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公开(公告)号：US20110070317A1
公开(公告)日：2011-03-24
申请号：US12992468
申请日：2009-05-13
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K33/24 , A61P35/00 , C07D471/04 , A61K31/437 , A61K31/7068 , A61K31/4745 , A61K31/513 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/498 , A61K31/5377 , A61K31/55
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US08178131B2
公开(公告)日：2012-05-15
申请号：US12992468
申请日：2009-05-13
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K33/24 , A61K31/437 , A61K31/7068 , A61K31/4745 , A61K31/513 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/498 , A61K31/5377 , A61K31/55 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US08841304B2
公开(公告)日：2014-09-23
申请号：US12812447
申请日：2009-01-08
申请人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
发明人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
IPC分类号： C07D471/04 , A61K31/496
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20100324041A1
公开(公告)日：2010-12-23
申请号：US12812447
申请日：2009-01-08
申请人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
发明人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/496 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula, (I).
摘要翻译： 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。 公式，（一）。
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公开(公告)号：US08372842B2
公开(公告)日：2013-02-12
申请号：US12812448
申请日：2009-01-08
申请人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
发明人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
IPC分类号： A61K31/496 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20100280043A1
公开(公告)日：2010-11-04
申请号：US12812448
申请日：2009-01-08
申请人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
发明人： James F. Blake , Indrani W. Gunawardana , Yvan Le Huerou , Peter J. Mohr , Eli M. Wallace , Bin Wang
IPC分类号： A61K31/496 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US08545897B2
公开(公告)日：2013-10-01
申请号：US13425186
申请日：2012-03-20
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K31/4545 , A61K31/437 , A61K31/497 , A61K31/506 , A61K33/24 , A61K31/513 , A61K31/444 , A61K31/501 , A61P35/00
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20130045286A1
公开(公告)日：2013-02-21
申请号：US13425186
申请日：2012-03-20
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K31/4545 , A61K31/437 , A61K31/497 , A61K31/506 , A61P35/00 , A61K31/498 , A61K31/7068 , A61K31/4745 , A61K33/24 , A61K31/513 , A61K31/444 , A61K31/501
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20140005213A1
公开(公告)日：2014-01-02
申请号：US14001657
申请日：2012-02-24
申请人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
发明人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
IPC分类号： C07D471/04 , C07D491/048 , C07D487/10 , C07D487/04
CPC分类号： C07D471/04 , C07D401/06 , C07D487/04 , C07D487/10 , C07D491/048 , C07D519/00
摘要： Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要翻译： R 1，R 2，R 3，R 4和R 10具有本说明书中给出的含义的式I化合物是可用于治疗由PIM-1和/或PIM-2和/或PIM-2介导的疾病的受体酪氨酸抑制剂， 3激酶。
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公开(公告)号：US08889704B2
公开(公告)日：2014-11-18
申请号：US14001657
申请日：2012-02-24
申请人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
发明人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
IPC分类号： C07D471/04 , C07D487/04 , C07D487/10 , C07D491/048 , C07D401/06 , C07D519/00
CPC分类号： C07D471/04 , C07D401/06 , C07D487/04 , C07D487/10 , C07D491/048 , C07D519/00
摘要： Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要翻译： R 1，R 2，R 3，R 4和R 10具有本说明书中给出的含义的式I化合物是可用于治疗由PIM-1和/或PIM-2和/或PIM-2介导的疾病的受体酪氨酸抑制剂， 3激酶。
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