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公开(公告)号：US20240328910A1
公开(公告)日：2024-10-03
申请号：US18622914
申请日：2024-03-30
发明人： James Grille , Brian D. Kelly , Jerome Kosmeder, II , Eric May , Noemi Sebastiao , Pamela Wirth
IPC分类号： G01N1/30 , A61K49/00 , C01B15/01 , C01B21/08 , C07C55/02 , C07C55/22 , C07C55/24 , C12N9/99 , G01N33/52
CPC分类号： G01N1/30 , C01B15/01 , C01B21/08 , C07C55/02 , C07C55/22 , C07C55/24 , C12N9/99 , G01N33/52 , A61K49/001 , G01N2001/302 , G01N2333/902 , G01N2333/908 , G01N2333/916
摘要： Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.
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公开(公告)号：US12024730B1
公开(公告)日：2024-07-02
申请号：US18516940
申请日：2023-11-21
发明人： Qinbin Sun
CPC分类号： C12N9/98 , C12N9/0006 , C12N9/0065 , C12Q1/54 , C12Y101/03004 , C12Q2326/50 , C12Q2326/96 , G01N2333/904 , G01N2333/908
摘要： A granule for detecting glucose in pet urine, includes: 80-100 parts by weight of a filler, 30-50 parts by weight of water-absorbent material, 2-4 parts by weight of a bacteriostatic agent, 5-10 parts by weight of an adhesive, 1-2 parts by weight of glucose oxidase, 2-4 parts by weight of peroxidase, 2-6 parts by weight of an indicator.
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公开(公告)号：US12004858B2
公开(公告)日：2024-06-11
申请号：US17151274
申请日：2021-01-18
发明人： Stephen Oja , Tianmei Ouyang , Hyun Cho , Lam N. Tran , Benjamin J. Feldman , Ashwin Kumar , Namvar Kiaie
IPC分类号： A61B5/1486 , A61B5/145 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/002 , C12Q1/005 , G01N2333/9029 , G01N2333/904 , G01N2333/908
摘要： Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
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4.发明公开公开(公告)号：US20240183863A1
公开(公告)日：2024-06-06
申请号：US18410121
申请日：2024-01-11
发明人： Viviana P. Ferreira
IPC分类号： G01N33/68 , G01N1/40 , G01N33/543
CPC分类号： G01N33/6893 , G01N1/4077 , G01N33/54386 , G01N33/6854 , G01N2001/4088 , G01N2333/4716 , G01N2333/908
摘要： Methods measuring properdin function and kits for conducting ELISA assays using anti-properdin antibodies and uses thereof are described.
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公开(公告)号：US20230384295A1
公开(公告)日：2023-11-30
申请号：US18234057
申请日：2023-08-15
申请人： Ultivue, Inc.
发明人： Mark Bobrow , Stephanie Rae Hennek , Mael Manesse
IPC分类号： G01N33/535 , G01N33/542 , G01N33/543 , G01N33/58 , C12Q1/6804
CPC分类号： G01N33/535 , G01N33/542 , G01N33/54306 , C12Q2563/125 , C12Q1/6804 , G01N2333/908 , C12Q2537/143 , G01N33/581
摘要： A method for testing a sample for the presence of one or more targets comprises multiplexed catalyzed reporter deposition (CARD) is provided.
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公开(公告)号：US20230221323A1
公开(公告)日：2023-07-13
申请号：US17984197
申请日：2022-11-09
发明人： Elena MARTINEZ GARCÍA , Eva COLÁS ORTEGA , Antonio GIL MORENO , Jaume REVENTÓS PUIGJANER , Bruno DOMON , Antoine LESUR
IPC分类号： G01N33/574
CPC分类号： G01N33/57442 , G01N2800/52 , G01N2333/908 , G01N2333/96494
摘要： The present invention provides a method of diagnosis or prognosis endometrial carcinoma, the method comprising determining the level of expression of MMP9 in a uterine aspirate fluid sample from the female genital tract. The present invention further provides kits for the diagnosis of the disease.
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公开(公告)号：US20230213525A1
公开(公告)日：2023-07-06
申请号：US16090091
申请日：2017-03-30
申请人： QUALIZYME DIAGNOSTICS GMBH & CO KG , UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, VIENNA , ACIB GMBH
发明人： Michael BURNET , Andrea HEINZLE , Eva SIGL , Daniel LUSCHNIG , Clemens GAMERITH , Gregor TEGL , Georg GUEBITZ
IPC分类号： G01N33/58 , G01N33/573 , G01N33/548
CPC分类号： G01N33/583 , G01N33/548 , G01N33/573 , G01N2333/902 , G01N2333/908 , G01N2333/916 , G01N2333/936 , G01N2333/966 , G01N2400/40 , G01N2800/26
摘要： The disclosed technology relates to chemical entities for the detection of wounds, e.g., chronic wounds or infected wounds, including compositions, substrates, kits, dressing materials, and articles, and systems containing such compounds. The disclosed technology further relates to methods of using these compositions, kits and systems in diagnostic assays, and in the diagnosis and/or detection of chronic or infected wounds based on enzymatic action on specific moieties and/or reaction sites. Additional disclosure relates to methods of characterizing wounds based on expression of a plurality of markers and using such information to treat, manage, and follow-up patients suffering from chronic or infected wounds.
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公开(公告)号：US20190049468A9
公开(公告)日：2019-02-14
申请号：US15261674
申请日：2016-09-09
发明人： Shouji Ochiai , Takeyuki Moriuchi , Masao Takinami
CPC分类号： G01N33/721 , C12Q1/54 , C12Y101/03004 , C12Y111/01 , G01N21/27 , G01N21/274 , G01N21/31 , G01N21/35 , G01N21/78 , G01N21/783 , G01N21/8483 , G01N33/66 , G01N2201/061 , G01N2201/12 , G01N2333/805 , G01N2333/904 , G01N2333/908
摘要： Provided is a component measuring apparatus configured to determine a functional form that describes wavelength characteristics of a variation attributable to scattering (S (λ)). The apparatus then determines unknown one or more coefficients (p, q) based on a first relational expression that involves a variation attributable to absorption (H (λ1)) and a group of second relational expressions that do not involve variations attributable to absorption (H (λ2a), H (λ2b), H (λ2c)). The apparatus then corrects an absorbance measured at an arbitrary wavelength (λ) using a function where the one or more coefficients (p, q) are applied to the functional form so as to reduce or eliminate at least the effects of scattering of light.
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公开(公告)号：US20180095084A1
公开(公告)日：2018-04-05
申请号：US15725835
申请日：2017-10-05
发明人： Zhengliang L. Wu , Xinyi Huang , Cheryl M. Ethen
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , C12Q1/34 , C12Q1/48 , C12Y111/01007 , C12Y204/01 , C12Y302/01166 , G01N33/582 , G01N2333/908 , G01N2333/91091 , G01N2333/91097 , G01N2333/924
摘要： A method for assaying endoglycosidase activity includes providing a proteoglycan having a glycosaminoglycan chain with a non-reducing end; treating the proteoglycan with a glycosyltransferase to incorporate a carbohydrate into the non-reducing end of the glycosaminoglycan chain, wherein the carbohydrate includes a click chemistry moiety; adding a label to the proteoglycan, wherein the label includes a click chemistry moiety that reacts to the click chemistry moiety of the carbohydrate such that the label attaches to the carbohydrate to form a labeled proteoglycan; immobilizing the labeled proteoglycan on a multi-well plate, wherein the multi-well plate includes a specific anti-proteoglycan antibody for binding the labeled proteoglycan; treating the labeled proteoglycan with an endoglycosidase specific to the glycosaminoglycan chain; and detecting the labeled proteoglycan.
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公开(公告)号：US09903871B2
公开(公告)日：2018-02-27
申请号：US14800162
申请日：2015-07-15
IPC分类号： G01N33/574 , G01N33/563 , G01N33/577 , C07K16/40
CPC分类号： G01N33/57488 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/76 , G01N2333/902 , G01N2333/908 , G01N2800/52
摘要： An embodiment of the invention relates to the use of stabilized cancer peptide fragments derived from “redoxin proteins” selected from the group consisting of thioredoxin; peroxiredoxin-1, 2 and 3; glutaredoxin-3; glutathione peroxidase-4; and nucleoredoxins for the diagnosis of cancers, particularly pancreatic cancer. A method for the detection of cancer, severity of cancer, and/or effectiveness of a therapeutic regimen comprises detecting and/or measuring the amount of redoxin peptide fragments present in the biological sample of a subject.
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