公开(公告)号：US08314218B2

公开(公告)日：2012-11-20

申请号：US12604618

申请日：2009-10-23

申请人： Zita Mendes ,  António Carlos Silva Henriques ,  William Heggie

发明人： Zita Mendes ,  António Carlos Silva Henriques ,  William Heggie

IPC分类号： C07H17/00 ,  C07G3/00

CPC分类号： C07H17/08

摘要： The present invention relates to methods for synthesizing macrolide compounds which are known to have antibacterial activity, and are useful in the therapy of bacterial infections in mammals. More specifically, the invention relates to methods for synthesizing the macrolide antibiotic, gamithromycin utilizing a novel configuration of catalysts, chemical structures, and/or methods. An embodiment of the present invention may include allowing multiple chemical reactions to proceed without the isolation of chemical intermediates. Thus, multiple reactions may occur in one reaction vessel allowing for a considerable decrease in the cycle-time. The present invention also provides a novel method for inhibiting degradation while isolating a structure of a pharmaceutical composition.

摘要翻译： 本发明涉及已知具有抗菌活性的大环内酯类化合物的合成方法，并且可用于哺乳动物细菌感染的治疗。 更具体地说，本发明涉及利用催化剂的新型结构，化学结构和/或方法合成大环内酯类抗生素，吡咯霉素的方法。 本发明的一个实施方案可以包括允许多个化学反应进行而不隔离化学中间体。 因此，在一个反应​​容器中可能发生多次反应，允许循环时间显着降低。 本发明还提供了用于在分离药物组合物的结构的同时抑制降解的新方法。

公开(公告)号：US20100145035A1

公开(公告)日：2010-06-10

申请号：US12604618

申请日：2009-10-23

申请人： Zita Mendes ,  António Carlos Silva Henriques ,  William Heggie

发明人： Zita Mendes ,  António Carlos Silva Henriques ,  William Heggie

IPC分类号： C07H17/08

CPC分类号： C07H17/08

摘要： The present invention relates to methods for synthesizing macrolide compounds which are known to have antibacterial activity, and are useful in the therapy of bacterial infections in mammals. More specifically, the invention relates to methods for synthesizing the macrolide antibiotic, gamithromycin utilizing a novel configuration of catalysts, chemical structures, and/or methods. An embodiment of the present invention may include allowing multiple chemical reactions to proceed without the isolation of chemical intermediates. Thus, multiple reactions may occur in one reaction vessel allowing for a considerable decrease in the cycle-time. The present invention also provides a novel method for inhibiting degradation while isolating a structure of a pharmaceutical composition.

摘要翻译： 本发明涉及已知具有抗菌活性的大环内酯类化合物的合成方法，可用于哺乳动物细菌感染的治疗。 更具体地说，本发明涉及利用催化剂的新型结构，化学结构和/或方法合成大环内酯类抗生素，吡咯霉素的方法。 本发明的一个实施方案可以包括允许多个化学反应进行而不隔离化学中间体。 因此，在一个反应​​容器中可能发生多次反应，允许循环时间显着降低。 本发明还提供了用于在分离药物组合物的结构的同时抑制降解的新方法。