公开(公告)号：US06491660B2

公开(公告)日：2002-12-10

申请号：US09768745

申请日：2001-01-23

申请人： Zihong Guo ,  Verivada Chandru Chandrasekaran ,  Tim J. Johnson ,  Brandon J. Shuman

发明人： Zihong Guo ,  Verivada Chandru Chandrasekaran ,  Tim J. Johnson ,  Brandon J. Shuman

IPC分类号： A61M100

CPC分类号： A61B17/320758 ,  A61B2017/22048 ,  A61B2017/22067 ,  A61B2017/320004 ,  A61M1/0058 ,  A61M1/0084

摘要： Infusion liquid is expelled distally of an ablation burr for washing a blood vessel lesion being treated by the burr. The infusion liquid can be aspirated in a proximate direction to carry the infusion liquid and loose ablated particles of the lesion away from the treatment area. The infusion liquid can be supplied through one or more passages in the burr, In addition to distally extending passages, the burr can include transverse passages extending at least partly in a proximate direction, with the distally extending and proximately extending passages sized so that only a minor portion of the infusion liquid is expelled distally.

摘要翻译： 输液被向远侧排出，用于清洗由毛刺所治疗的血管损伤的消融毛刺。 输液可以在近似的方向被吸入，以将输液液体和松散的病灶消融颗粒远离治疗区域。 输液可以通过毛刺中的一个或多个通道供应。除了远端延伸的通道之外，毛刺可以包括至少部分地在近似方向上延伸的横向通道，其中远端延伸和近似延伸的通道的尺寸使得只有 输液的少量部分向远侧排出。

公开(公告)号：US06800083B2

公开(公告)日：2004-10-05

申请号：US09829486

申请日：2001-04-09

申请人： Thomas J. Hiblar ,  Robert L. Barry ,  Edward Wulfman ,  Zihong Guo ,  Verivada Chandru Chandrasekaran

发明人： Thomas J. Hiblar ,  Robert L. Barry ,  Edward Wulfman ,  Zihong Guo ,  Verivada Chandru Chandrasekaran

IPC分类号： A61B1732

CPC分类号： A61B17/320758 ,  A61B17/320725 ,  A61B2017/320004

摘要： A rotational ablation atherectomy device including a flexible drive shaft and a compressible burr that may be inserted and extracted from a patient using a catheter having a diameter that is smaller than the operational diameter of the burr. In one embodiment, the burr includes a nose portion coupled to the drive shaft and one or more flexible abrasive disks disposed rearwardly from the nose portion. The flexible disks are foldable to be slidably received within a catheter. In another embodiment, the burr includes a support member coupled to the drive shaft, the support member having a resilient panel that spirals outwardly, forming a generally cylindrical ablation surface. The flexible panel can be elastically urged toward the support member and slidably inserted into the catheter. In a third embodiment, the burr includes a plurality of struts that are coupled to the drive shaft. An elastically compressible body disposed between the struts permits the struts to flex inwardly to reduce the burr diameter. In another embodiment, the burr includes a plurality of flexible wires attached at proximal and distal ends to the drive shaft. An abrasive sheath is disposed over the wires. The wires can be bent inwardly to compress the burr and re-expanded by rotation of the burr. In another embodiment, the burr comprises a nose portion and a resilient shell having a compressible, larger diameter abrasive section disposed at the proximal end of the nose portion.

摘要翻译： 包括柔性驱动轴和可压缩毛刺的旋转消融粥样斑块切除装置，其可以使用直径小于毛刺的操作直径的导管从患者插入和拔出。 在一个实施例中，毛刺包括联接到驱动轴的鼻部和从鼻部向后设置的一个或多个柔性研磨盘。 柔性盘可折叠成可滑动地容纳在导管内。 在另一个实施例中，毛刺包括联接到驱动轴的支撑构件，支撑构件具有向外螺旋的弹性面板，形成大致圆柱形的烧蚀表面。 柔性面板可以弹性地推向支撑构件并且可滑动地插入导管中。 在第三实施例中，毛刺包括联接到驱动轴的多个支柱。 设置在支柱之间的可弹性压缩体允许支柱向内弯曲以减小毛刺直径。 在另一个实施例中，毛刺包括在近端和远端附接到驱动轴的多个柔性线。 研磨护套设置在电线上。 电线可以向内弯曲以压缩毛刺并通过毛刺的旋转而重新膨胀。 在另一个实施例中，毛刺包括鼻部和弹性壳，弹性壳具有设置在鼻部的近端的可压缩的较大直径的研磨部。

公开(公告)号：US06554827B2

公开(公告)日：2003-04-29

申请号：US09735077

申请日：2000-12-11

申请人： Verivada Chandru Chandrasekaran ,  Zihong Guo ,  Brandon Shuman ,  Robert L. Barry

发明人： Verivada Chandru Chandrasekaran ,  Zihong Guo ,  Brandon Shuman ,  Robert L. Barry

IPC分类号： A61B1818

CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0041

摘要： An RF ablation system includes a catheter and an RF electrode that delivers RF electrical energy to the site of an occlusion. The system includes a mechanism for minimizing the likelihood that RF electrical energy will be applied directly to the vessel wall. In one embodiment of the invention, the catheter includes a number of tissue expanding jaws to engage a vessel wall and push the vessel wall away from the electrode to shield vessel walls from the electrode. In yet another embodiment of the invention, the electrode has a spiraled distal end with a radius that is larger than the radius of the catheter, such that the electrode engages the vessel wall and pushes the wall away from a conducting portion of the electrode. The portion of the electrode that engages the vessel wall is preferably coated with an insulating material to prevent delivery of RF electrical energy directly to the vessel wall.

公开(公告)号：US06569146B1

公开(公告)日：2003-05-27

申请号：US09642627

申请日：2000-08-18

申请人： Dennis Werner ,  David H. Dillard ,  Ray Fei ,  Gary Swinford ,  Verivada Chandru Chandrasekaran ,  Tim J. Johnson

发明人： Dennis Werner ,  David H. Dillard ,  Ray Fei ,  Gary Swinford ,  Verivada Chandru Chandrasekaran ,  Tim J. Johnson

IPC分类号： A61M3100

CPC分类号： A61B17/22 ,  A61B17/00491 ,  A61B2017/22038 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2017/22082 ,  A61B2017/320004

摘要： A method for treating loosely formed, friable or fragile lesions in a patient's blood vessel. A catheter having a pair of sealing mechanisms is advanced such that the sealing mechanisms are positioned distal to and proximal to the lesion. The sealing mechanisms are activated to seal the vessel on either side of the lesion. A medication is then delivered through the catheter to the sealed area of the vessel. The medication interacts with the lesion in order to partially or completely solidify it. Once the lesion is solidified, the catheter is removed and the lesion can be treated with a conventional intravascular device.

摘要翻译： 一种用于治疗患者血管中松散形成的，易碎的或易碎的病变的方法。 具有一对密封机构的导管被推进，使得密封机构位于病变的远侧和近侧。 激活密封机构以密封病变两侧的血管。 然后将药物通过导管输送到容器的密封区域。 药物与病变相互作用以部分或完全固化。 一旦病变固化，导管被移除，病变可用常规的血管内装置治疗。