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公开(公告)号：US08586103B2
公开(公告)日：2013-11-19
申请号：US12366402
申请日：2009-02-05
申请人： Yuhua Li , Andrew Guarino , Benjamin Chien
发明人： Yuhua Li , Andrew Guarino , Benjamin Chien
IPC分类号： A01N65/00
CPC分类号： A61K38/31 , A61K9/0024 , A61K31/428 , A61K31/485 , A61K31/7036 , A61K31/704 , A61K38/09 , A61K38/26 , A61K47/541
摘要： The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
摘要翻译： 本发明提供了一种适用于原位形成贮库系统以便以受控方式递送生物活性物质的新型液体组合物。 本发明的组合物包括：（a）疏水性非聚合物载体材料; （b）溶解疏水性非聚合物材料的水混溶性生物相容性有机溶剂; （c）在两亲性分子和具有中性pH在水中的净电荷的生物活性物质之间形成的离子络合物。 本发明还提供了其组合物的制造和使用方法。
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公开(公告)号：US20090202481A1
公开(公告)日：2009-08-13
申请号：US12366321
申请日：2009-02-05
申请人： Yuhua Li , Andrew Guarino , Benjamin Chien
发明人： Yuhua Li , Andrew Guarino , Benjamin Chien
CPC分类号： A61K38/193 , A61K9/0024 , A61K38/26 , A61K38/28 , A61K38/31 , A61K38/47 , A61K47/542 , A61K47/543 , A61K47/60
摘要： The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a protein or peptide in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) a protein or peptide covalently conjugated with one or more formulation performance-enhancing compounds. The present invention also provides a method of manufacturing and use of the composition thereof.
摘要翻译： 本发明提供了一种新颖的液体组合物，其适用于原位形成以受控方式递送蛋白质或肽的贮库系统。 本发明的组合物包括：（a）疏水性非聚合物载体材料; （b）溶解疏水性非聚合物材料的水混溶性生物相容性有机溶剂; （c）与一种或多种配制性能增强化合物共价缀合的蛋白质或肽。 本发明还提供了其组合物的制造和使用方法。
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公开(公告)号：US20100034801A1
公开(公告)日：2010-02-11
申请号：US12366402
申请日：2009-02-05
申请人： Yuhua Li , Andrew Guarino , Benjamin Chien
发明人： Yuhua Li , Andrew Guarino , Benjamin Chien
IPC分类号： A61K38/12 , A61K38/08 , A61K31/704 , A61K31/426 , A61K31/7036 , A61K38/47 , A61K31/485 , A61P25/00
CPC分类号： A61K38/31 , A61K9/0024 , A61K31/428 , A61K31/485 , A61K31/7036 , A61K31/704 , A61K38/09 , A61K38/26 , A61K47/541
摘要： The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
摘要翻译： 本发明提供了一种适用于原位形成贮库系统以便以受控方式递送生物活性物质的新型液体组合物。 本发明的组合物包括：（a）疏水性非聚合物载体材料; （b）溶解疏水性非聚合物材料的水混溶性生物相容性有机溶剂; （c）在两亲性分子和具有中性pH在水中的净电荷的生物活性物质之间形成的离子络合物。 本发明还提供了其组合物的制造和使用方法。
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公开(公告)号：US20180050108A1
公开(公告)日：2018-02-22
申请号：US15661066
申请日：2017-07-27
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K9/0031 , A61K9/0034 , A61K9/0073 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/5031 , A61K38/09 , A61K38/2292 , A61K47/14 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
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公开(公告)号：US08206735B2
公开(公告)日：2012-06-26
申请号：US11827260
申请日：2007-07-11
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
IPC分类号： A61K47/48
CPC分类号： A61K38/1808 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K38/2278 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/47 , A61K47/542 , A61K47/543 , A61K47/60
摘要： The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
摘要翻译： 本发明提供了通过施用包含有效量的生物相容性，水不溶性，可生物降解的聚合物和有效量的与一种共价修饰的治疗肽的液体药物组合物在体内原位形成固体，可生物降解的植入物的方法 或更多亲脂性或两亲性部分，其被溶解或分散在生物相容的水溶性有机溶剂中。 本发明还提供相关的组合物和方法。
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公开(公告)号：US20070196416A1
公开(公告)日：2007-08-23
申请号：US11653636
申请日：2007-01-16
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K9/0031 , A61K9/0034 , A61K9/0073 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/146 , A61K9/5031 , A61K38/09 , A61K38/2292 , A61K47/14 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
摘要翻译： 本发明提供了可用作肽剂的控制释放递送系统的稳定的可生物降解的聚合物组合物。 本发明的组合物包含a）由强酸形成的肽剂的有益盐，其使有机溶液中肽剂和聚合物之间的相互作用/反应最小化或防止; b）可生物降解的聚合物; c）药学上可接受的有机溶剂; 和d）任选的一种或多种赋形剂。 本发明还涉及一种制造方法及其使用方法。
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公开(公告)号：US20170119842A1
公开(公告)日：2017-05-04
申请号：US15406321
申请日：2017-01-13
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K38/09 , A61K38/2292 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
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公开(公告)号：US09572857B2
公开(公告)日：2017-02-21
申请号：US15230413
申请日：2016-08-06
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K38/09 , A61K38/2292 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
摘要翻译： 本发明提供了可用作肽剂的控制释放递送系统的稳定的可生物降解的聚合物组合物。 本发明的组合物包含a）由强酸形成的肽剂的有益盐，其使有机溶液中肽剂和聚合物之间的相互作用/反应最小化或防止; b）可生物降解的聚合物; c）药学上可接受的有机溶剂; 和d）任选的一种或多种赋形剂。 本发明还涉及一种制造方法及其使用方法。
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公开(公告)号：US20160331802A1
公开(公告)日：2016-11-17
申请号：US15230413
申请日：2016-08-06
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0024 , A61K38/09 , A61K38/2292 , A61K47/22
摘要： The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
摘要翻译： 本发明提供了可用作肽剂的控制释放递送系统的稳定的可生物降解的聚合物组合物。 本发明的组合物包含a）由强酸形成的肽剂的有益盐，其使有机溶液中肽剂和聚合物之间的相互作用/反应最小化或防止; b）可生物降解的聚合物; c）药学上可接受的有机溶剂; 和d）任选的一种或多种赋形剂。 本发明还涉及一种制造方法及其使用方法。
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公开(公告)号：US08840915B2
公开(公告)日：2014-09-23
申请号：US13480544
申请日：2012-05-25
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
IPC分类号： A61K38/25 , A61K38/47 , A61K47/48 , A61K9/19 , A61K9/00 , A61K38/26 , A61K38/29 , A61K38/18 , A61K38/22
CPC分类号： A61K38/1808 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K38/2278 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/47 , A61K47/542 , A61K47/543 , A61K47/60
摘要： The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
摘要翻译： 本发明提供了通过施用包含有效量的生物相容性，水不溶性，可生物降解的聚合物和有效量的与一种共价修饰的治疗肽的液体药物组合物在体内原位形成固体，可生物降解的植入物的方法 或更多亲脂性或两亲性部分，其被溶解或分散在生物相容的水溶性有机溶剂中。 本发明还提供相关的组合物和方法。
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