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公开(公告)号：US11596659B2
公开(公告)日：2023-03-07
申请号：US15930394
申请日：2020-05-12
发明人： Seong Jun Yoon , Jee Soo Son , In Hwang Kim , Hyoung Rok Paik , Hyun Joo Im , Hyun Jin Yu , Cheol Ahn , Tae Yeol Kim , Soo Youn Jun , Sang Hyeon Kang
摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Myoviridae bacteriophage Esc-COP-18 having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Myoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Myoviridae bacteriophage.
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公开(公告)号：US11583565B2
公开(公告)日：2023-02-21
申请号：US16840334
申请日：2020-04-04
发明人： Seong Jun Yoon , Jee Soo Son , In Hwang Kim , Hyoung Rok Paik , Hyun Joo Im , Ji Young Park , Hyun Jin Yu , Ji Yeong Seo , Soo Youn Jun , Sang Hyeon Kang
摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Myoviridae bacteriophage having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Myoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Myoviridae bacteriophage.
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3.发明授权公开(公告)号：US11492378B2
公开(公告)日：2022-11-08
申请号：US17100232
申请日：2020-11-20
发明人： Seong Jun Yoon , Myung Soo Kang , Soo Youn Jun , Jong Hyun Kim , Gi Mo Jung , Jee Soo Son , Hyoun Rok Paik , Sang Hyeon Kang
IPC分类号： C07K14/005 , A61P31/04 , C12N15/70 , A61K38/00
摘要： The present invention relates to an antibacterial protein EFAL-2 derived from bacteriophage Ent-FAP-4 (Accession number: KCTC 12854BP), which has the ability to kill Enterococcus faecium and an amino acid sequence represented by SEQ ID NO: 2, a pharmaceutical composition containing the same as an active ingredient, and a method for preventing or treating diseases caused by Enterococcus faecium using the pharmaceutical composition.
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公开(公告)号：US20210054345A1
公开(公告)日：2021-02-25
申请号：US17043847
申请日：2019-02-19
发明人： Seong Jun Yoon , Soo Youn Jun , Jee Soo Son , Hyoun Rok Paik , Beom Seok Kim , Sang Hyeon Kang
摘要： The present invention relates to a Siphoviridae bacteriophage STP-2 (Accession number: KCTC 12853BP) isolated from nature and characterized by having the ability to destroy Salmonella Typhimurium and having a genome represented by SEQ ID NO:1; and to a method for preventing and treating diseases caused by Salmonella Typhimurium using Siphoviridae bacteriophage STP-2 containing the same as an active ingredient.
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公开(公告)号：US10696989B2
公开(公告)日：2020-06-30
申请号：US16475409
申请日：2017-12-06
发明人： Seong Jun Yoon , Jung In Pyo , Soon Hye Hwang , Soo Youn Jun , Sang Hyeon Kang
IPC分类号： C12P9/00 , C07D487/22
摘要： The present invention relates to heme iron not derived from porcine blood and a method of preparing the same, and more particularly to a method of biologically preparing heme iron not derived from porcine blood, a method of preparing a salt thereof, and an iron supplement containing the salt thus prepared as an active ingredient.
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公开(公告)号：US10568917B2
公开(公告)日：2020-02-25
申请号：US16064747
申请日：2016-11-10
发明人： Seong Jun Yoon , Soo Youn Jun , Hyoun Rok Paik , Jee Soo Son , Dong Min Kang , Sang Hyeon Kang
IPC分类号： A61K39/102 , A61K35/76 , A61K8/99 , A23K20/195 , C12N7/00 , A61Q17/00 , A23K10/18 , A23K50/30 , A23K50/60 , A61Q19/10 , A23K20/10 , A61P31/04
摘要： The present invention relates to: Myoviridae bacteriophage Pas-MUP-1 (accession number KCTC 12706BP) which has the capability to specifically destroy Pasteurella multocida, is characterized by having a genome represented by SEQ ID NO: 1, and is isolated from nature; and a method for preventing and treating Pasteurella multocida infections, using a composition containing bacteriophage Pas-MUP-1 as an active ingredient.
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7.发明申请公开(公告)号：US20200055902A1
公开(公告)日：2020-02-20
申请号：US16487508
申请日：2018-01-11
发明人： Seong Jun Yoon , Myung Soo Kang , Soo Youn Jun , Jong Hyun Kim , Gi Mo Jung , Jee Soo Son , Hyoun Rok Paik , Sang Hyeon Kang
IPC分类号： C07K14/005 , A61P31/04 , C12N15/70
摘要： The present invention relates to an antibacterial protein EFAL-2 derived from bacteriophage Ent-FAP-4 (deposition number KCTC 12854BP), a pharmaceutical composition including the same as an active ingredient, and a method for preventing or treating diseases caused by Enterococcus faecium by using the pharmaceutical composition, the antibacterial protein EFAL-2 being characterized by having the ability capable of killing Enterococcus faecium and having an amino acid sequence represented by SEQ ID NO: 2.
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8.发明申请公开(公告)号：US20180369299A1
公开(公告)日：2018-12-27
申请号：US16064698
申请日：2016-11-10
发明人： Seong Jun Yoon , Soo Youn Jun , An Sung Kwon , Soon Hye Hwang , Sang Hyeon Kang
IPC分类号： A61K35/76 , A23K20/195 , A61P31/04
CPC分类号： A61K35/76 , A23K20/195 , A23K50/80 , A61P31/04 , C12N7/00 , C12N2795/10221 , C12N2795/10232
摘要： The present invention relates to: Podoviridae bacteriophage Vib-PAP-1 (accession number KCTC 12817BP) which has the capability to specifically destroy Vibrio parahaemolyticus, is characterized by having a genome represented by SEQ ID NO: 1, and is isolated from nature; and a method for preventing and treating Vibrio parahaemolyticus infections, using a composition containing bacteriophage Vib-PAP-1 as an active ingredient.
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9.发明申请公开(公告)号：US20180303885A1
公开(公告)日：2018-10-25
申请号：US15766497
申请日：2016-09-30
发明人： Seong Jun Yoon , Soo Youn Jun , An Sung Kwon , Hyun Min Song , Sang Hyeon Kang
CPC分类号： A61K35/76 , A01N63/00 , A23K10/16 , A23K10/18 , A23K20/158 , A23K20/163 , A23K20/20 , A23K50/80 , A61K8/99 , A61P31/04 , C12N7/00 , C12N2795/10321 , C12N2795/10332 , C12N2795/10371
摘要： The present invention relates to a Siphoviridae bacteriophage Str-INP-1 (Accession NO: KCTC 12687BP) that is isolated from the nature and can kill specifically Streptococcus iniae cells, which has a genome represented by the nucleotide sequence of SEQ. ID. NO: 1, and a method for preventing and treating the infections of Streptococcus iniae using the composition comprising said bacteriophage as an active ingredient.
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10.发明申请METHOD FOR PREVENTION AND TREATMENT OF ESCHERICHIA COLI INFECTIONS USING A BACTERIOPHAGE WITH BROAD ANTIBACTERIAL SPECTRUM AGAINST ESCHERICHIA COLI 有权使用细菌与广谱抗体谱对抗病原菌感染的ESCHERICHIA COLI感染的预防和治疗方法公开(公告)号：US20150322409A1
公开(公告)日：2015-11-12
申请号：US14706325
申请日：2015-05-07
发明人： Seong Jun YOON , Soo Youn Jun , Hyoung Rok Paik , Jee Soo Son , Hye In Jeong , Sang Hyeon Kang
CPC分类号： A61K35/76 , C12N7/00 , C12N2795/00021 , C12N2795/00031 , C12N2795/00032 , C12N2795/10121 , C12N2795/10131 , C12N2795/10132 , C12N2795/10171 , Y02A50/473
摘要： The present invention relates to a composition comprising the bacteriophage EK88P-1 isolated from the nature and having a broad antibacterial spectrum against E. coli as an active ingredient, and a method for preventing and treating E. coli infections using the said composition. The bacteriophage EK88P-1, the active ingredient of the composition of the present invention, has a broad antibacterial spectrum against E. coli and has the genome characteristically composed of the partial nucleotide sequences represented by SEQ. ID. NO: 1˜NO: 25, and also characterized by the bacteriophage belonging to the Myoviridae family according to the morphology that is composed of the major structural proteins in the sizes of approximately 49 kDa, 53 kDa, 94 kDa, and 103 kDa.
摘要翻译： 本发明涉及一种组合物，其包含从性质中分离的噬菌体EK88P-1，并具有对大肠杆菌作为活性成分的广谱抗菌谱，以及使用所述组合物预防和治疗大肠杆菌感染的方法。 噬菌体EK88P-1是本发明组合物的活性成分，具有抗大肠杆菌的广谱抗菌谱，其特征在于由SEQ ID NO：1所示的部分核苷酸序列组成的基因组。 ID。 NO：1〜NO：25，其特征还在于根据由约49kDa，53kDa，94kDa和103kDa大小的主要结构蛋白质组成的形态，属于病毒科的噬菌体。
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