公开(公告)号：US06186756B1

公开(公告)日：2001-02-13

申请号：US09572049

申请日：2000-05-16

申请人： Yukihiro Kojima ,  Tetsuya Sasage ,  Noboru Toda

发明人： Yukihiro Kojima ,  Tetsuya Sasage ,  Noboru Toda

IPC分类号： F04C200

CPC分类号： F04C29/0071 ,  F04C18/16 ,  F04C2240/60 ,  F16B2200/406 ,  Y10T403/473 ,  Y10T428/24322

摘要： A rotor 1 forming screw teeth is projectingly provided at its outer end 2 on the axis thereof with a center shaft 3. The center shaft 3 is provided at its outer end 4 with a smaller-diameter shaft 5 or a concaved fitting hole. A separate rotor shaft 6 which is to be fitted over the smaller-diameter shaft 5 or fitted into the concaved fitting hole is provided with another concaved fitting hole 7 or smaller-diameter shaft. A metal shaft around which synthetic resin is molded is formed at its peripheral surface with a spiral groove or corrugated groove in the opposite revolutional direction with respect to the revolutional direction of the screw rotor. The spiral groove is formed with smooth arc curved line connecting profiles of adjacent grooves. The shaft is provided with a step, and synthetic resin is molded around the shaft surface to form a screw rotor.

摘要翻译： 形成螺旋齿的转子1在其外端部2的轴线上以中心轴3突出地设置。中心轴3在其外端4处设置有较小直径的轴5或凹入的嵌合孔。 要安装在小直径轴5上或装配在凹形装配孔中的单独的转子轴6设置有另一个凹入的装配孔7或较小直径的轴。 在其圆周表面上形成有相对于螺杆转子的旋转方向在相反旋转方向上的螺旋形槽或波纹状槽的金属轴。 螺旋槽形成有相邻凹槽的平滑弧形曲线连接轮廓。 轴设置有台阶，合成树脂围绕轴表面模制以形成螺杆转子。

公开(公告)号：US6139298A

公开(公告)日：2000-10-31

申请号：US111446

申请日：1998-07-08

申请人： Yukihiro Kojima ,  Tetsuya Sasage ,  Noboru Toda

发明人： Yukihiro Kojima ,  Tetsuya Sasage ,  Noboru Toda

IPC分类号： F04C18/16 ,  F04C29/00

CPC分类号： F04C29/0071 ,  F04C18/16 ,  F04C2240/60 ,  Y10T403/4688 ,  Y10T403/473 ,  Y10T428/24322

摘要： A rotor 1 forming screw teeth is projectingly provided at its outer end 2 on the axis thereof with a center shaft 3. The center shaft 3 is provided at its outer end 4 with a smaller-diameter shaft 5 or a concaved fitting hole. A separate rotor shaft 6 which is to be fitted over the smaller-diameter shaft 5 or fitted into the concaved fitting hole is provided with another concaved fitting hole 7 or smaller-diameter shaft. A metal shaft around which synthetic resin is molded is formed at its peripheral surface with a spiral groove or corrugated groove in the opposite revolutional direction with respect to the revolutional direction of the screw rotor. The spiral groove is formed with smooth arc curved line connecting profiles of adjacent grooves. The shaft is provided with a step, and synthetic resin is molded around the shaft surface to form a screw rotor.

摘要翻译： 形成螺旋齿的转子1在其外端部2的轴线上以中心轴3突出地设置。中心轴3在其外端4处设置有较小直径的轴5或凹入的嵌合孔。 要安装在小直径轴5上或装配在凹形装配孔中的单独的转子轴6设置有另一个凹入的装配孔7或较小直径的轴。 在其圆周表面上形成有相对于螺杆转子的旋转方向在相反旋转方向上的螺旋形槽或波纹状槽的金属轴。 螺旋槽形成有相邻凹槽的平滑弧形曲线连接轮廓。 轴设置有台阶，合成树脂围绕轴表面模制以形成螺杆转子。

公开(公告)号：US06410535B1

公开(公告)日：2002-06-25

申请号：US09427579

申请日：1999-10-27

申请人： Atsunori Kashiwagi ,  Kazuya Shinozaki ,  Yoshihiko Nishio ,  Tomio Okamura ,  Noboru Toda ,  Ryuichi Kikkawa

发明人： Atsunori Kashiwagi ,  Kazuya Shinozaki ,  Yoshihiko Nishio ,  Tomio Okamura ,  Noboru Toda ,  Ryuichi Kikkawa

IPC分类号： A61K31495

CPC分类号： A61K31/505 ,  A61K31/519

摘要： It is an object of the present invention to provide a pharmaceutical composition for effectively preventing or improving diseases having vascular dysfunction associated with insulin resistance. The present invention provides pharmaceutical compositions for preventing or treating diseases having vascular dysfunction associated with insulin resistance, comprising as an active ingredient a compound of the formula (I): wherein R1 and R2 each represents a hydrogen atom or taken together with each other represent a single bond, while R3 represents —CH(OH)CH(OH)CH3, —CH(OCOCH3)CH(OCOCH3)CH3, —CH3, —CH2OH or a phenyl group when R1 and R2 each represents a hydrogen atom, or —COCH(OH)CH3 when R1 and R2 together represents a single bond, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明的目的是提供一种用于有效预防或改善与胰岛素抵抗相关的血管功能障碍的疾病的药物组合物。 本发明提供了用于预防或治疗与胰岛素抵抗相关的血管功能障碍的疾病的药物组合物，其包含作为活性成分的式（I）化合物：其中R 1和R 2各自表示氢原子或彼此一起代表 当R 1和R 2各自表示氢原子时，R 3表示-CH（OH）CH（OH）CH 3，-CH（OCOCH 3）CH（OCOCH 3）CH 3，-CH 3，-CH 2 OH或苯基，或-COCH （OH）CH 3，当R 1和R 2一起表示单键时，或其药学上可接受的盐。