-
1.发明申请CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN 审中-公开硝基磷酸三钙磷酸钙/钠盐作为HEMOGLOBIN的独立效应公开(公告)号：US20120010174A1
公开(公告)日：2012-01-12
申请号：US13176499
申请日：2011-07-05
IPC分类号： A61K31/6615 , A61P7/00 , A61P35/02 , A61P25/28 , C07F9/6574 , A61P35/00
CPC分类号： A61K31/661 , A61K31/6615 , C07F9/65746
摘要： The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
摘要翻译： 本发明涉及三水磷酸肌醇的混合钙/钠盐，其制备方法和使用方法。 混合的钙/钠盐可以是三磷酸肌醇的单钙四钠盐。 使用方法包括以有效量施用上述盐，以治疗由与肺或循环系统功能不足相关的缺氧或其它病症所引起的疾病，例如各种类型的癌症和阿尔茨海默氏病。
-
公开(公告)号：US20130059820A1
公开(公告)日：2013-03-07
申请号：US13426148
申请日：2012-03-21
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的修饰的肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
-
公开(公告)号：US20110281825A1
公开(公告)日：2011-11-17
申请号：US13024922
申请日：2011-02-10
IPC分类号： A61K31/683 , A61P7/00 , A61P9/10
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的修饰的肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
-
4.发明申请公开(公告)号：US20120003327A1
公开(公告)日：2012-01-05
申请号：US13033363
申请日：2011-02-23
IPC分类号： A61K31/6615 , A61P35/00 , A61K33/24
CPC分类号： A61K31/6615 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/665 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be used to reduce the amount of a second chemotherapeutic drug required for anticancer activity. In addition, ITPP enhances immune response and treats hyperproliferative disorders.
摘要翻译： 肌醇三磷酸（ITPP）导致肿瘤血管系统的正常化，并且当在部分血管形成后施用第二化学治疗剂时，是特别有效的癌症治疗。 ITPP也单独或组合治疗多重耐药性癌症。 ITPP也可用于减少抗癌活性所需的第二化疗药物的量。 此外，ITPP增强免疫反应并治疗过度增殖性疾病。
-
5.发明申请公开(公告)号：US20090202627A1
公开(公告)日：2009-08-13
申请号：US12424034
申请日：2009-04-15
申请人： Yves Claude NICOLAU
发明人： Yves Claude NICOLAU
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , A61K2039/55555 , C07K14/4711 , C07K14/4713 , C07K14/79 , C07K2319/00 , C12N2799/026
摘要： The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.
摘要翻译： 本发明一般涉及疾病状态的检测，治疗或预防。 具体地，本发明涉及淀粉样变性或淀粉样蛋白相关疾病的检测，治疗或预防。 本发明还包括包含治疗性疫苗，抗血清和分子构建体的方法和组合物，其包含其中编码的表达载体和融合蛋白。
-
-
-
-
搜索结果
5 条记录 (耗时 0.047 秒)
