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公开(公告)号：US10381117B2
公开(公告)日：2019-08-13
申请号：US15848985
申请日：2017-12-20
申请人： uBiome, Inc.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
IPC分类号： G01N33/48 , G16H50/20 , G06F19/00 , C12Q1/6874 , G16B40/00 , G16B50/00 , G16H10/40 , G06G7/58
摘要： A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10358682B2
公开(公告)日：2019-07-23
申请号：US15636015
申请日：2017-06-28
申请人： uBiome, Inc.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
IPC分类号： G01N33/48 , C12Q1/689 , G16H50/50 , G16B30/00 , G16B40/00 , G16B50/00 , G06F19/00 , G06G7/58
摘要： A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10347367B2
公开(公告)日：2019-07-09
申请号：US15848779
申请日：2017-12-20
申请人： uBiome, Inc.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
IPC分类号： G01N33/48 , G16H10/40 , C12Q1/6883 , G06F19/00 , G16B40/00 , G16B50/00 , G16H50/20 , H01L27/32 , H01L51/00 , H01L51/52 , G06G7/58
摘要： A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10325683B2
公开(公告)日：2019-06-18
申请号：US15644612
申请日：2017-07-07
申请人： uBiome, Inc.
发明人： Zachary Apte , Jessica Richman , Daniel Almonacid
IPC分类号： G01N33/48 , G16H50/20 , G06F19/00 , G16B35/00 , G16B40/00 , G16B50/00 , G16C20/60 , G06G7/58
摘要： A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US20190172555A1
公开(公告)日：2019-06-06
申请号：US16084947
申请日：2016-09-09
申请人： uBiome, Inc.
摘要： Methods, compositions, and systems are provided for detecting one or more a oral health issues by characterizing the microbiome of an individual, monitoring such effects, and/or determining, displaying, or promoting a therapy for the oral health issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and/or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and/or therapy model for dental decay issues and gingivitis issues.
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公开(公告)号：US10290374B2
公开(公告)日：2019-05-14
申请号：US15645062
申请日：2017-07-10
申请人： uBiome, Inc.
发明人： Zachary Apte , Jessica Richman , Daniel Almonacid
IPC分类号： G01N33/48 , G16H50/20 , G06F19/00 , G16B35/00 , G16B40/00 , G16B50/00 , G16C20/60 , G06G7/58
摘要： A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10289805B2
公开(公告)日：2019-05-14
申请号：US15621144
申请日：2017-06-13
申请人： uBiome, Inc.
发明人： Zachary Apte , Jessica Richman , Daniel Almonacid
IPC分类号： G01N33/48 , G06F19/00 , G16B50/00 , C12Q1/68 , C12Q1/6883 , C12Q1/689 , G16H50/20 , G16H20/10 , G16B99/00 , G16B5/00 , G06G7/58
摘要： A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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8.发明授权公开(公告)号：US10268803B2
公开(公告)日：2019-04-23
申请号：US15621168
申请日：2017-06-13
申请人： uBiome, Inc.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
摘要： A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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公开(公告)号：US10255990B2
公开(公告)日：2019-04-09
申请号：US15811544
申请日：2017-11-13
申请人： uBiome, Inc.
发明人： Zachary Apte , Jessica Richman , Daniel Almonacid , Rodrigo Ortiz
IPC分类号： G06F19/22 , C12N15/10 , C12Q1/6869 , G16B30/00 , C40B50/06
摘要： Embodiments of a method and/or system for improving fragment assembly and/or sequence identification includes: collecting a sample including a set of nucleic acid components associated with a set of microorganisms; generating a set of tagged sequence fragments; amplifying the set of tagged sequence fragments and sequencing the set of tagged sequence fragments; based upon the set of identifier tags, generating a set of branched assemblies of candidate sequence fragments, wherein each of the set of branched assemblies includes a set of ordered nodes and a set of branches distributed across the set of nodes; implementing a threshold criterion to reduce the set of branched assemblies to a set of branch-reduced assemblies; and identifying a set of sequences corresponding to the set of branch-reduced assemblies and/or generating an analysis informative of the set of microorganisms associated with the sample.
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公开(公告)号：US10242160B2
公开(公告)日：2019-03-26
申请号：US15606874
申请日：2017-05-26
申请人： uBiome, Inc.
发明人： Zachary Apte , Jessica Richman , Daniel Almonacid
IPC分类号： G01N33/48 , G06F19/00 , C12Q1/68 , C12Q1/6883 , C12Q1/689 , G06F19/10 , G06F19/28 , G06F19/12 , G16H50/20 , G16H20/10 , G06G7/58
摘要： A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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