公开(公告)号：US20190078085A1

公开(公告)日：2019-03-14

申请号：US16125619

申请日：2018-09-07

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Eduardo Morales ,  Rodrigo Ortiz ,  Nicolas Ordenes ,  Juan Jimenez ,  Cristian Bravo ,  Natalia Scioscia ,  Eduardo Olivares ,  Luis Leon ,  Paulo Covarrubias ,  Felipe Sepulveda ,  Felipe Melis

IPC: C12N15/10 ,  C12N15/11 ,  C12Q1/6806 ,  C12Q1/6811 ,  C12Q1/686 ,  C12Q1/6876 ,  C12N15/66 ,  C12Q1/6855 ,  C12Q1/6869

Abstract: Embodiments of a method and/or system, such as for preparation of a normalized library for sequencing such as next-generation sequencing, can include one or more of: generating one or more normalized amplicon libraries; generating one or more normalized microbial community-associated libraries; and/or generating one or more normalized combined sequence libraries associated with amplicon-associated sequencing and microbial community-associated sequencing.

公开(公告)号：US20190078142A1

公开(公告)日：2019-03-14

申请号：US16115542

申请日：2018-08-28

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Elisabeth Bik ,  Sara W. Bird ,  Luis E. Leon ,  Pamela A. Nieto ,  Victor Alegria-Mera ,  Cristian Bravo ,  Juan P. Cardenas ,  Paulo Covarrubias ,  Sarah L. Gupta ,  Kira Harman ,  Juan Jimenez ,  Felipe Melis-Arcos ,  Camila F. Navas ,  Harold Nunez ,  Eduardo Olivares ,  Nicolas Ordenes-Aenishanslins ,  Francisco J. Ossandon ,  Ignacio Varas ,  Patricia Vera-Wolf ,  Donna Marie B. Hongo ,  Laurens Kraal ,  Nathaniel A. Walton ,  Amanda Morton ,  Juan P. Bustamante ,  Kwasi Addae ,  Graham Gass ,  Katia Soto-Liebe ,  Juan A. Ugalde ,  Eduardo H. Morales ,  Daniel Almonacid ,  Jessica Richman

IPC: C12Q1/689 ,  C12Q1/04 ,  C12Q1/70

Abstract: Embodiments of a method and/or system for characterizing one or more female reproductive system-related conditions can include determining a microorganism dataset associated with a set of subjects; and/or performing a characterization process associated with the one or more female reproductive system-related conditions, based on the microorganism dataset, where performing the characterization process can additionally or alternatively include performing a female reproductive system-related characterization process for the one or more female reproductive system-related conditions, and/or determining one or more therapies.

公开(公告)号：US20180362967A1

公开(公告)日：2018-12-20

申请号：US16013858

申请日：2018-06-20

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Juan Jimenez ,  Rodrigo Ortiz ,  Eduardo Morales ,  Paulo Covarrubias ,  Eduardo Olivares ,  Nicolas Ordenes ,  Luis Leon

IPC: C12N15/10

Abstract: Embodiments of a method 100 and/or system 200 or library preparation for sequencing associated with microorganisms can include: preparing a set of unique molecular identifier (UMI)-based molecules associated with one or more targets; preparing a set of sequencing-based primers; generating a set of tagged target molecules based on the set of UMI-based molecules and one or more samples associated with the one or more targets; and/or generating a set of sequencing-ready tagged target molecules based on the tagged target molecules and the set of sequencing-based primers.