公开(公告)号：US20230091250A1

公开(公告)日：2023-03-23

申请号：US17796613

申请日：2021-02-22

申请人： Zhuhai United Laboratories CO., LTD.

发明人： Weiwei MAO ,  Wenyuan QIAN ,  Changqing WEI ,  Liang FANG ,  Liwei MU ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  A61P29/00 ,  A61P19/02

摘要： The present invention discloses the crystal forms as a JAK inhibitor and their application in the preparation of drugs for the treatment of JAK1 or/and TYK2 related diseases.

公开(公告)号：US20230113620A1

公开(公告)日：2023-04-13

申请号：US17760233

申请日：2020-02-13

申请人： ZHUHAI UNITED LABORATORIES CO., LTD.

发明人： Shuai WANG ,  Degang WANG ,  Shouting WU ,  Tingting YU ,  Miao FANG ,  Liwei MU ,  Liang FANG

IPC分类号： A61K31/437 ,  A61K31/438 ,  A61P1/04 ,  A61P17/00 ,  A61P29/00

摘要： Disclosed is the use of a JAK inhibitor [1,2,4]-triazolo-[1,5-a]0pyridine compound in the preparation of drugs for treating autoimmune, inflammatory or allergic diseases, or diseases such as transplant rejection. The JAK inhibitor [1,2,4]-triazolo-[1,5-a]-pyridine compound comprises a compound as shown in formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof. The JAK inhibitor has a good efficacy in animal model tests of diseases such as autoimmune, inflammatory or allergic diseases.