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公开(公告)号：US20230183258A1
公开(公告)日：2023-06-15
申请号：US18163680
申请日：2023-02-02
发明人： Raju MOHAN , John NUSS , Jason HARRIS , Shendong YUAN
IPC分类号： C07D491/18 , C07D513/18 , C07D471/18 , C07D495/18 , A61P29/00 , A61P25/28 , A61P3/10 , A61P9/10
CPC分类号： C07D491/18 , C07D513/18 , C07D471/18 , C07D495/18 , A61P29/00 , A61P25/28 , A61P3/10 , A61P9/10
摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
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公开(公告)号：US20210292336A1
公开(公告)日：2021-09-23
申请号：US17202047
申请日：2021-03-15
发明人： Raju MOHAN , John NUSS , Jason HARRIS , Shendong YUAN
IPC分类号： C07D491/18 , C07D495/18 , C07D471/18 , C07D513/18
摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
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公开(公告)号：US20220396559A1
公开(公告)日：2022-12-15
申请号：US17627082
申请日：2020-07-16
发明人： Raju MOHAN , John NUSS , Jason HARRIS , Shendong YUAN
IPC分类号： C07D307/82 , C07D307/935 , C07D491/048 , C07D495/04 , C07D333/62
摘要： Described herein are N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl) carbamoyl)-4,5,6,7-tetrahydrobenzofuran-2-sulfonamide derivatives and related compounds of formula (I) wherein R1 is formulae (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX) and R2 is formulae (X) or (XI) as NLPR3 (pyrin domain-containing protein 3) modulators for the treatment of e.g. metabolic diseases (e.g. type 2 diabetes or obesity), liver diseases (e.g. NAFLD or cirrhosis), lung diseases (e.g. asthma or CORD), central nervous system diseases (e.g. Alzheimer's disease or multiple sclerosis), inflammatory or autoimmune diseases (e.g. rheumatoid arthritis or psoriasis), cardiovascular diseases (e.g. atherosclerosis or stroke). The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 67 to 90; examples 1 to 21; compounds 1 to 126; tables). An exemplary compound is e.g. N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-hydroxy-4-methyl-4,5,6,7-tetrahydrobenzofuran-2-sulfonamide (Example 1; compound (5))
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公开(公告)号：US20240327413A1
公开(公告)日：2024-10-03
申请号：US18574530
申请日：2022-06-28
发明人： James COLLINS , Venkat BOLLU , Shendong YUAN , John NUSS
IPC分类号： C07D487/04 , A61K31/502 , A61K31/5025 , A61K31/53 , C07D401/12 , C07D495/04
CPC分类号： C07D487/04 , A61K31/502 , A61K31/5025 , A61K31/53 , C07D401/12 , C07D495/04
摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
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公开(公告)号：US20240101571A1
公开(公告)日：2024-03-28
申请号：US18483397
申请日：2023-10-09
发明人： Raju MOHAN , John NUSS , Jason HARRIS , Shendong YUAN
IPC分类号： C07D491/18 , C07D513/18 , C07D471/18 , C07D495/18 , A61P29/00 , A61P25/28 , A61P3/10 , A61P9/10
CPC分类号： C07D491/18 , C07D513/18 , C07D471/18 , C07D495/18 , A61P29/00 , A61P25/28 , A61P3/10 , A61P9/10
摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
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公开(公告)号：US20230295113A1
公开(公告)日：2023-09-21
申请号：US18183856
申请日：2023-03-14
发明人： James COLLINS , Venkat BOLLU , Shendong YUAN , John NUSS
IPC分类号： C07D401/08 , C07D471/08 , C07D403/08 , C07D471/04
CPC分类号： C07D401/08 , C07D471/08 , C07D403/08 , C07D471/04
摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
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公开(公告)号：US20220259170A1
公开(公告)日：2022-08-18
申请号：US17627084
申请日：2020-07-16
发明人： Raju MOHAN , John NUSS , Jason HARRIS , Shendong YUAN
IPC分类号： C07D307/93 , C07C311/60
摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
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