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公开(公告)号：US20100258485A1
公开(公告)日：2010-10-14
申请号：US12681281
申请日：2007-10-02
IPC分类号： B01D15/10
CPC分类号： B01D15/203 , B01D15/20 , B01D15/24
摘要： A solution containing a target compound is passed through a trap column (14) to capture the target compound in the column (14). Thereafter, wash water is introduced in the trap column (14). Then, the setting of a six-port valve (7) is changed and an on/off valve (6) is opened to introduce nitrogen gas through a supply-side passage (8) in the trap column (14). In this stage, the nitrogen gas is warmed by means of a heat-exchange block (10), and the trap column (14) is warmed via a column rack (15). Any water remaining in the trap column (14) is initially thrust upwards by the nitrogen gas, to be extruded from an exit edge (14b) and discharged through a discharge-side passage (20). Furthermore, any water adhering to adsorbent or the inner wall surface of the trap column (14) is quickly vaporized and carried away by the nitrogen gas. In this manner, any water remaining in the trap column (14) can be rapidly removed, so that no water will be included in an eluate in the subsequent stage where a solvent with a strong elution power is introduced into the trap column (14) to collect the eluate. Thus, the eluate is rapidly vaporized and dried, so that the target compound in solid forms can be efficiently collected.
摘要翻译： 含有目标化合物的溶液通过捕集塔（14）以捕获柱（14）中的目标化合物。 此后，将洗涤水引入捕集塔（14）中。 然后，改变六口阀（7）的设定，开通开闭阀（6），将氮气通过捕集塔（14）内的供给侧通路（8）引入。 在这个阶段，氮气通过热交换块（10）加热，并且捕集塔（14）通过柱架（15）加热。 残留在捕集塔（14）中的任何水最初被氮气向上推动，从出口边缘（14b）挤出并通过排放侧通道（20）排出。 此外，附着于吸附剂或捕集塔（14）的内壁表面的任何水都被氮气迅速气化并带走。 以这种方式，可以快速除去残留在捕集塔（14）中的任何水，使得在后续阶段，洗脱液中不会含有水，其中具有强洗脱力的溶剂被引入捕集塔（14） 收集洗脱液。 因此，洗脱液迅速蒸发并干燥，从而能够有效地收集固体形式的目标化合物。
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公开(公告)号：US09259669B2
公开(公告)日：2016-02-16
申请号：US12681323
申请日：2007-10-02
IPC分类号： B01D15/24
CPC分类号： B01D15/24
摘要： Collection containers (17) are heated by head conduction from a container rack (18) with a heater (19) as the heat source. When an eluting solvent is supplied into a trap column (7) by a pump (5), an eluate containing a target compound exiting from the column (7) flows through a preparative separation passage (13) and drips from a solution nozzle (13a), and this solution is separated into fine droplets by a gas stream blowing from a gas ejection nozzle (15a). When a droplet touches an inner wall of the container (17), the volatile solvent immediately vaporizes, leaving the target compound precipitated in solid forms on the inner wall. Thus, the process of vaporizing and drying the eluate to collect the target compound is completed within a short period of time. This process can be performed online and hence is suitable for laborsaving.
摘要翻译： 收集容器（17）通过头管传导从具有作为热源的加热器（19）的容器架（18）加热。 当通过泵（5）将洗脱溶剂供应到捕集塔（7）中时，含有从柱（7）排出的目标化合物的洗脱液流过制备分离通道（13），并从溶液喷嘴（13a） ），并且通过从气体喷射喷嘴（15a）吹送的气流将该溶液分离成细小液滴。 当液滴接触容器（17）的内壁时，挥发性溶剂立即蒸发，使目标化合物以固体形式沉淀在内壁上。 因此，蒸发并干燥洗脱液以收集目标化合物的过程在短时间内完成。 该过程可以在线执行，因此适合于劳动保护。
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公开(公告)号：US08607620B2
公开(公告)日：2013-12-17
申请号：US12681276
申请日：2007-10-02
IPC分类号： G01N15/04
CPC分类号： B01D15/203 , B01D15/24
摘要： After a target compound is captured by an adsorbent within a trap column (7) held by a column rack (8) in a substantially vertical position and the column is filled with water to wash its inside, dichloromethane is slowly introduced from an inlet end (7a) on the lower side by a pump (5). The water within the trap column (7) is pushed upward by dichloromethane and exits from an outlet end (7b), to be disposed of via a two-way selector valve (12) and a disposal passage (14). Dichloromethane elutes the captured target compound. Therefore, when the eluate, which initially consists of water, changes via an emulsion to dichloromethane, the eluate contains an adequately high concentration of target compound. At this point, the two-way valve (12) is switched to a preparative separation passage (13). As a result, a solution that is adequately free from water and yet contains the target compound can be collected into a collection container (17), and the target compound in solid forms can be quickly obtained.
摘要翻译： 在由柱架（8）保持的捕集塔（7）中的吸附剂在基本垂直的位置捕获目标化合物，并且将柱填充水以洗涤其内部后，将二氯甲烷从入口端（ 7a）通过泵（5）在下侧。 捕集塔（7）内的水被二氯甲烷向上推，从出口端（7b）出来，通过二通换向阀（12）和废弃通道（14）进行排放。 二氯甲烷洗脱捕获的目标化合物。 因此，当最初由水组成的洗脱液通过乳液变成二氯甲烷时，洗脱液含有足够高浓度的目标化合物。 此时，将开闭阀（12）切换到制备分离通道（13）。 结果，可以将充分不含水并含有目标化合物的溶液收集到收集容器（17）中，并且可以快速获得固体形式的目标化合物。
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公开(公告)号：US20100281958A1
公开(公告)日：2010-11-11
申请号：US12681276
申请日：2007-10-02
IPC分类号： G01N30/02
CPC分类号： B01D15/203 , B01D15/24
摘要： After a target compound is captured by an adsorbent within a trap column (7) held by a column rack (8) in a substantially vertical position and the column is filled with water to wash its inside, dichloromethane is slowly introduced from an inlet end (7a) on the lower side by a pump (5). The water within the trap column (7) is pushed upward by dichloromethane and exits from an outlet end (7b), to be disposed of via a two-way selector valve (12) and a disposal passage (14). Dichloromethane elutes the captured target compound. Therefore, when the eluate, which initially consists of water, changes via an emulsion to dichloromethane, the eluate contains an adequately high concentration of target compound. At this point, the two-way valve (12) is switched to a preparative separation passage (13). As a result, a solution that is adequately free from water and yet contains the target compound can be collected into a collection container (17), and the target compound in solid forms can be quickly obtained.
摘要翻译： 在由柱架（8）保持的捕集塔（7）中的吸附剂在基本上垂直的位置捕获目标化合物之后，并且将柱填充水以洗涤其内部，将二氯甲烷从入口端（ 7a）通过泵（5）在下侧。 捕集塔（7）内的水被二氯甲烷向上推，从出口端（7b）出来，通过二通换向阀（12）和废弃通道（14）进行排放。 二氯甲烷洗脱捕获的目标化合物。 因此，当最初由水组成的洗脱液通过乳液变成二氯甲烷时，洗脱液含有足够高浓度的目标化合物。 此时，将开闭阀（12）切换到制备分离通道（13）。 结果，可以将充分不含水并含有目标化合物的溶液收集到收集容器（17）中，并且可以快速获得固体形式的目标化合物。
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公开(公告)号：US08968561B2
公开(公告)日：2015-03-03
申请号：US12681318
申请日：2007-10-02
CPC分类号： B01D15/20 , B01D15/166
摘要： A mixed liquid passage (31) is connected to a trapping passage (22) at a point upstream of a trap column (23). A mixture of a diluting liquid and an additive agent, which are respectively drawn and sent by pumps (35) and (36), is supplied into the mixed liquid passage (31). When an eluate containing a target compound is passed through the trap column (23), the eluate is diluted with the diluting liquid and hence its elution capability decreases, so that the target compound can be easily captured in the trap column (23). Meanwhile, the solubility of the mobile phase in the eluate decreases, causing not only the target component but also foreign compounds to more easily precipitate. However, their precipitation is prevented by the effect of the additive agent. Thus, clogging of the trap column (23) or pipes is prevented.
摘要翻译： 混合液体通道（31）在捕集塔（23）上游的一个点连接到捕集通道（22）。 将分别由泵（35）和（36）抽出并送出的稀释液和添加剂的混合物供给到混合液通路（31）中。 当含有目标化合物的洗脱液通过捕集塔（23）时，用稀释液稀释洗脱液，因此其洗脱能力降低，使得目标化合物可以容易地捕获在捕集塔（23）中。 同时，流动相在洗脱液中的溶解度降低，不仅引起目标成分，而且使外来化合物更容易沉淀。 然而，通过添加剂的作用可防止其沉淀。 因此，阻止了捕集塔（23）或管道的堵塞。
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公开(公告)号：US20100300627A1
公开(公告)日：2010-12-02
申请号：US12681323
申请日：2007-10-02
IPC分类号： B01D1/18
CPC分类号： B01D15/24
摘要： Collection containers (17) are heated by head conduction from a container rack (18) with a heater (19) as the heat source. When an eluting solvent is supplied into a trap column (7) by a pump (5), an eluate containing a target compound exiting from the column (7) flows through a preparative separation passage (13) and drips from a solution nozzle (13a), and this solution is separated into fine droplets by a gas stream blowing from a gas ejection nozzle (15a). When a droplet touches an inner wall of the container (17), the volatile solvent immediately vaporizes, leaving the target compound precipitated in solid forms on the inner wall. Thus, the process of vaporizing and drying the eluate to collect the target compound is completed within a short period of time. This process can be performed online and hence is suitable for laborsaving.
摘要翻译： 收集容器（17）通过头管传导从具有作为热源的加热器（19）的容器架（18）加热。 当通过泵（5）将洗脱溶剂供应到捕集塔（7）中时，含有从柱（7）排出的目标化合物的洗脱液流过制备分离通道（13），并从溶液喷嘴（13a） ），并且通过从气体喷射喷嘴（15a）吹送的气流将该溶液分离成细小液滴。 当液滴接触容器（17）的内壁时，挥发性溶剂立即蒸发，使目标化合物以固体形式沉淀在内壁上。 因此，蒸发并干燥洗脱液以收集目标化合物的过程在短时间内完成。 该过程可以在线执行，因此适合于劳动保护。
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公开(公告)号：US20100276350A1
公开(公告)日：2010-11-04
申请号：US12681318
申请日：2007-10-02
IPC分类号： B01D15/08
CPC分类号： B01D15/20 , B01D15/166
摘要： A mixed liquid passage (31) is connected to a trapping passage (22) at a point upstream of a trap column (23). A mixture of a diluting liquid and an additive agent, which are respectively drawn and sent by pumps (35) and (36), is supplied into the mixed liquid passage (31). When an eluate containing a target compound is passed through the trap column (23), the eluate is diluted with the diluting liquid and hence its elution capability decreases, so that the target compound can be easily captured in the trap column (23). Meanwhile, the solubility of the mobile phase in the eluate decreases, causing not only the target component but also foreign compounds to more easily precipitate. However, their precipitation is prevented by the effect of the additive agent. Thus, clogging of the trap column (23) or pipes is prevented.
摘要翻译： 混合液体通道（31）在捕集塔（23）上游的一个点连接到捕集通道（22）。 将分别由泵（35）和（36）抽出并送出的稀释液和添加剂的混合物供给到混合液通路（31）中。 当含有目标化合物的洗脱液通过捕集塔（23）时，用稀释液稀释洗脱液，因此其洗脱能力降低，使得目标化合物可以容易地捕获在捕集塔（23）中。 同时，流动相在洗脱液中的溶解度降低，不仅引起目标成分，而且使外来化合物更容易沉淀。 然而，通过添加剂的作用可防止其沉淀。 因此，阻止了捕集塔（23）或管道的堵塞。
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公开(公告)号：US08974666B2
公开(公告)日：2015-03-10
申请号：US12681281
申请日：2007-10-02
CPC分类号： B01D15/203 , B01D15/20 , B01D15/24
摘要： A solution containing a target compound is passed through a trap column (14) to capture the target compound in the column (14). Thereafter, wash water is introduced in the trap column (14). Then, the setting of a six-port valve (7) is changed and an on/off valve (6) is opened to introduce nitrogen gas through a supply-side passage (8) in the trap column (14). In this stage, the nitrogen gas is warmed by means of a heat-exchange block (10), and the trap column (14) is warmed via a column rack (15). Any water remaining in the trap column (14) is initially thrust upwards by the nitrogen gas, to be extruded from an exit edge (14b) and discharged through a discharge-side passage (20). Furthermore, any water adhering to adsorbent or the inner wall surface of the trap column (14) is quickly vaporized and carried away by the nitrogen gas. In this manner, any water remaining in the trap column (14) can be rapidly removed, so that no water will be included in an eluate in the subsequent stage where a solvent with a strong elution power is introduced into the trap column (14) to collect the eluate. Thus, the eluate is rapidly vaporized and dried, so that the target compound in solid forms can be efficiently collected.
摘要翻译： 含有目标化合物的溶液通过捕集塔（14）以捕获柱（14）中的目标化合物。 此后，将洗涤水引入捕集塔（14）中。 然后，改变六口阀（7）的设定，开通开闭阀（6），将氮气通过捕集塔（14）内的供给侧通路（8）引入。 在这个阶段，氮气通过热交换块（10）加热，并且捕集塔（14）通过柱架（15）加热。 残留在捕集塔（14）中的任何水最初被氮气向上推动，从出口边缘（14b）挤出并通过排放侧通道（20）排出。 此外，附着于吸附剂或捕集塔（14）的内壁表面的任何水都被氮气迅速气化并带走。 以这种方式，可以快速除去残留在捕集塔（14）中的任何水，使得在后续阶段，洗脱液中不会含有水，其中具有强洗脱力的溶剂被引入捕集塔（14） 收集洗脱液。 因此，洗脱液迅速蒸发并干燥，从而可以有效地收集固体形式的目标化合物。
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公开(公告)号：US08968563B2
公开(公告)日：2015-03-03
申请号：US13262524
申请日：2009-03-31
CPC分类号： G01N30/80 , B01D15/24 , G01N30/84 , G01N2030/8447 , G01N2030/8494
摘要： A fractionating and refining device includes a solution sending flow path for supplying a solution, including a fractionated target component, a gas supply flow path, a collecting vessel, a warming mechanism for warming the collecting vessel, and a probe formed by integrating tip end portions of the solution sending flow path and the gas supply flow path with each other. A lid of the vessel includes a solution inlet to which the tip end portion of the solution sending flow path is connected, gas inlets to which the tip end portion of the gas supply flow path is connected, and gas discharge ports connecting an inside and an outside of a vessel main body of the vessel.
摘要翻译： 分馏精制装置包括：供给溶液的溶液流动路径，包括分馏目标成分，气体供给流路，收集容器，加热收集容器的加温机构，以及通过将前端部 的溶液发送流路和供气流路彼此。 容器的盖子包括溶液输送流路的前端部连接的溶液入口，气体供给流路的前端部连接的气体入口和连接内部和内部的气体排出口 在船只的船主体外面。
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公开(公告)号：US10434436B2
公开(公告)日：2019-10-08
申请号：US13972036
申请日：2013-08-21
摘要： Provided is a gas-blowing vaporizing and drying device, which includes: a sample tube in the form of a double tube including an inner tube for a solution and an outer tube for a gas, the inner tube protruding from one end of the outer tube by length L; and a collection container including a container body and a lid provided with a protrusion sleeve tube, the protrusion sleeve tube including a coupling portion at an end to be located outside the container body and a sleeve portion of a length equal to or longer than L having an open end to be located inside the container body, the coupling portion being designed to be coupled to the aforementioned one end of the outer tube in an air-tight manner.
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