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公开(公告)号：US20240033255A1
公开(公告)日：2024-02-01
申请号：US18263434
申请日：2022-01-17
发明人： Zheng WANG , Peng GAO , Tingting YU , Yujun HE , Meiyue SHEN , Liwei MU , Jingjing LIU , Lixiu SHI , Degang WANG
IPC分类号： A61K31/437 , A61K9/20
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/2054 , A61K9/2027 , A61K9/2013 , A61K9/2059
摘要： An oral preparation, specifically including a JAK inhibitor and pharmaceutical excipients is provided, wherein the JAK inhibitor includes a compound of formula (I), an isomer thereof, pharmaceutically acceptable salts thereof, or their crystal form. The oral preparation of the present application has the characteristic of rapid dissolution. The oral preparation process of the present application is simple and suitable for large-scale industrial production.
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公开(公告)号：US20230091250A1
公开(公告)日：2023-03-23
申请号：US17796613
申请日：2021-02-22
发明人： Weiwei MAO , Wenyuan QIAN , Changqing WEI , Liang FANG , Liwei MU , Shuhui CHEN
IPC分类号： C07D471/04 , A61P29/00 , A61P19/02
摘要： The present invention discloses the crystal forms as a JAK inhibitor and their application in the preparation of drugs for the treatment of JAK1 or/and TYK2 related diseases.
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公开(公告)号：US20230113620A1
公开(公告)日：2023-04-13
申请号：US17760233
申请日：2020-02-13
发明人： Shuai WANG , Degang WANG , Shouting WU , Tingting YU , Miao FANG , Liwei MU , Liang FANG
IPC分类号： A61K31/437 , A61K31/438 , A61P1/04 , A61P17/00 , A61P29/00
摘要： Disclosed is the use of a JAK inhibitor [1,2,4]-triazolo-[1,5-a]0pyridine compound in the preparation of drugs for treating autoimmune, inflammatory or allergic diseases, or diseases such as transplant rejection. The JAK inhibitor [1,2,4]-triazolo-[1,5-a]-pyridine compound comprises a compound as shown in formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof. The JAK inhibitor has a good efficacy in animal model tests of diseases such as autoimmune, inflammatory or allergic diseases.
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公开(公告)号：US11427581B2
公开(公告)日：2022-08-30
申请号：US16966112
申请日：2019-01-31
发明人： Weiwei Mao , Hao Wu , Xuejian Zheng , Guoping Hu , Changqing Wei , Jian Li , Shuhui Chen
IPC分类号： C07D471/04 , A61P19/02 , C07D513/04
摘要： Disclosed in the present application are a class of compounds as JAK inhibitors and use thereof in the preparation of medicaments for treating JAK and TYK2 related diseases. Specifically, a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof is disclosed.
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公开(公告)号：US20230365503A1
公开(公告)日：2023-11-16
申请号：US18245552
申请日：2021-09-28
发明人： Peng LI , Xiaolin LI , Zhi LUO , Haiying HE , Guoping HU , Jian LI , Shuhui CHEN
IPC分类号： C07D213/73
CPC分类号： C07D213/73 , C07B2200/13
摘要： A crystal form of a pyridinylphenyl compound and a preparation method therefor. Use of the crystal form in the preparation of a medicament of treating related diseases is also comprised.
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![[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof](/abs-image/US/2024/03/05/US11919896B2/abs.jpg.150x150.jpg)
公开(公告)号：US11919896B2
公开(公告)日：2024-03-05
申请号：US17263416
申请日：2019-08-23
发明人： Weiwei Mao , Wenyuan Qian , Xuejian Zheng , Guoping Hu , Changqing Wei , Jian Li , Shuhui Chen
IPC分类号： C07D471/04 , A61P19/02
CPC分类号： C07D471/04 , A61P19/02
摘要： Disclosed are a [1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and an application thereof in preparing a drug for treating a disease related to JAK1 or/and TYK2. Specifically, the present invention relates to a compound represented by formula (I), or an isomer or pharmaceutically acceptable salt thereof. (I)
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![[1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND USE THEREOF](/abs-image/US/2021/05/27/US20210155621A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210155621A1
公开(公告)日：2021-05-27
申请号：US17263416
申请日：2019-08-23
发明人： Weiwei MAO , Wenyuan QIAN , Xuejian ZHENG , Guoping HU , Changqing WEI , Jian LI , Shuhui CHEN
IPC分类号： C07D471/04 , A61P19/02
摘要： Disclosed are a [1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and an application thereof in preparing a drug for treating a disease related to JAK or/and TYK2. Specifically, the present invention relates to a compound represented by formula (I), or an isomer or pharmaceutically acceptable salt thereof. (I)
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公开(公告)号：US20240217949A1
公开(公告)日：2024-07-04
申请号：US18429297
申请日：2024-01-31
发明人： Peng LI , Xiaolin LI , Zhi LUO , Haiying HE , Guoping HU , Jian LI , Shuhui CHEN
IPC分类号： C07D401/12 , A61K31/4412 , A61K31/4418 , A61K31/444 , A61P27/04 , C07D213/73 , C07D401/04 , C07D401/06
CPC分类号： C07D401/12 , A61K31/4412 , A61K31/4418 , A61K31/444 , A61P27/04 , C07D213/73 , C07D401/04 , C07D401/06
摘要： Provided is an aldehyde binder, specifically, disclosed is a compound as represented by formula (II) or a pharmaceutically acceptable salt.
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公开(公告)号：US11932617B2
公开(公告)日：2024-03-19
申请号：US17309611
申请日：2019-12-18
发明人： Peng Li , Xiaolin Li , Zhi Luo , Haiying He , Guoping Hu , Jian Li , Shuhui Chen
IPC分类号： C07D401/04 , A61P27/02 , C07D213/73 , C07D401/06 , C07D401/12
CPC分类号： C07D401/04 , A61P27/02 , C07D213/73 , C07D401/06 , C07D401/12
摘要： Provided is an aldehyde binder, specifically, disclosed is a compound as represented by formula (II) or a pharmaceutically acceptable salt.
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公开(公告)号：US11753377B2
公开(公告)日：2023-09-12
申请号：US18000685
申请日：2021-06-17
发明人： Xiaolin Li , Chong Su , Zhi Luo , Fei Hao , Peng Li , Haiying He , Jian Li , Shuhui Chen
IPC分类号： C07D213/73 , A61P27/00
CPC分类号： C07D213/73 , A61P27/00 , C07B2200/13
摘要： A crystal form (such as formula I) of a 2-methyl-2-propanol and amino-substituted aryl compound and a preparation method therefor. Also provided is an application of the crystal form in the preparation of a medicine for treating related diseases.
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