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公开(公告)号：US20110198272A1
公开(公告)日：2011-08-18
申请号：US13024701
申请日：2011-02-10
申请人： Tomoyuki YAMAZAKI
发明人： Tomoyuki YAMAZAKI
IPC分类号： B01D15/08
CPC分类号： G01N30/34 , B01D15/163 , B01D15/166 , B01D15/247 , G01N30/08 , G01N30/20 , G01N30/26 , G01N30/32 , G01N30/462 , G01N30/80 , G01N30/82 , G01N2030/085 , G01N2030/202 , G01N2030/8411 , G01N2030/8429 , G01N2030/8494
摘要： The present invention aims at providing a preparative separation/purification system for vaporizing an eluate in a short period of time, while enhancing the efficiency of collecting the target substance by accelerating the initiation of collecting the eluate. The preparative separation/purification system in which water containing a target component is passed through a column 8 to capture the target component in the column 8 and then a solvent is passed through it to collect the target compound, includes: a liquid supply means 7 for supplying a solvent to the column 8, with the target component captured in the column 8, while the column 8 is vertically held with the inlet end thereof directed downwards and the discharge end thereof directed upwards, the solvent having a low solubility to water and having a specific gravity greater than that of water; a passage selection means 12 for changing the passage configuration so that a solution exiting from the column 8 is selectively sent to either a collection passage 13 or a disposal passage 14; a passage control means 30 for controlling the passage selection means 12 so that, when water exits from the column 8, the water is sent to the disposal passage 14, and when solution containing solvent exits from the column 8, the solution is sent to the collection passage 13; and a flow rate control means 30 for controlling so that the water is supplied at a first flow rate to the disposal passage 14, and the solution containing solvent is supplied to the collection passage 13 at a flow rate lower than the first flow rate.
摘要翻译： 本发明旨在提供一种用于在短时间内蒸发洗脱液的制备分离/纯化系统，同时通过加速收集洗脱液的开始提高收集目标物质的效率。 将含有目标成分的水通过塔8捕获塔8中的目标成分，然后通过溶剂以收集目标化合物的制备型分离/纯化系统包括：液体供应装置7，用于 向柱8供应溶剂，其中目标组分捕获在塔8中，同时柱8垂直保持，其入口端向下指向其排出端向上，溶剂对水的溶解度低，并且具有 比重大于水; 用于改变通道构造的通道选择装置12，使得从塔8排出的溶液被选择性地送到收集通道13或处理通道14; 用于控制通道选择装置12的通道控制装置30，使得当水从塔8排出时，水被送到处理通道14，并且当含有溶剂的溶液从塔8排出时，溶液被送到 收集通道13; 以及流量控制装置30，用于控制水以第一流量供给到处理通道14，并且含有溶剂的溶液以低于第一流量的流量供给到收集通道13。
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公开(公告)号：US20100288026A1
公开(公告)日：2010-11-18
申请号：US12517951
申请日：2007-12-06
申请人： Zhi Xu
发明人： Zhi Xu
CPC分类号： G01N30/74 , G01N30/84 , G01N2030/847 , G01N2030/8494
摘要： A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector
摘要翻译： 用于液相色谱检测器的流量控制器。 流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。 控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。 流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流
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3.发明授权公开(公告)号：US07678276B2
公开(公告)日：2010-03-16
申请号：US11478699
申请日：2006-07-03
申请人： Akihiro Matabe
发明人： Akihiro Matabe
IPC分类号： B01D15/08
CPC分类号： B01D45/16 , B01D15/40 , B01D19/0005 , B01D19/0015 , G01N2030/8494
摘要： A method comprising liquefying a gas to thereby obtain a liquefied gas; injecting a sample into a mobile phase containing a solvent and a supercritical fluid formed from the liquefied gas; passing this mobile phase through a column so that the mobile phase containing desired substance is divided into the solvent and the gas; and separating the desired substance from the solvent, wherein when the pressure of the gas divided from the mobile phase is higher than the pressure of the gas fed for formation of the liquefied gas from gas supply device, the gas divided from the mobile phase is liquefied. Further, there is provided a vapor liquid separator for use in the method.
摘要翻译： 一种包括液化气体从而获得液化气体的方法; 将样品注入含有由液化气体形成的溶剂和超临界流体的流动相中; 使该流动相通过柱，使含有所需物质的流动相分成溶剂和气体; 并将所需物质与溶剂分离，其中当从流动相中分离的气体的压力高于从气体供应装置形成液化气体的气体的压力时，从流动相中分离的气体被液化 。 此外，提供了一种用于该方法的蒸气分离器。
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公开(公告)号：US07006218B2
公开(公告)日：2006-02-28
申请号：US09392757
申请日：1999-09-07
申请人： James M. Anderson, Jr. , Raaidah Saari-Nordhaus , Bart C. Benedict , Melissa Wilcox , Ronald Krob , Arnold Williams
发明人： James M. Anderson, Jr. , Raaidah Saari-Nordhaus , Bart C. Benedict , Melissa Wilcox , Ronald Krob , Arnold Williams
IPC分类号： G01N15/06
CPC分类号： G01N27/44721 , G01N30/10 , G01N30/74 , G01N2030/8464 , G01N2030/847 , G01N2030/8494 , G01N2030/3046 , G01N21/47
摘要： The present invention is directed to a system for converting between single flow and split flow evaporative light scattering detection devices for detecting samples in a mobile phase. Included in the system is a evaporative light scattering detection device, a low temperature adaptor, and a connection tube for providing a fluid connection between the evaporative light scattering detection device and the low temperature adaptor.
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公开(公告)号：US08968563B2
公开(公告)日：2015-03-03
申请号：US13262524
申请日：2009-03-31
CPC分类号： G01N30/80 , B01D15/24 , G01N30/84 , G01N2030/8447 , G01N2030/8494
摘要： A fractionating and refining device includes a solution sending flow path for supplying a solution, including a fractionated target component, a gas supply flow path, a collecting vessel, a warming mechanism for warming the collecting vessel, and a probe formed by integrating tip end portions of the solution sending flow path and the gas supply flow path with each other. A lid of the vessel includes a solution inlet to which the tip end portion of the solution sending flow path is connected, gas inlets to which the tip end portion of the gas supply flow path is connected, and gas discharge ports connecting an inside and an outside of a vessel main body of the vessel.
摘要翻译： 分馏精制装置包括：供给溶液的溶液流动路径，包括分馏目标成分，气体供给流路，收集容器，加热收集容器的加温机构，以及通过将前端部 的溶液发送流路和供气流路彼此。 容器的盖子包括溶液输送流路的前端部连接的溶液入口，气体供给流路的前端部连接的气体入口和连接内部和内部的气体排出口 在船只的船主体外面。
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公开(公告)号：US20100002229A1
公开(公告)日：2010-01-07
申请号：US12325890
申请日：2008-12-01
申请人： David W. Larsen , Zhi Xu
发明人： David W. Larsen , Zhi Xu
IPC分类号： G01N21/53
CPC分类号： G01N30/74 , G01N21/0303 , G01N21/53 , G01N2030/847 , G01N2030/8494 , G01N2201/0642 , G01N21/47
摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.
摘要翻译： 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。
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公开(公告)号：US20100000943A1
公开(公告)日：2010-01-07
申请号：US12312890
申请日：2007-12-08
申请人： William W. Carson , Sidney Bourne
发明人： William W. Carson , Sidney Bourne
IPC分类号： B01D1/00
CPC分类号： B01D1/222 , B01D1/0094 , B01D1/16 , B01D19/0026 , B01D19/0052 , B01D19/0057 , G01N30/84 , G01N2030/743 , G01N2030/8494 , Y10T436/111666 , Y10T436/255 , Y10T436/25875
摘要： Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets. When the droplets are sufficiently small, Stokes drag from the exiting solvent vapor carries the droplets out through the center of the cylindrical cavity. After exiting, the superheated solvent vapor further dries the droplets. Solvent vapor is removed by condensation onto a cooled surface. A freezing point reducing agent may be added to improve removal of solvent condensate. Stokes drag from a non-condensable gas maintains the dried droplets in suspension. This suspension travels through an orifice that focuses the impaction of the dried droplets onto the optical surface for infrared analysis. The deposition surface is in an evacuated chamber and is temperature controlled to freeze liquid solutes yet allowing sublimation of residual solvent.
摘要翻译： 公开了在保持溶解的基底的时间分辨率的同时使流动的液体流脱溶的方法和装置。 一种新颖的小型自调节喷雾干燥器保持时间分辨率，同时对液相色谱洗脱液流进行脱溶剂并将溶质沉积在光学表面上用于红外光谱分析。 将液体洗脱液泵送通过加热的雾化器以产生含有液体和溶剂蒸气的溶质的高速射流。 该射流沿周向定向在热的圆柱形空腔内。 离心力使较大的液滴沿腔的外径行进。 加热空腔表面以使液滴沸腾。 薄膜沸腾减少与空腔表面的液滴接触，从而将溶质保留在液滴中。 通过控制溶剂从液滴蒸发的压力来限制溶质温度。 当液滴足够小时，来自离开的溶剂蒸气的斯托克斯阻力将液滴通过圆柱形空腔的中心带出。 离开后，过热溶剂蒸气进一步干燥液滴。 溶剂蒸气通过冷凝除去冷却的表面。 可以加入凝固点还原剂以改善溶剂冷凝物的去除。 来自不可冷凝气体的斯托克斯阻力将干燥的液滴保持在悬浮状态。 该悬浮液通过孔将干燥小滴的冲击聚焦到光学表面上用于红外分析。 沉积表面处于抽真空室中并进行温度控制以冷冻液体溶质，同时允许残留溶剂升华。
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公开(公告)号：US07268881B2
公开(公告)日：2007-09-11
申请号：US10780278
申请日：2004-02-17
申请人： David W. Larsen , Zhi Xu
发明人： David W. Larsen , Zhi Xu
IPC分类号： G01N21/00
CPC分类号： G01N30/74 , G01N21/0303 , G01N21/53 , G01N2030/847 , G01N2030/8494 , G01N2201/0642 , G01N21/47
摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.
摘要翻译： 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。
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公开(公告)号：US20050179904A1
公开(公告)日：2005-08-18
申请号：US10780278
申请日：2004-02-17
申请人： David Larsen , Zhi Xu
发明人： David Larsen , Zhi Xu
CPC分类号： G01N30/74 , G01N21/0303 , G01N21/53 , G01N2030/847 , G01N2030/8494 , G01N2201/0642 , G01N21/47
摘要： The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.
摘要翻译： 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。
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公开(公告)号：US6122055A
公开(公告)日：2000-09-19
申请号：US318461
申请日：1999-05-25
CPC分类号： G01N30/74 , G01N21/4738 , G01N2030/847 , G01N2030/8494
摘要： An evaporative light scattering detector (1) has a solvent nebulizer (4) through which an atomised spray of solute solvent solution passes, a heated evaporation chamber (5) and a detector system (6). A diffuser trapping device (7), supported by fine wires, is positioned in the evaporation chamber(5) at about two fifths of the height of the chamber from the top. The diffuser trapping device (7) is made from randomly coiled stainless steel ribbon which gives it a large surface area. The detection system (6) is positioned at the bottom of the evaporation chamber through which a beam of collimated light passes and is scattered by the solvent and detected by a light sensitive device (14). The diffuser trapping device (7) aids evaporation of the solvent and prevents large particles from travelling further down the evaporation chamber (5).
摘要翻译： 蒸发光散射检测器（1）具有溶剂雾化器（4），溶质溶剂溶液的雾化喷雾通过该溶剂喷雾器，加热的蒸发室（5）和检测器系统（6）。 由细线支撑的扩散器捕集装置（7）位于蒸发室（5）中，距离顶部约为室高度的五分之二。 扩散器捕集装置（7）由随机卷绕的不锈钢带制成，使其具有大的表面积。 检测系统（6）位于蒸发室的底部，准直光束通过该底部通过溶剂并被光敏装置（14）检测。 扩散器捕集装置（7）有助于溶剂的蒸发并防止大颗粒进一步向下蒸发室（5）。
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