公开(公告)号：US20190050525A1

公开(公告)日：2019-02-14

申请号：US16103830

申请日：2018-08-14

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Valeria Marquez ,  Ingrid Araya ,  Melissa Alegria ,  Mario Saavedra ,  Luis Gomez ,  Janyra Espinoza ,  Javier Gimpel ,  Eduardo Morales ,  Rodrigo Ortiz

IPC: G06F19/16 ,  G06F19/12

Abstract: Embodiments of a method and/or system can include administering, to a patient with one or more conditions associated with at least one of TMA, TMAO, and/or derivatives thereof, a therapeutically effective amount of a compound for affecting inhibiting one or more CutC enzymes and/or CntA enzymes associated with microorganisms from at least one taxon from a set of microorganism taxa.

公开(公告)号：US20180311310A1

公开(公告)日：2018-11-01

申请号：US15914925

申请日：2018-03-07

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Melissa Alegria ,  Valeria Marquez ,  Eduardo Morales ,  Rodrigo Ortiz ,  Janet Torres ,  Paulo Covarrubias ,  Javier Gimpel ,  Ingrid Araya

IPC: A61K38/16

CPC classification number: A61K38/16

Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.