公开(公告)号：US20180087051A1

公开(公告)日：2018-03-29

申请号：US15717807

申请日：2017-09-27

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Audrey Goddard ,  Rodrigo Ortiz ,  Sara Bird ,  Eduardo Morales

IPC: C12N15/10

CPC classification number: C12N15/1082 ,  C12N15/1089 ,  Y02A90/26 ,  C12Q2521/501 ,  C12Q2525/191 ,  C12Q2531/113 ,  C12Q2535/122

Abstract: Embodiments of a method and system for improved microbiome sequencing can include: generating guide RNA complexes for a set of targets corresponding to a set of taxa associated with the microorganism-related condition; processing the biological sample with the gRNA complexes to generate microorganism nucleic acid fragments comprising a set of end regions associated with the set of targets; ligating the set of end regions with a set of adapters sharing an adapter sequence; and amplifying the set of targets based on the ligated set of end regions and a set of primers sharing a primer sequence associated with the adapter sequence.

公开(公告)号：US20180137239A1

公开(公告)日：2018-05-17

申请号：US15707907

申请日：2017-09-18

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Laurens Kraal ,  Francisco Ossandon ,  Juan Pablo Cardenas ,  Elisabeth Bik ,  Audrey Goddard

IPC: G06F19/22 ,  G06F19/24 ,  G16H20/60

CPC classification number: G16B30/00 ,  G16B20/00 ,  G16B40/00 ,  G16H10/40 ,  G16H20/60 ,  G16H50/20 ,  Y02A90/26

Abstract: Embodiments of a system and method for characterizing a panel of conditions associated with a set of taxa related to microorganisms can include a taxonomic database including reference microbiome features for the set of taxa associated with the panel of conditions; a handling operable to collect a container including biological material from a user, the handling system comprising a sequencer system operable to determine a microorganism sequence dataset; and a panel characterization system operable to: determine user microbiome features for the set of taxa for the user based on the microorganism sequence dataset, generate a comparison between the user microbiome features and the reference microbiome features, and determine a panel characterization for the panel of conditions for the user based on the comparison; and a treatment system operable to promote a therapy for a condition of the panel of conditions based on the panel characterization.