公开(公告)号：US10968248B2

公开(公告)日：2021-04-06

申请号：US16600336

申请日：2019-10-11

Applicant: c/o Arcturus Therapeutics, Inc.

Inventor： Padmanabh Chivukula ,  Steven P. Tanis ,  Joseph E. Payne

IPC: C07H21/00 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07H21/02 ,  A61K31/7125

Abstract: What is described is a trinucleotide cap analog comprising m7G(5′)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5′)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5′)p3 is a 5′,5′-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.