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    ENGINEERED IMMUNOGLOBULIN HEAVY CHAIN-LIGHT CHAIN PAIRS AND USES THEREOF
    2.
    发明申请
    ENGINEERED IMMUNOGLOBULIN HEAVY CHAIN-LIGHT CHAIN PAIRS AND USES THEREOF 审中-公开
    工程化免疫球蛋白重链链对及其用途

    公开(公告)号：US20150307594A1

    公开(公告)日：2015-10-29

    申请号：US14648222

    申请日：2013-11-28

    申请人： ZYMEWORKS INC.

    发明人： Adam Louis Corper ,  Dunja Urosev ,  Stacey A.L. Tom-Yew ,  Dustin Weyland Blue Bleile ,  Thomas Spreter Von Kreudenstein ,  Surjit Dixit ,  Paula Irene Lario

    IPC分类号： C07K16/00 ,  G06F19/24

    CPC分类号： C07K16/00 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/36 ,  C07K2317/10 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/72 ,  C07K2317/92 ,  C07K2317/94 ,  G06F19/24

    摘要： The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. At least one of the heterodimers can comprise one or more amino acid modifications in the C H and/or C L domains, one or more amino acid modifications in the V H and/or V L domains, or a combination thereof. The modified amino acid(s) can be part of the interface between the light chain and heavy chain and are typically modified to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer typically preferentially pairs with the second light chain rather than first.

    摘要翻译： 本发明提供了可以包含第一异二聚体和第二异二聚体的异二聚体对，其中每个异二聚体包含免疫球蛋白重链或其片段和免疫球蛋白轻链或其片段。 至少一个异源二聚体可以包含C H和/或C L结构域中的一个或多个氨基酸修饰，V H和/或V L结构域中的一个或多个氨基酸修饰或其组合。 修饰的氨基酸可以是轻链和重链之间的界面的一部分，并且通常被修饰以在每个重链和期望的轻链之间产生优先配对，使得当两条重链和两条轻链 异源二聚体对在细胞中共表达，第一异源二聚体的重链优先与轻链之一而不是另一个重合。 同样，第二异二聚体的重链通常优先与第二轻链配对，而不是首先。

    Engineered Immunoglobulin Heavy Chain-Light Chain Pairs and Uses Thereof
    5.
    发明申请
    Engineered Immunoglobulin Heavy Chain-Light Chain Pairs and Uses Thereof 有权

    公开(公告)号：US20210309760A1

    公开(公告)日：2021-10-07

    申请号：US17343198

    申请日：2021-06-09

    申请人： Zymeworks Inc.

    发明人： Adam Louis Corper ,  Dunja Urosev ,  Stacey A.L. Tom-Yew ,  Dustin Weyland Blue Bleile ,  Thomas Spreter Von Kreudenstein ,  Surjit Dixit ,  Paula Irene Lario ,  Mario Sanches

    IPC分类号： C07K16/36

    摘要： Provided are heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the CH1 and/or CL domains, amino acid modifications in the VH and/or VL domains or a combination thereof. The modified amino acid residues are part of the interface between the light chain and heavy chain and are modified in order to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a mammalian cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer preferentially pairs with the second light chain rather than first.

    Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
    6.
    发明授权
    Engineered immunoglobulin heavy chain-light chain pairs and uses thereof 有权

    公开(公告)号：US11078296B2

    公开(公告)日：2021-08-03

    申请号：US15896170

    申请日：2018-02-14

    申请人： Zymeworks Inc.

    发明人： Adam Louis Corper ,  Dunja Urosev ,  Stacey A. L. Tom-Yew ,  Dustin Weyland Blue Bleile ,  Thomas Spreter Von Kreudenstein ,  Surjit Dixit ,  Paula Irene Lario ,  Mario Sanches

    IPC分类号： C07K16/36 ,  C07K16/00

    摘要： Provided are heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the CH1 and/or CL domains, amino acid modifications in the VH and/or VL domains or a combination thereof. The modified amino acid residues are part of the interface between the light chain and heavy chain and are modified in order to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a mammalian cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer preferentially pairs with the second light chain rather than first.

    Engineered Immunoglobulin Heavy Chain-Light Chain Pairs And Uses Thereof
    8.
    发明申请
    Engineered Immunoglobulin Heavy Chain-Light Chain Pairs And Uses Thereof 有权
    工程免疫球蛋白重链轻链对及其用途

    公开(公告)号：US20140200331A1

    公开(公告)日：2014-07-17

    申请号：US14092804

    申请日：2013-11-27

    申请人： Zymeworks Inc.

    发明人： Adam Louis Corper ,  Dunja Urosev ,  Stacey A.L. Tom-Yew ,  Dustin Weyland Blue Bleile ,  Thomas Spreter Von Kreudenstein ,  Surjit Dixit ,  Paula Irene Lario

    IPC分类号： C07K16/28

    CPC分类号： C07K16/36 ,  C07K2317/55 ,  C07K2317/94

    摘要： The present invention provides heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the CH1 and/or CL domains, amino acid modifications in the VH and/or VL domains or a combination thereof. The modified amino acid residues are part of the interface between the light chain and heavy chain and are modified in order to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a mammalian cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer preferentially pairs with the second light chain rather than first.

    摘要翻译： 本发明提供包含第一异二聚体和第二异二聚体的异二聚体对，其中每个异二聚体包含免疫球蛋白重链或其片段和免疫球蛋白轻链。 至少一个异源二聚体包括CH1和/或CL结构域中的氨基酸修饰，VH和/或VL结构域中的氨基酸修饰或其组合。 修饰的氨基酸残基是轻链和重链之间的界面的一部分，并且被修饰以在每个重链和所需的轻链之间产生优先配对，使得当异源二聚体对的两条重链和两条轻链 在哺乳动物细胞中共表达，第一个异二聚体的重链优先与轻链之一而不是另一个重合。 同样，第二异源二聚体的重链优先与第二轻链配对，而不是首先。