youichiro Naito ,  Yasunari Yamaura ,  Masanori Sugiura ,  Chikara Fukaya ,  Kazumasa Yokoyama

发明人： Youichiro Naito ,  Yasunari Yamaura ,  Masanori Sugiura ,  Chikara Fukaya ,  Kazumasa Yokoyama

IPC分类号： A61K31/10 ,  A61K31/22 ,  A61K31/27 ,  A61K31/325 ,  A61K31/495 ,  A61K31/66 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P19/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C67/00 ,  C07C313/00 ,  C07C323/20 ,  C07D295/08 ,  C07D295/096 ,  C07F9/09 ,  C07F9/12

CPC分类号： C07D295/096 ,  A61K31/10 ,  C07C323/00 ,  C07C323/20 ,  C07F9/12 ,  Y10S514/826

摘要： Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various diseases, including allergic diseases such as asthma, inflammation, myocardial infarction, nephritis, scabies and gout.