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    Method for improving morbid dermatitis by inhibiting activity of a plasminogen activator in the skin
    1.
    发明授权
    Method for improving morbid dermatitis by inhibiting activity of a plasminogen activator in the skin 有权
    通过抑制皮肤中纤溶酶原激活物的活性来改善病态皮炎的方法

    公开(公告)号：US06649179B2

    公开(公告)日：2003-11-18

    申请号：US10202015

    申请日：2002-07-25

    申请人： Yuzo Yoshida ,  Eriko Kawai

    发明人： Yuzo Yoshida ,  Eriko Kawai

    IPC分类号： A61K700

    CPC分类号： A61Q19/00 ,  A61K8/27 ,  A61K33/30 ,  A61K2800/70 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  Y10S514/859 ,  Y10S514/861

    摘要： The present invention relates to a plasminogen activator inhibitor, an external preparation for skin comprising the same, a method for improving rough skin and in particular, for improvement of an effective inorganic component. A plasminogen activator inhibitor contains a specific zinc oxide which adsorbs a plasminogen activator and effectively inhibits its activity. When it is used as an external preparation for skin, excellent improvement of rough skin is obtainable. Further, when silica-coated zinc oxide is applied as an external preparation for skin, excellent improvement effect and prevention effect for rough skin are obtainable without an intolerance sensitivity reaction in the case of morbid dermatitis such as atopic dermatitis or pimpled skin.

    摘要翻译： 本发明涉及纤溶酶原激活物抑制剂，包含其的外用皮肤外用剂，改善粗糙皮肤的方法，特别涉及改善有效无机成分。 纤溶酶原激活物抑制剂含有吸附纤溶酶原激活物并有效抑制其活性的特定氧化锌。 当用作皮肤的外用剂时，可以获得粗糙皮肤的极好的改善。 此外，作为皮肤外用剂，涂敷二氧化硅被覆氧化锌时，可以获得对皮肤粗糙等病变性皮肤病或皮肤刺激性皮肤的病态敏感性反应的粗糙皮肤的优异的改善效果和防止效果。

    Oily skin preparation for external use
    3.
    发明申请
    Oily skin preparation for external use 有权
    油性皮肤准备外用

    公开(公告)号：US20060110414A1

    公开(公告)日：2006-05-25

    申请号：US10540632

    申请日：2003-12-26

    申请人： Yukimitsu Suda ,  Mari Yoshida ,  Eriko Kawai ,  Shigeru Mugikura

    发明人： Yukimitsu Suda ,  Mari Yoshida ,  Eriko Kawai ,  Shigeru Mugikura

    IPC分类号： A61K8/27 ,  A61K8/81 ,  A61K8/73

    CPC分类号： A61K8/81 ,  A61K8/0241 ,  A61K8/27 ,  A61K8/88 ,  A61K8/891 ,  A61K8/894 ,  A61K2800/412 ,  A61K2800/621 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q19/005 ,  A61Q19/007

    摘要： The objective of this invention is to provide an oily external composition for skin having an excellent rough skin recovering/preventing effect, and wherein powder is well dispersed in oil. An oily external composition for skin of this invention is characterized in that comprising a complex powder (the surface of lipophilic base powder is covered with zinc oxide) and an oil component, wherein said complex powder is dispersed in said oil component, and wherein zeta-potential of said lipophilic base powder is negative value at pH on skin. It is preferable that zeta-potential of said lipophilic base powder is −10 mV or less at pH on skin. It is preferable that said lipophilic base powder is swelled in the condition of dispersing in oil. Above-mentioned external composition can be used as a rough skin recovering composition and a sensitive skin caring composition.

    摘要翻译： 本发明的目的是提供具有优异的粗糙皮肤恢复/防止效果的油性皮肤外用组合物，其中粉末分散在油中。 本发明的油性皮肤外用组合物的特征在于，含有复合粉末（亲油性基底粉末的表面被氧化锌覆盖）和油成分，其中所述复合粉末分散在所述油性成分中， 所述亲油性基础粉末的潜力在皮肤pH下为负值。 所述亲油性基础粉末的ζ电位优选在皮肤pH下为-10mV以下。 所述亲油性基础粉末优选在分散在油中的状态下溶胀。 上述外用组合物可用作粗糙皮肤恢复组合物和敏感的护肤组合物。

    Composite powders and skin preparations for external use containing the same
    4.
    发明授权
    Composite powders and skin preparations for external use containing the same 有权
    复合粉末和外用皮肤制剂

    公开(公告)号：US08092834B2

    公开(公告)日：2012-01-10

    申请号：US10481852

    申请日：2002-06-28

    申请人： Norinobu Yoshikawa ,  Kenichi Sakuma ,  Katsuki Ogawa ,  Satoshi Tomomasa ,  Eriko Kawai ,  Hiroyuki Yokoyama ,  Yukimitsu Suda

    发明人： Norinobu Yoshikawa ,  Kenichi Sakuma ,  Katsuki Ogawa ,  Satoshi Tomomasa ,  Eriko Kawai ,  Hiroyuki Yokoyama ,  Yukimitsu Suda

    IPC分类号： A61K9/14 ,  A61K9/18

    CPC分类号： A61K8/891 ,  A61K8/02 ,  A61K8/0204 ,  A61K8/022 ,  A61K8/11 ,  A61K8/25 ,  A61K8/27 ,  A61K8/89 ,  A61K38/49 ,  A61K2800/612 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/005

    摘要： A complex powder comprising an adsorption site and operation site, wherein said adsorption site attracts or adsorbs a specific enzyme, wherein said operation site inhibits or activates said enzyme, and wherein each of the both sites are appeared on the surface of the powder. In the complex powder described above, it is preferable that ζ-potential of the adsorption site at the pH employed is negative value, wherein said adsorption site attracts or adsorbs the specific enzyme whose ζ-potential is positive value, and wherein said adsorption site inhibits or activates said specific enzyme. And it is preferable that said adsorption site has ζ-potential at pH7.5 of −10 mV or below.In the complex powder described above, it is preferable that said specific enzyme is a plasminogen activator, and the operation site inhibits said plasminogen activator.The complex powder described above can be used as an external composition for improving a rough skin and an external composition for a sensitive skin.

    摘要翻译： 包含吸附位点和操作部位的复合粉末，其中所述吸附部位吸引或吸附特定酶，其中所述操作部位抑制或激活所述酶，并且其中两个部位中的每一个出现在粉末的表面上。 在上述复合粉末中，优选吸附部位在所用pH下的ζ-电位为负值，其中所述吸附部位吸引或吸附ζ-电位为正值的特异性酶，其中所述吸附位点抑制 或激活所述特异性酶。 并且所述吸附部位优选在pH7.5为-10mV以下的ζ-电位。 在上述复合粉末中，优选所述特异性酶是纤溶酶原激活剂，操作部位抑制所述纤溶酶原激活剂。 上述复合粉末可以用作改善粗糙皮肤的外用组合物和用于敏感皮肤的外用组合物。

    Oily skin preparation for external use
    5.
    发明授权
    Oily skin preparation for external use 有权
    油性皮肤准备外用

    公开(公告)号：US08062671B2

    公开(公告)日：2011-11-22

    申请号：US10540632

    申请日：2003-12-26

    申请人： Yukimitsu Suda ,  Mari Yoshida ,  Eriko Kawai ,  Shigeru Mugikura

    发明人： Yukimitsu Suda ,  Mari Yoshida ,  Eriko Kawai ,  Shigeru Mugikura

    IPC分类号： A61K9/16 ,  A61K8/02 ,  A61K9/50

    CPC分类号： A61K8/81 ,  A61K8/0241 ,  A61K8/27 ,  A61K8/88 ,  A61K8/891 ,  A61K8/894 ,  A61K2800/412 ,  A61K2800/621 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q19/005 ,  A61Q19/007

    摘要： The objective of this invention is to provide an oily external composition for skin having an excellent rough skin recovering/preventing effect, and wherein powder is well dispersed in oil. An oily external composition for skin of this invention is characterized in that comprising a complex powder (the surface of lipophilic base powder is covered with zinc oxide) and an oil component, wherein said complex powder is dispersed in said oil component, and wherein zeta-potential of said lipophilic base powder is negative value at pH on skin. It is preferable that zeta-potential of said lipophilic base powder is −10 mV or less at pH on skin. It is preferable that said lipophilic base powder is swelled in the condition of dispersing in oil. Above-mentioned external composition can be used as a rough skin recovering composition and a sensitive skin caring composition.

    摘要翻译： 本发明的目的是提供具有优异的粗糙皮肤恢复/防止效果的油性皮肤外用组合物，其中粉末分散在油中。 本发明的油性皮肤外用组合物的特征在于，含有复合粉末（亲油性基底粉末的表面被氧化锌覆盖）和油成分，其中所述复合粉末分散在所述油性成分中， 所述亲油性基础粉末的潜力在皮肤pH下为负值。 所述亲油性基础粉末的ζ电位优选在皮肤pH下为-10mV以下。 所述亲油性基础粉末优选在分散在油中的状态下溶胀。 上述外用组合物可用作粗糙皮肤恢复组合物和敏感的护肤组合物。