公开(公告)号：US12031907B2

公开(公告)日：2024-07-09

申请号：US16847236

申请日：2020-04-13

申请人： betaSENSE GmbH

发明人： Klaus Gerwert ,  Jens Wiltfang ,  Julian Ollesch ,  Andreas Nabers ,  Jonas Schartner ,  Carsten Kötting

IPC分类号： G01N21/3577 ,  G01N21/552 ,  G01N21/64 ,  G01N33/68 ,  G01N21/05

CPC分类号： G01N21/3577 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/6896 ,  G01N21/05 ,  G01N2021/6421 ,  G01N2800/2821 ,  G01N2800/2835

摘要： Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.

公开(公告)号：US11592451B2

公开(公告)日：2023-02-28

申请号：US16349194

申请日：2017-11-21

申请人： betaSENSE GmbH

发明人： Klaus Gerwert ,  Andreas Nabers ,  Jonas Schartner

IPC分类号： G01N33/68 ,  G01N21/552 ,  G01N21/35

摘要： The invention provides a method that gives direct information about the intervention of a potential drug on the secondary structure distribution of a targetbiomolecule, i.e., for a disease with misfolded protein, such as neurodegenerative diseases in a complex body fluid. The secondary structural change is monitored by vibrational spectroscopy. The method can be applied for prescreening of drug candidates for targeting of specific biomolecules. The effect of the drug on the secondary structure distribution is monitored label-free in real time and provides thereby direct information about the efficacy of the potential drug.