公开(公告)号：US20200261493A1

公开(公告)日：2020-08-20

申请号：US16762147

申请日：2018-07-11

申请人： ZHEJIANG UNIVERSITY

发明人： Shiguo CHEN ,  Lufeng YAN ,  Danli WANG ,  Junhui LI ,  Xingqian YE ,  Donghong LIU

IPC分类号： A61K31/737 ,  A61P7/02 ,  A61P9/10

摘要： The present invention discloses a mixture of fucosylated chondroitin sulfate oligosaccharides having an average molecular weight between 2700 Da and 3600 Da, in which 90% of total components has a molecular weight between 1800 Da and 5400 Da. The mixture of fucosylated chondroitin sulfate oligosaccharide of the present invention has very low anti-FIIa factor activity, very low anti-FXa factor activity, very high anti-FXase factor activity, i.e., having a significant activity in selectively inhibiting intrinsic FXase, and a significant antithrombotic activity and no risk of bleeding and hypotension that are proved through animal experiments. The present invention also discloses a method for rapidly producing fucosylated chondroitin sulfate oligosaccharides by using sea cucumber as raw material, and the method includes: intercepting and concentrating crude polysaccharide with a membrane, deacetylation with hydrazine, pyrolysis with nitrous acid, reduction with sodium borohydride, membrane separation, etc., achieving rapid preparation and high yield.

公开(公告)号：US20240199826A1

公开(公告)日：2024-06-20

申请号：US17909285

申请日：2022-03-11

申请人： ZHEJIANG UNIVERSITY ,  JIANGNAN UNIVERSITY

发明人： Tian DING ,  Mofei SHEN ,  Donghong LIU ,  Wei ZHAO ,  Jinsong FENG

IPC分类号： C08J5/18 ,  C08K3/08 ,  C08K5/13

CPC分类号： C08J5/18 ,  C08K5/13 ,  C08J2383/04 ,  C08J2405/16 ,  C08K2003/0806 ,  C08K2201/011

摘要： A method for preparing a sustained release antibacterial film includes: (1) mixing a cyclodextrin metal-organic framework (CD-MOF) material with a silver nitrate short-chain alcohol solution to prepare an intermediate material A; (2) mixing the intermediate material A with a caffeic acid short-chain alcohol solution to prepare an intermediate material B; (3) dispersing the intermediate material B in a solvent, adding a polydimethylsiloxane main agent and a PDMS auxiliary agent in sequence, and mixing well by stirring to obtain a casting solution; and (4) coating the casting solution on a film support material, conducting vacuum drying, and peeling off a film from the film support material to obtain the sustained-release antibacterial film. A mixed matrix-based film material in which the CD-MOF and the PDMS are physically blended is prepared based on CD-MOF and PDMS for the first time, and may be used in application researches of food, environment and other fields.

公开(公告)号：US20240122178A1

公开(公告)日：2024-04-18

申请号：US18277559

申请日：2022-03-11

申请人： ZHEJIANG UNIVERSITY

发明人： Tian DING ,  Mofei SHEN ,  Jinsong FENG ,  Donghong LIU ,  Shiguo CHEN ,  Enbo XU ,  Wenjun WANG ,  Huan CHENG

IPC分类号： A01N37/38 ,  A01N25/10 ,  A01P1/00

CPC分类号： A01N37/38 ,  A01N25/10 ,  A01P1/00

摘要： Disclosed are a caffeic acid-based composite material and a preparation method thereof. The method includes: exposing a cyclodextrin metal-organic framework material prepared from γ-cyclodextrin to a solution of caffeic acid in a short-chain alcohol to obtain a mixed material; and incubating the mixed material, wherein during the incubating, the cyclodextrin metal-organic framework material is in dynamic contact with the solution of caffeic acid in a short-chain alcohol. The prepared composite material includes a cyclodextrin metal-organic framework material and caffeic acid loaded on the cyclodextrin metal-organic framework material, wherein the cyclodextrin metal-organic framework material is prepared from γ-cyclodextrin. The caffeic acid is loaded in an amount of 15-18% of a total mass of the caffeic acid-based composite material. The caffeic acid is located in a cavity of the cyclodextrin metal-organic framework material.

公开(公告)号：US20220227793A1

公开(公告)日：2022-07-21

申请号：US17617266

申请日：2020-06-11

申请人： ZHEJIANG UNIVERSITY

发明人： Tian DING ,  Dan WU ,  Mofei SHEN ,  Donghong LIU ,  Enbo XU

IPC分类号： C07F7/00 ,  C01B37/00 ,  C25B1/04 ,  C25B13/00 ,  C25B9/19

摘要： Disclosed are a zirconium-based metal-organic framework material and a preparation method thereof. Plasma-activated water or strong acid electrolyzed water is added to a raw material system for preparing a zirconium-based metal-organic framework material UiO-66, and they are then subjected to a reaction to obtain a crude product. The crude product is subjected to a post-treatment to obtain the zirconium-based metal-organic framework material UiO-66.

公开(公告)号：US20200283547A1

公开(公告)日：2020-09-10

申请号：US16648227

申请日：2017-09-26

申请人： ZHEJIANG UNIVERSITY

发明人： Shiguo CHEN ,  Hua ZHANG ,  Xingqian YE ,  Donghong LIU ,  Jiaqi ZHENG

IPC分类号： C08B37/00

摘要： The present disclosure discloses a method for extracting a RG-I-rich pectic polysaccharide. The method comprises the following steps: mixing and stirring a citrus fruit peel powder and a dilute hydrochloric acid solution at a low temperature to destroy cell walls of citrus peels, filtering, and then mixing the retentate with a sodium hydroxide solution for low temperature extraction, adding ethanol to the solution obtained by filtering to precipitate, and washing the obtained polysaccharide with ethanol and drying to obtain the above pectic polysaccharide. Compared with the traditional extraction method, this method reduces the hydrolysis of pectin side chains by controlling the extraction temperature, and the extracted pectic polysaccharide is rich in RG-I domain and has higher biological activity such as cancer and cardiovascular disease prevention. Energy can be greatly saved because of the low extraction temperature. The extracted pectic polysaccharide can be potentially used as functional food ingredients.

公开(公告)号：US20210113645A1

公开(公告)日：2021-04-22

申请号：US16754137

申请日：2018-09-27

申请人： ZHEJIANG UNIVERSITY

发明人： Shiguo CHEN ,  Jiaqi ZHENG ,  Xingqian YE ,  Donghong LIU ,  Hua ZHANG

IPC分类号： A61K36/752 ,  A23L33/105 ,  A23L33/135 ,  A23L33/00 ,  A61K9/08 ,  A61K9/14

摘要： The present disclosure discloses a method for preparing a citrus-derived complex prebiotic agent. The method comprises the following steps: removing external citrus peels after blanching citrus fruits with hot water, soaking citrus segments after splitting with an acid solution and an alkali solution to remove membranes of the citrus segments, and adjusting the pH of the obtained alkali soaking water with acid soaking water or acid to be weakly acidic or neutral to obtain the complex prebiotic agent, which has the function of reversing intestinal flora disorders. Compared with the traditional prebiotic product preparing method, the product prepared by the method contains prebiotic functional components with different targets such as pectin, flavonoids, oligosaccharides, and other fibers at the same time, and has the efficacies of regulating intestinal flora and reversing intestinal flora disorders caused by antibiotics. At the same time, the preparing method has the characteristics of simple operation and low cost, perfectly supplements a comprehensive utilization process of citrus fruit processing, solves the discharge problem of citrus fruit processing water, and generates very good social benefits.