公开(公告)号：US20160102076A1

公开(公告)日：2016-04-14

申请号：US14881930

申请日：2015-10-13

申请人： Yuhan Corporation

发明人： Byung-Chul Suh ,  Paresh Devidas Salgaonkar ,  Jaekyoo Lee ,  Jong Sung Koh ,  Ho-Juhn Song ,  In Yong Lee ,  Jaesang Lee ,  Dong Sik Jung ,  Jung-Ho Kim ,  Se-Won Kim

IPC分类号： C07D403/04 ,  C07D409/14 ,  C07D413/14 ,  C07D403/14

CPC分类号： C07D403/04 ,  A61K31/506 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefore. The invention also provides useful intermediates generated during the syntheses of the aminopyrimidine derivatives.

摘要翻译： 本发明提供了一组可用于治疗细胞增殖性疾病和病症如癌症和免疫疾病的蛋白激酶抑制剂，氨基嘧啶衍生物及其药学上可接受的盐。 本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。 本发明还提供了包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂的药物制剂。 本发明还提供了在合成氨基嘧啶衍生物期间产生的有用的中间体。

公开(公告)号：US11945798B2

公开(公告)日：2024-04-02

申请号：US17822438

申请日：2022-08-26

申请人： YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

发明人： Hyunjoo Lee ,  Su Bin Choi ,  Young Ae Yoon ,  Kwan Hoon Hyun ,  Jae Young Sim ,  Marian C. Bryan ,  Scott Kuduk ,  James Campbell Robertson ,  Jaekyoo Lee ,  Paresh Devidas Salgaonkar ,  Byung-Chul Suh ,  Jong Sung Koh ,  So Young Hwang

IPC分类号： C07D401/14 ,  C07D413/14

CPC分类号： C07D401/14 ,  C07D413/14

摘要： Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US09593098B2

公开(公告)日：2017-03-14

申请号：US14881930

申请日：2015-10-13

申请人： Yuhan Corporation

发明人： Byung-Chul Suh ,  Paresh Devidas Salgaonkar ,  Jaekyoo Lee ,  Jong Sung Koh ,  Ho-Juhn Song ,  In Yong Lee ,  Jaesang Lee ,  Dong Sik Jung ,  Jung-Ho Kim ,  Se-Won Kim

IPC分类号： A61K31/506 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14

CPC分类号： C07D403/04 ,  A61K31/506 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefore. The invention also provides useful intermediates generated during the syntheses of the aminopyrimidine derivatives.

摘要翻译： 本发明提供了一组可用于治疗细胞增殖性疾病和病症如癌症和免疫疾病的蛋白激酶抑制剂，氨基嘧啶衍生物及其药学上可接受的盐。 本发明提供了合成和施用蛋白激酶抑制剂化合物的方法。 本发明还提供了包含至少一种蛋白激酶抑制剂化合物以及药学上可接受的载体，稀释剂或赋形剂的药物制剂。 本发明还提供了在合成氨基嘧啶衍生物期间产生的有用的中间体。