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公开(公告)号：US20230113620A1
公开(公告)日：2023-04-13
申请号：US17760233
申请日：2020-02-13
发明人： Shuai WANG , Degang WANG , Shouting WU , Tingting YU , Miao FANG , Liwei MU , Liang FANG
IPC分类号： A61K31/437 , A61K31/438 , A61P1/04 , A61P17/00 , A61P29/00
摘要： Disclosed is the use of a JAK inhibitor [1,2,4]-triazolo-[1,5-a]0pyridine compound in the preparation of drugs for treating autoimmune, inflammatory or allergic diseases, or diseases such as transplant rejection. The JAK inhibitor [1,2,4]-triazolo-[1,5-a]-pyridine compound comprises a compound as shown in formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof. The JAK inhibitor has a good efficacy in animal model tests of diseases such as autoimmune, inflammatory or allergic diseases.
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公开(公告)号：US20240033255A1
公开(公告)日：2024-02-01
申请号：US18263434
申请日：2022-01-17
发明人： Zheng WANG , Peng GAO , Tingting YU , Yujun HE , Meiyue SHEN , Liwei MU , Jingjing LIU , Lixiu SHI , Degang WANG
IPC分类号： A61K31/437 , A61K9/20
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/2054 , A61K9/2027 , A61K9/2013 , A61K9/2059
摘要： An oral preparation, specifically including a JAK inhibitor and pharmaceutical excipients is provided, wherein the JAK inhibitor includes a compound of formula (I), an isomer thereof, pharmaceutically acceptable salts thereof, or their crystal form. The oral preparation of the present application has the characteristic of rapid dissolution. The oral preparation process of the present application is simple and suitable for large-scale industrial production.
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公开(公告)号：US20230091250A1
公开(公告)日：2023-03-23
申请号：US17796613
申请日：2021-02-22
发明人： Weiwei MAO , Wenyuan QIAN , Changqing WEI , Liang FANG , Liwei MU , Shuhui CHEN
IPC分类号： C07D471/04 , A61P29/00 , A61P19/02
摘要： The present invention discloses the crystal forms as a JAK inhibitor and their application in the preparation of drugs for the treatment of JAK1 or/and TYK2 related diseases.
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