公开(公告)号：US20130052134A1

公开(公告)日：2013-02-28

申请号：US13518874

申请日：2010-12-28

申请人： Yourong Duan ,  Peifeng Liu ,  Ying Sun ,  Ming Shen ,  Mingjie Zhu ,  Yanming Sun ,  Qi Wang ,  Zelai He ,  Liubin Qin ,  Hui Yu ,  Xiaoyu Li ,  Xuelian Qi ,  Xiaoyan Chen ,  Qiufen Sun ,  Bingwu Wang

发明人： Yourong Duan ,  Peifeng Liu ,  Ying Sun ,  Ming Shen ,  Mingjie Zhu ,  Yanming Sun ,  Qi Wang ,  Zelai He ,  Liubin Qin ,  Hui Yu ,  Xiaoyu Li ,  Xuelian Qi ,  Xiaoyan Chen ,  Qiufen Sun ,  Bingwu Wang

IPC分类号： A61K47/34 ,  A61K49/00 ,  C08G63/91 ,  A61K9/14 ,  B82Y5/00

CPC分类号： A61K48/0041 ,  A61K9/5153 ,  A61K47/62 ,  A61K47/6935 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/912 ,  C08G69/10 ,  C08G69/44 ,  C08G2261/126 ,  C12N15/87

摘要： This invention belongs to the nanotechnology field, and discloses a nano drug delivery system with polyethyleneglycol-poly(lactic-co-glycolic acid)-poly-L-lysine (PEG-PLGA-PLL) polymer as the skeleton. The carrier can have the function of passive targeting through control of the carrier particle size. The polymer skeleton is modified through introducing side chains and specific targeting groups, so as to adjust and improve the carrier performance, and enable the carrier to have the function of active targeting. Such carrier material also has the functions of transporting active substances, tumor treatment and diagnosis, ultrasonic contrast, reversing or reducing drug resistance and so on. It is mainly applied to (1) Targeting preparation of anticancer drugs; (2) preparation to reverse or reduce the drug resistance of the tumor; (3) reagent for tumor diagnosis and contrast; (4) reagent to transfect DNA plasmids; (5) pharmaceutical preparation for cancer gene therapy; (6) reagent used to transfect antisense nucleic acid and siRNA (RNA interference); (7) pharmaceutical preparation used to prepare antisense nucleic acid and siRNA (RNA interference).

摘要翻译： 本发明属于纳米技术领域，公开了以聚乙二醇 - 聚（乳酸 - 共 - 乙醇酸） - 聚-L-赖氨酸（PEG-PLGA-PLL）聚合物为骨架的纳米药物输送系统。 通过控制载体粒径，载体可以具有被动靶向的功能。 通过引入侧链和特异性靶向基来改进聚合物骨架，从而调节和改善载体性能，并使载体具有主动靶向功能。 这种载体材料还具有运输活性物质，肿瘤治疗和诊断，超声对比，逆转或降低耐药性等功能。 主要适用于（1）抗癌药物的靶向制备; （2）准备逆转或降低肿瘤的耐药性; （3）肿瘤诊断试剂和对比剂; （4）转染DNA质粒的试剂; （5）癌基因治疗药物制剂; （6）用于转染反义核酸和siRNA（RNA干扰）的试剂; （7）用于制备反义核酸和siRNA（RNA干扰）的药物制剂。