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1.发明申请公开(公告)号：US20140329739A1
公开(公告)日：2014-11-06
申请号：US14112064
申请日：2012-01-17
申请人： Yuxin Chen , Mingxia Chen , Yibing Huang , Yang Li , Yong Wang , Lili Qu , Wenren Wang
发明人： Yuxin Chen , Mingxia Chen , Yibing Huang , Yang Li , Yong Wang , Lili Qu , Wenren Wang
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4723
摘要： Disclosed are an antibiotic peptide and the like, having an amino acid sequence of Ac-Phe-Lys-Lys-Leu-Lys-Lys-Leu-Phe-Ser-Lys-Leu-Trp-Asn-Trp-Lys-NH2 (SEQ ID No:1). Also disclosed are a method of preparing the antibiotic peptide and the like, and the application thereof. The antibiotic peptide and the like synthesized by the solid phase synthetic technology according to the present invention can be used as a formulation against microbial infection and as alternate or adjuvant medicaments of antibiotics in the prior art.
摘要翻译： 公开了具有Ac-Phe-Lys-Lys-Leu-Lys-Lys-Leu-Phe-Ser-Lys-Leu-Trp-Asn-Trp-Lys-NH2（SEQ）的氨基酸序列的抗生素肽等 身份证号：1）。 还公开了制备抗生素肽等的方法及其应用。 通过根据本发明的固相合成技术合成的抗生素肽等可以用作抗微生物感染的制剂，以及作为现有技术中抗生素的替代或辅助药物。
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2.发明授权公开(公告)号：US09273095B2
公开(公告)日：2016-03-01
申请号：US14112064
申请日：2012-01-17
申请人： Yuxin Chen , Mingxia Chen , Yibing Huang , Yang Li , Yong Wang , Lili Qu , Wenren Wang
发明人： Yuxin Chen , Mingxia Chen , Yibing Huang , Yang Li , Yong Wang , Lili Qu , Wenren Wang
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4723
摘要： Disclosed are an antibiotic peptide and the like, having an amino acid sequence of Ac-Phe-Lys-Lys-Leu-Lys-Lys-Leu-Phe-Ser-Lys-Leu-Trp-Asn-Trp-Lys-NH2 (SEQ ID No:2). Also disclosed are a method of preparing the antibiotic peptide and the like, and the application thereof. The antibiotic peptide and the like synthesized by the solid phase synthetic technology according to the present invention can be used as a formulation against microbial infection and as alternate or adjuvant medicaments of antibiotics in the prior art.
摘要翻译： 公开了具有Ac-Phe-Lys-Lys-Leu-Lys-Lys-Leu-Phe-Ser-Lys-Leu-Trp-Asn-Trp-Lys-NH2（SEQ）的氨基酸序列的抗生素肽等 身份证号：2）。 还公开了制备抗生素肽等的方法及其应用。 通过根据本发明的固相合成技术合成的抗生素肽等可以用作抗微生物感染的制剂，以及作为现有技术中抗生素的替代或辅助药物。
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公开(公告)号：US09346865B2
公开(公告)日：2016-05-24
申请号：US13588990
申请日：2012-08-17
申请人： Robert S. Hodges , Yuxin Chen
发明人： Robert S. Hodges , Yuxin Chen
CPC分类号： C07K14/4723 , A61K38/00
摘要： Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, specificity, resistance to degradation desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides result from structure-based rational design relating to antimicrobial peptide V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Some peptides contain one or more (or all) amino acids in the D configuration. Compositions disclosed herein have useful clinical potential as antibiotics including broad spectrum antibiotics.
摘要翻译： 本文公开了具有有用的，改进的或优异的性质的新型抗微生物肽，例如抗微生物活性，特异性，抗降解性，所需溶血活性水平以及针对广泛范围的微生物（包括革兰氏阴性和革兰氏阳性菌等）的治疗指数 具有脂质双层膜的细胞或结构成分的生物体。 还提供了制备和使用这些肽来控制微生物生长的方法和用于治疗或预防由这种微生物引起的感染的药物组合物。 某些肽由与抗微生物肽V681相关的基于结构的合理设计产生，在非极性或极性面上的肽中心附近具有单个D- / L-氨基酸置换或带电残基取代。 一些肽在D构型中含有一个或多个（或全部）氨基酸。 本文公开的组合物作为抗生素包括广谱抗生素具有有用的临床潜力。
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公开(公告)号：US20130035469A1
公开(公告)日：2013-02-07
申请号：US13588990
申请日：2012-08-17
申请人： Robert S. Hodges , Yuxin Chen
发明人： Robert S. Hodges , Yuxin Chen
CPC分类号： C07K14/4723 , A61K38/00
摘要： Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, specificity, resistance to degradation desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides result from structure-based rational design relating to antimicrobial peptide V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Some peptides contain one or more (or all) amino acids in the D configuration. Compositions disclosed herein have useful clinical potential as antibiotics including broad spectrum antibiotics.
摘要翻译： 本文公开了具有有用的，改进的或优异的性质的新型抗微生物肽，例如抗微生物活性，特异性，抗降解性，所需溶血活性水平以及针对广泛范围的微生物（包括革兰氏阴性和革兰氏阳性菌等）的治疗指数 具有脂质双层膜的细胞或结构成分的生物体。 还提供了制备和使用这些肽来控制微生物生长的方法和用于治疗或预防由这种微生物引起的感染的药物组合物。 某些肽由与抗微生物肽V681相关的基于结构的合理设计产生，在非极性或极性面上的肽中心附近具有单个D- / L-氨基酸置换或带电残基取代。 一些肽在D构型中含有一个或多个（或全部）氨基酸。 本文公开的组合物作为包括广谱抗生素的抗生素具有有用的临床潜力。
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公开(公告)号：US08252737B2
公开(公告)日：2012-08-28
申请号：US11721915
申请日：2005-12-15
IPC分类号： A61K38/16
CPC分类号： C07K14/4723 , A61K38/00
摘要： Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation. Compositions disclosed herein have useful clinical potential as antibiotics including broad spectrum antibiotics.
摘要翻译： 本文公开了具有有用的，改进的或优异的性质的新型抗微生物肽，例如抗微生物活性，理想的溶血活性水平和针对广泛范围的微生物（包括革兰氏阴性和革兰氏阳性细菌和其他生物）的治疗指数，其具有细胞或 脂质双层膜的结构组分。 还提供了制备和使用这些肽来控制微生物生长的方法和用于治疗或预防由这种微生物引起的感染的药物组合物。 使用与抗微生物肽V681相关的基于结构的合理设计，在非极性或极性面上的肽中心附近具有单个D- / L-氨基酸置换或带电残基取代的某些肽被公开。 还公开了具有D构型中的一个或多个氨基酸的肽，包括具有D构型中所有氨基酸的肽。 本文中修饰的肽类似物可以证明一种或多种性质，例如改善的抗微生物活性，特异性和抗降解性。 本文公开的组合物作为抗生素包括广谱抗生素具有有用的临床潜力。
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公开(公告)号：US20090005300A1
公开(公告)日：2009-01-01
申请号：US11721915
申请日：2005-12-15
IPC分类号： A61K38/16 , C07K14/00 , A01N37/18 , A61P31/10 , A61P31/12 , A61P33/02 , A61P31/04 , A01P1/00
CPC分类号： C07K14/4723 , A61K38/00
摘要： Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides are disclosed utilizing a structure-based rational design relating to an antimicrobial peptide, V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Also disclosed are peptides with one or more amino acids in the D configuration, including peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation. Compositions disclosed herein have useful clinical potential as antibiotics including broad spectrum antibiotics.
摘要翻译： 本文公开了具有有用的，改进的或优异的性质的新型抗微生物肽，例如抗微生物活性，理想的溶血活性水平和针对广泛范围的微生物（包括革兰氏阴性和革兰氏阳性细菌和其他生物）的治疗指数，其具有细胞或 脂质双层膜的结构组分。 还提供了制备和使用这些肽来控制微生物生长的方法和用于治疗或预防由这种微生物引起的感染的药物组合物。 使用与抗微生物肽V681相关的基于结构的合理设计，在非极性或极性面上的肽中心附近具有单个D- / L-氨基酸置换或带电残基取代的某些肽被公开。 还公开了具有D构型中的一个或多个氨基酸的肽，包括具有D构型中所有氨基酸的肽。 本文中修饰的肽类似物可以证明一种或多种性质，例如改善的抗微生物活性，特异性和抗降解性。 本文公开的组合物作为抗生素包括广谱抗生素具有有用的临床潜力。
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