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    Fluorogenic/Fluorescent Probes Derivative from Sulfoxanthene, and Use Thereof
    2.
    发明申请
    Fluorogenic/Fluorescent Probes Derivative from Sulfoxanthene, and Use Thereof 有权
    由亚砜衍生的荧光荧光探针及其用途

    公开(公告)号：US20160146814A1

    公开(公告)日：2016-05-26

    申请号：US14720017

    申请日：2015-05-22

    申请人： bioMérieux ,  Centre National de la Recherche Scientifique ,  Université de Rouen

    发明人： Sylvain Orenga ,  Valérie Chalansonnet ,  Arnaud Chevalier ,  Pierre-Yves Renard ,  Anthony Romieu ,  Benoît Roubinet

    IPC分类号： G01N33/573 ,  G01N33/58 ,  G01N33/542 ,  C09B49/12

    CPC分类号： G01N33/573 ,  C09B11/24 ,  C09B49/126 ,  C12Q1/26 ,  C12Q1/34 ,  G01N33/542 ,  G01N33/581 ,  G01N2333/902 ,  G01N2333/90688 ,  G01N2333/908 ,  G01N2333/916 ,  G01N2333/918 ,  G01N2333/948

    摘要： The invention relates to fluorescent/fluorogenic probes of formula (I″) or (II″): wherein Z is chosen between: —NH2 and —OH, or in the fluorescence quencher group consisting of: —NO2; —N═N—R1; R1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R2; —O—P(O)(OR2)(OR2′) and —O—S(O)2—R2; R2 and R2′ being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and Ra, Rb, Rc, Rd and Re being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity. It also relates to the use of these fluorescent/fluorogenic probes, for the detection of an enzyme activity, notably in order to identify/discriminate microorganisms in function of their ability to express particular enzyme activities.

    摘要翻译： 本发明涉及式（I“）或（II”）的荧光/荧光探针：其中Z选自：-NH 2和-OH，或在由以下组成的荧光猝灭剂组中：-NO 2; -N = N-R1; R1是不掩盖相应偶氮键的任何有机基团; -NHCO-肽; Pept。 是肽残基或不掩盖相应酰胺键的任何有机基团; -O-Glyc; 糖 是不会使相应的糖苷键模糊的寡糖苷残基; -O-C（O）-R2; -O-P（O）（OR 2）（OR 2'）和-O-S（O）2 -R 2; R2和R2'独立地是氢原子或不掩盖相应的酯键的有机基团; 并且Ra，Rb，Rc，Rd和Re独立地是氢原子或任何不掩盖相应的芳基醚键的有机基团，以便不会通过髓过氧化物酶活性阻止其可能的切割。 它还涉及这些荧光/荧光探针用于检测酶活性的用途，特别是为了鉴别/鉴别微生物，以表达特定酶活性的能力。