公开(公告)号：US11977072B2

公开(公告)日：2024-05-07

申请号：US16479663

申请日：2018-01-30

申请人： ZOETIS SERVICES LLC

发明人： Rajesh K. Mehra ,  Kenneth P. Aron ,  Vincent Chiang ,  Sarah Ann Unser

IPC分类号： G01N33/543 ,  G01N21/53 ,  G01N21/552 ,  G01N33/553

CPC分类号： G01N33/54346 ,  G01N21/554 ,  G01N33/553 ,  G01N2469/10 ,  G01N2469/20

摘要： The present invention relates to nanostructure-binding partner conjugates, as well as reaction mixtures, analyte detection devices, and methods of making and using the conjugates. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample.