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1.发明授权公开(公告)号：US09433653B2
公开(公告)日：2016-09-06
申请号：US14706325
申请日：2015-05-07
发明人： Seong Jun Yoon , Soo Youn Jun , Hyoung Rok Paik , Jee Soo Son , Hye In Jeong , Sang Hyeon Kang
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/00021 , C12N2795/00031 , C12N2795/00032 , C12N2795/10121 , C12N2795/10131 , C12N2795/10132 , C12N2795/10171 , Y02A50/473
摘要： The present invention relates to a composition comprising the bacteriophage EK88P-1 isolated from the nature and having a broad antibacterial spectrum against E. coli as an active ingredient, and a method for preventing and treating E. coli infections using the said composition. The bacteriophage EK88P-1, the active ingredient of the composition of the present invention, has a broad antibacterial spectrum against E. coli and has the genome characteristically composed of the partial nucleotide sequences represented by SEQ ID NO: 1 to SEQ ID NO: 25, and also characterized by the bacteriophage belonging to the Myoviridae family according to the morphology that is composed of the major structural proteins in the sizes of approximately 49 kDa, 53 kDa, 94 kDa, and 103 kDa.
摘要翻译： 本发明涉及一种组合物，其包含从性质中分离的噬菌体EK88P-1，并具有对大肠杆菌作为活性成分的广谱抗菌谱，以及使用所述组合物预防和治疗大肠杆菌感染的方法。 噬菌体EK88P-1是本发明组合物的活性成分，对大肠杆菌具有广泛的抗菌谱，其特征在于由SEQ ID NO：1至SEQ ID NO：25表示的部分核苷酸序列组成的基因组 ，并且其特征还在于根据由约49kDa，53kDa，94kDa和103kDa的大小的主要结构蛋白质组成的形态的属于病毒科的噬菌体。
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公开(公告)号：US11596659B2
公开(公告)日：2023-03-07
申请号：US15930394
申请日：2020-05-12
发明人： Seong Jun Yoon , Jee Soo Son , In Hwang Kim , Hyoung Rok Paik , Hyun Joo Im , Hyun Jin Yu , Cheol Ahn , Tae Yeol Kim , Soo Youn Jun , Sang Hyeon Kang
摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Myoviridae bacteriophage Esc-COP-18 having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Myoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Myoviridae bacteriophage.
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公开(公告)号：US11583565B2
公开(公告)日：2023-02-21
申请号：US16840334
申请日：2020-04-04
发明人： Seong Jun Yoon , Jee Soo Son , In Hwang Kim , Hyoung Rok Paik , Hyun Joo Im , Ji Young Park , Hyun Jin Yu , Ji Yeong Seo , Soo Youn Jun , Sang Hyeon Kang
摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Myoviridae bacteriophage having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Myoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Myoviridae bacteriophage.
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4.发明申请METHOD FOR PREVENTION AND TREATMENT OF ESCHERICHIA COLI INFECTIONS USING A BACTERIOPHAGE WITH BROAD ANTIBACTERIAL SPECTRUM AGAINST ESCHERICHIA COLI 有权使用细菌与广谱抗体谱对抗病原菌感染的ESCHERICHIA COLI感染的预防和治疗方法公开(公告)号：US20150322409A1
公开(公告)日：2015-11-12
申请号：US14706325
申请日：2015-05-07
发明人： Seong Jun YOON , Soo Youn Jun , Hyoung Rok Paik , Jee Soo Son , Hye In Jeong , Sang Hyeon Kang
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/00021 , C12N2795/00031 , C12N2795/00032 , C12N2795/10121 , C12N2795/10131 , C12N2795/10132 , C12N2795/10171 , Y02A50/473
摘要： The present invention relates to a composition comprising the bacteriophage EK88P-1 isolated from the nature and having a broad antibacterial spectrum against E. coli as an active ingredient, and a method for preventing and treating E. coli infections using the said composition. The bacteriophage EK88P-1, the active ingredient of the composition of the present invention, has a broad antibacterial spectrum against E. coli and has the genome characteristically composed of the partial nucleotide sequences represented by SEQ. ID. NO: 1˜NO: 25, and also characterized by the bacteriophage belonging to the Myoviridae family according to the morphology that is composed of the major structural proteins in the sizes of approximately 49 kDa, 53 kDa, 94 kDa, and 103 kDa.
摘要翻译： 本发明涉及一种组合物，其包含从性质中分离的噬菌体EK88P-1，并具有对大肠杆菌作为活性成分的广谱抗菌谱，以及使用所述组合物预防和治疗大肠杆菌感染的方法。 噬菌体EK88P-1是本发明组合物的活性成分，具有抗大肠杆菌的广谱抗菌谱，其特征在于由SEQ ID NO：1所示的部分核苷酸序列组成的基因组。 ID。 NO：1〜NO：25，其特征还在于根据由约49kDa，53kDa，94kDa和103kDa大小的主要结构蛋白质组成的形态，属于病毒科的噬菌体。
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公开(公告)号：US11701398B2
公开(公告)日：2023-07-18
申请号：US16893106
申请日：2020-06-04
发明人： Seong Jun Yoon , Jee Soo Son , In Hwang Kim , Hyoung Rok Paik , Hyun Joo Im , Hyun Jin Yu , Beom Seok Kim , Geun Woo Lee , Soo Youn Jun , Sang Hyeon Kang
摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Podoviridae bacteriophage (Esc-COP-30) having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Podoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Podoviridae bacteriophage.
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6.发明申请公开(公告)号：US20210283202A1
公开(公告)日：2021-09-16
申请号：US17258722
申请日：2019-06-07
发明人： Seong Jun Yoon , Soo Youn Jun , Jee Soo Son , Hyoung Rok Paik , Hyun Joo Lee , Sang Hyeon Kang
IPC分类号： A61K35/76 , A23L3/3571 , A23K10/16 , C12N7/00
摘要： The present invention relates to a Myoviridae bacteriophage Esc-COP-14 (Accession number: KCTC 13528BP) isolated from nature, and characterized by having the ability to specifically kill Escherichia coli and having the genome represented by SEQ. ID. NO: 1, and to a method for preventing and treating the infection of pathogenic Escherichia coli using the composition comprising Myoviridae bacteriophage Esc-COP-14 as an active ingredient.
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