公开(公告)号：US5364644A

公开(公告)日：1994-11-15

申请号：US12145

申请日：1993-01-28

申请人： Zbigniew Walaszek ,  Thomas J. Slaga ,  Margaret Hanausek

发明人： Zbigniew Walaszek ,  Thomas J. Slaga ,  Margaret Hanausek

IPC分类号： A61K31/045 ,  A23L1/03 ,  A23L1/30 ,  A23L1/302 ,  A23L1/304 ,  A23L1/305 ,  A61K31/07 ,  A61K31/12 ,  A61K31/19 ,  A61K31/194 ,  A61K31/215 ,  A61K31/28 ,  A61K31/30 ,  A61K31/355 ,  A61K31/375 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/455 ,  A61K31/505 ,  A61K31/51 ,  A61K31/714 ,  A61K33/00 ,  A61K33/42 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06 ,  A61P3/14

CPC分类号： A61K45/06 ,  A23L29/035 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K31/19 ,  A61K31/194 ,  A61K33/42 ,  A23V2002/00

摘要： The present invention provides a formula and method for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation. More specifically, the present invention provides a method for administering a formula including glucaric acid or a pharmaceutically acceptable salt thereof for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation in humans and animals. It has been determined that glucaric acid and pharmaceutically acceptable salts thereof significantly lower the total and LDL level of serum cholesterol and inhibit cellular hyperproliferation when administered in therapeutic amounts. It is intended that glucaric acid or a pharmaceutically acceptable salt thereof is employed alone or in combination with other medicinal agents for the prevention and treatment of hypercholesterolemia and cellular hyperproliferation.

摘要翻译： 本发明提供了预防和治疗高胆固醇血症和细胞过度增殖的方法和方法。 更具体地，本发明提供了一种给予包括葡糖二酸或其药学上可接受的盐的配方用于预防和治疗人和动物中的高胆固醇血症和细胞过度增殖的方法。 已经确定，当以治疗量施用时，葡糖二酸及其药学上可接受的盐显着降低血清胆固醇的总和LDL水平并抑制细胞过度增殖。 意图是葡糖二酸或其药学上可接受的盐单独使用或与其它药物组合使用以预防和治疗高胆固醇血症和细胞过度增殖。