公开(公告)号：US20030049598A1

公开(公告)日：2003-03-13

申请号：US09947954

申请日：2001-09-06

申请人： deCODE genetics ehf

发明人： Hakon Hakonarson ,  Michael M. Grunstein

IPC分类号： C12Q001/00 ,  C12Q001/68 ,  C12N005/06

CPC分类号： G01N33/6863 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6869 ,  G01N2333/525 ,  G01N2333/545 ,  G01N2500/10 ,  G01N2800/52

摘要： The present invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1null, TNFnull or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.

摘要翻译： 本发明涉及在常驻组织细胞中诱导前哮喘/促炎症状状态的方法，包括使细胞与IL-1β，TNFα或两者接触。 还公开了用于鉴定调节对抗炎药物的反应的基因，药物筛选方法以及用于鉴定与各种前哮喘/促炎症疾病表型相关的基因的方法的方法。