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公开(公告)号：US09340564B2
公开(公告)日：2016-05-17
申请号：US14731650
申请日：2015-06-05
申请人： Zoetis Services LLC
IPC分类号： C07D213/38 , A61K31/4418 , A61K31/675 , C07D213/40 , C07F9/58 , C07D401/06 , C07D239/26 , C07D277/28 , C07D333/20 , C07D413/06 , C07D241/12 , C07D417/06 , C07D271/06 , C07D285/12 , C07D401/04
CPC分类号： C07F9/58 , C07D213/16 , C07D213/38 , C07D213/40 , C07D239/26 , C07D241/12 , C07D271/06 , C07D277/28 , C07D285/12 , C07D333/20 , C07D401/04 , C07D401/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/10 , C07D491/107 , C07D495/10 , C07D513/04
摘要： The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
摘要翻译： 本发明提供了新型酚酞衍生物，其用于治疗哺乳动物感染的药物组合物，含有这些新化合物的药物组合物，以及制备这些化合物的方法。
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公开(公告)号：US20220211802A1
公开(公告)日：2022-07-07
申请号：US17696955
申请日：2022-03-17
申请人： Zoetis Services LLC
发明人： Michael P. Curtis , Susan M. Sheehan , Graham M. Kyne , Matthew W. Bedore , Richard A. Ewin , Paul D. Johnson , Tom L. McTier , Christopher S. Knauer , Rajendran Vairagoundar
IPC分类号： A61K38/15 , A61P33/00 , A61K31/35 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/7048 , C07K11/02
摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.
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公开(公告)号：US09073894B2
公开(公告)日：2015-07-07
申请号：US13785422
申请日：2013-03-05
申请人： Zoetis Services LLC
IPC分类号： C07D213/38 , C07F9/58 , A61K31/4418 , A61K31/661 , A61P31/00 , C07D401/06 , C07D213/40 , C07D239/26 , C07D277/28 , C07D333/20 , C07D413/06 , C07D241/12 , C07D417/06 , C07D271/06 , C07D285/12
CPC分类号： C07F9/58 , C07D213/16 , C07D213/38 , C07D213/40 , C07D239/26 , C07D241/12 , C07D271/06 , C07D277/28 , C07D285/12 , C07D333/20 , C07D401/04 , C07D401/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/10 , C07D491/107 , C07D495/10 , C07D513/04
摘要： The present invention provides novel phenicol derivatives of formula I their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
摘要翻译： 本发明提供式I的新型酚酞衍生物，其用于治疗哺乳动物感染的用途，含有这些新化合物的药物组合物，以及制备这些化合物的方法。
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公开(公告)号：US11786575B2
公开(公告)日：2023-10-17
申请号：US17696955
申请日：2022-03-17
申请人： Zoetis Services LLC
发明人： Michael P. Curtis , Susan M. Sheehan , Graham M. Kyne , Matthew W. Bedore , Richard A. Ewin , Paul D. Johnson , Tom L. McTier , Christopher S Knauer , Rajendran Vairagoundar
IPC分类号： A61K38/15 , A61P33/00 , C07K11/02 , A61K31/35 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/7048 , A61K38/00
CPC分类号： A61K38/15 , A61K31/35 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/7048 , A61P33/00 , C07K11/02 , A61K38/00
摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof
wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.-
公开(公告)号：US11331369B2
公开(公告)日：2022-05-17
申请号：US16652136
申请日：2018-11-28
申请人： Zoetis Services LLC
发明人： Michael P. Curtis , Susan M. Sheehan , Graham M. Kyne , Matthew W. Bedore , Richard A. Ewin , Paul D. Johnson , Tom L. McTier , Christoper S. Knauer , Rajendran Vairagoundar
IPC分类号： A61K38/15 , A61P33/00 , C07K11/02 , A61K31/35 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/7048 , A61K38/00
摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.
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公开(公告)号：US20200282016A1
公开(公告)日：2020-09-10
申请号：US16652136
申请日：2018-11-28
申请人： Zoetis Services LLC
发明人： Michael P. Curtis , Susan M. Sheehan , Graham M. Kyne , Matthew W. Bedore , Richard A. Ewin , Paul D. Johnson , Tom L. McTier , Christoper S. Knauer , Rajendran Vairagoundar
IPC分类号： A61K38/15 , C07K11/02 , A61P33/00 , A61K31/35 , A61K31/7048 , A61K31/506 , A61K31/4985 , A61K31/4188
摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.
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公开(公告)号：US20150266910A1
公开(公告)日：2015-09-24
申请号：US14731650
申请日：2015-06-05
申请人： Zoetis Services LLC
发明人： Michael Curtis , Brian A. Duclos , Richard A. Ewin , Paul D. Johnson , Timothy Allan Johnson , Rajendran Vairagoundar , Denis Billen , Richard M. Goodwin , Andrea K. Haber-Stuk , Graham M. Kyne , Susan M. K. Sheehan
IPC分类号： C07F9/58 , C07D333/20 , C07D277/28 , C07D239/26 , C07D401/06 , C07D271/06 , C07D401/04 , C07D213/38 , C07D285/12
CPC分类号： C07F9/58 , C07D213/16 , C07D213/38 , C07D213/40 , C07D239/26 , C07D241/12 , C07D271/06 , C07D277/28 , C07D285/12 , C07D333/20 , C07D401/04 , C07D401/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/10 , C07D491/107 , C07D495/10 , C07D513/04
摘要： The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
摘要翻译： 本发明提供了新型酚酞衍生物，其用于治疗哺乳动物感染的药物组合物，含有这些新化合物的药物组合物，以及制备这些化合物的方法。
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公开(公告)号：US11771738B2
公开(公告)日：2023-10-03
申请号：US17052571
申请日：2019-05-07
申请人： Zoetis Services LLC
发明人： Todd Maddux , Matthew W. Bedore , Paul D. Johnson , Tomasz Respondek , Susan M. K. Sheehan , Graham M. Kyne , Richard A. Ewin , Rajendran Vairagoundar , Michael P. Curtis
IPC分类号： A61K38/15 , A61P33/00 , C07D273/00 , C07D413/10 , C07D413/14 , C07D417/14
CPC分类号： A61K38/15 , A61P33/00 , C07D273/00 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof
wherein each of R1, R2, R3, R4, L1, and L2 are as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.-
公开(公告)号：US20230071039A1
公开(公告)日：2023-03-09
申请号：US17870885
申请日：2022-07-22
申请人： Zoetis Services LLC
IPC分类号： C07D451/04 , C07D519/00
摘要： The invention describes novel serotonin c5-HT2B receptor antagonists of Formula (1), and pharmaceutically acceptable salts thereof; wherein Ring A, L, X, X′, R3, R4, m and n are as defined herein. Also described are compositions comprising a Formula (1) compound, or a pharmaceutically acceptable salt thereof; and methods of using the compounds, or a pharmaceutically acceptable salt thereof, for the treatment of myxomatous mitral valve disease (MMVD), congestive heart failure (CHF) and/or asymptomatic heart failure in animals, preferably is a canine.
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公开(公告)号：US20220323540A1
公开(公告)日：2022-10-13
申请号：US17052571
申请日：2019-05-07
申请人： Zoetis Services LLC
发明人： Todd Maddux , Matthew W. Bedore , Paul D. Johnson , Tomasz Respondek , Susan M.K. Sheehan , Graham M. Kyne , Richard A. Ewin , Rajendran Vairagoundar , Michael P. Curtis
IPC分类号： A61K38/15 , A61P33/00 , C07D273/00 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R1, R2, R3, R4, L1, and L2 are as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.
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