公开(公告)号：US20230063291A1

公开(公告)日：2023-03-02

申请号：US17793937

申请日：2021-04-29

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  XINCHANG NHU VITAMINS COMPANY LTD.

发明人： Jiandong LI ,  Zhirong CHEN ,  Lifang SHI ,  Guodong HUANG ,  Lishuang PAN ,  Hong YIN ,  Dan QIU ,  Qilei ZHANG ,  Xiaoyong ZHU ,  Xiang LIU ,  Lidan QI

IPC分类号： A23K40/30 ,  A23K20/105 ,  A23K20/147 ,  A23K20/158 ,  A23K20/163

摘要： A stable carotenoid microcapsule having high bioavailability and a preparation method therefor. The method includes the following steps: a) mixing carotenoid crystals with an organic solvent, and dissolving the mixture to obtain a carotenoid solution; b) introducing the carotenoid solution and a grease into a dispersion system to fully disperse carotenoid into the grease, and vaporizing the organic solvent to obtain a carotenoid-containing dispersion liquid; c) mixing the carotenoid-containing dispersion liquid and a protective colloid aqueous solution, and emulsifying the mixture to obtain an emulsion; and d) performing spray granulation and drying to obtain a carotenoid microcapsule.

公开(公告)号：US20240016763A1

公开(公告)日：2024-01-18

申请号：US18256231

申请日：2022-03-24

申请人： ZHEJIANG NHU CO., LTD. ,  ZHEJIANG UNIVERSITY ,  XINCHANG NHU VITAMINS COMPANY LTD. ,  HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD.

发明人： Xiaoyong ZHU ,  Jiandong LI ,  Hongyue YAN ,  Zhirong CHEN ,  Jincheng CHENG ,  Qilei ZHANG ,  Wei LI ,  Tianqi LV ,  Guilai WANG

IPC分类号： A61K31/122 ,  A23L2/52 ,  A23L29/00 ,  A23L33/10 ,  A61K8/06 ,  A61K8/35 ,  A61K8/92 ,  A61K47/44 ,  A61K47/24 ,  A61Q19/00

CPC分类号： A61K31/122 ,  A23L2/52 ,  A23L29/06 ,  A23L33/10 ,  A61K8/068 ,  A61K8/355 ,  A61K8/922 ,  A61K47/44 ,  A61K47/24 ,  A61Q19/00 ,  A61K2800/10

摘要： Provided in the present invention are a coenzyme Q10 microemulsion, a preparation method therefor and the use thereof. The coenzyme Q10 microemulsion is prepared from components comprising coenzyme Q10, a carrier oil, an anti-crystallization agent, a lipophilic emulsifier, a hydrophilic emulsifier, a co-emulsifier and water. The microemulsion has a particle size DV(90) of between 20 nm and 80 nm, and is clear, transparent, free of demulsification and high in bioavailability, can be stably stored for a long time at normal temperatures and in extreme temperature environments. In addition, the microemulsion is suitable for the pharmaceutical, cosmetic and food fields, especially for beverages, oral liquids and other products. Also provided in the present invention is a method for preparing the coenzyme Q10 microemulsion, which is simple in equipment, low in cost and easy in operation.