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    PYRIDOMORPHINANS, PYRIDAZINOMORPHINANS AND USE THEREOF
    2.
    发明申请
    PYRIDOMORPHINANS, PYRIDAZINOMORPHINANS AND USE THEREOF 有权
    吡咯烷酮，吡咯烷酮和其用途

    公开(公告)号：US20090239892A1

    公开(公告)日：2009-09-24

    申请号：US12407000

    申请日：2009-03-19

    申请人： Subramaniam Ananthan ,  Richard B. Rothman ,  Edward J. Bilsky ,  Frank Porreca

    发明人： Subramaniam Ananthan ,  Richard B. Rothman ,  Edward J. Bilsky ,  Frank Porreca

    IPC分类号： A61K31/485 ,  C07D491/18 ,  A61P25/00

    CPC分类号： C07D491/18

    摘要： Compounds represented by the formula:wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R′ is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to μ agonists.

    摘要翻译： 由下式表示的化合物：其中R是C 1-6烷基; C4-6环烷基烷基; 或C 3-6烯基; R'是H或C 1-6烷基; X是H或OH; Y是烷基，环烷基，芳基，杂芳基，芳基烷基或芳酰基; Z为CH或N; 条件是X为H，当Z为CH且R为C 4环烷基烷基或C 4链烯基时; 其前药; 及其药学上可接受的盐。 上述化合物可用作治疗疼痛的止痛剂; 作为免疫调节剂，调节滥用药物的行为效应，调节对mu激动剂的耐受性和依赖性的发展。

    Embedded piezoelectric microcantilever sensors
    5.
    发明授权
    Embedded piezoelectric microcantilever sensors 有权
    嵌入式压电微悬臂传感器

    公开(公告)号：US07168294B2

    公开(公告)日：2007-01-30

    申请号：US11004555

    申请日：2004-12-02

    申请人： Timothy L. Porter ,  Michael P. Eastman

    发明人： Timothy L. Porter ,  Michael P. Eastman

    IPC分类号： G01N7/00

    CPC分类号： G01N29/022 ,  G01N29/2475 ,  G01N33/54386 ,  G01N2291/0427

    摘要： An apparatus and method for sensing chemical and/or biological analytes includes a deflectable arm of a microcantilever at least partially embedded within a sensing element. A gaseous or liquid medium which may include the analyte being detected is introduced to the sensing element. The sensing element undergoes volumetric expansion or contraction in the presence of the analyte sought to be detected, typically by adsorbing the analyte. The volumetric change of the sensing element causes the deflectable arm to deflect. The deflectable arm includes at least one measurable physical property which changes when the arm deflects. Detecting means are provided to measure the change in the physical property to determine the presence and amount of analyte present. An array of microcantilevers in which each microcantilever is dedicated to detecting a particular analyte which may be included in the medium, is also provided.

    摘要翻译： 用于感测化学和/或生物分析物的装置和方法包括至少部分地嵌入感测元件内的微悬臂梁的可偏转臂。 可将包括待检测分析物的气体或液体介质引入感测元件。 通常通过吸附分析物，感测元件在待测物质存在下经历体积膨胀或收缩。 感测元件的体积变化导致可偏转臂偏转。 可偏转臂包括当臂挠曲时改变的至少一个可测量的物理特性。 提供检测手段以测量物理性质的变化以确定存在的分析物的存在和量。 还提供了一组微悬臂梁，其中每个微悬臂梁专用于检测可包括在介质中的特定分析物。

    Ultrapure water treatment system
    6.
    发明授权
    Ultrapure water treatment system 失效
    超纯水处理系统

    公开(公告)号：US5302356A

    公开(公告)日：1994-04-12

    申请号：US845988

    申请日：1992-03-04

    申请人： Farhang F. Shadman ,  Robert A. Governal

    发明人： Farhang F. Shadman ,  Robert A. Governal

    IPC分类号： B01J19/12 ,  C02F1/32 ,  C02F1/72

    CPC分类号： C02F1/325 ,  B01J19/123 ,  C02F1/725 ,  C02F2103/04 ,  Y10S210/90 ,  Y10S422/905

    摘要： An ultrapure water treatment system is provided by the present invention. e system comprises a housing, a water supply means including a water inlet and a water outlet communicating with the housing and defining a path of travel of the water from said inlet to said outlet, irradiation means for irradiating water with 185 nm UV light positioned within the housing, and a catalytic filter positioned in the path of travel of the water. The catalytic filter comprises a non-polymeric porous material having a photoactive catalyst thereon. Exemplary photoactive catalysts include TiO.sub.2, ZnO, WO.sub.3, SnO.sub.2, CU.sub.2 O, and CdSe.

    摘要翻译： 本发明提供超纯水处理系统。 该系统包括壳体，供水装置，其包括进水口和与该壳体连通的出水口，并且限定水从所述入口到所述出口的行进路径，照射装置，用于照射位于 壳体和位于水的行进路径中的催化过滤器。 催化过滤器包括其上具有光活性催化剂的非聚合多孔材料。 示例性的光活性催化剂包括TiO 2，ZnO，WO 3，SnO 2，Cu 2 O和CdSe。

    Phyllanthostatin A
    7.
    发明授权
    Phyllanthostatin A 失效
    叶绿素A

    公开(公告)号：US4997817A

    公开(公告)日：1991-03-05

    申请号：US467683

    申请日：1990-01-19

    申请人： George R. Pettit

    发明人： George R. Pettit

    IPC分类号： C07H13/08 ,  C07H13/10

    CPC分类号： C07H13/08 ,  C07H13/10

    摘要： An unusal cytostatic (PS ED.sub.50 4 ug/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and is herein designated Phyllanthostatin A. Separation of a methanol extract of the root by size exclusion chromatography, high speed countercurrent distribution and semi-preparative hplc afforded glycoside in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin-B. The structure of the lignan glycoside, determined by hrfabms and 2D nmr spectroscopy, is: ##STR1##

    摘要翻译： 已经从中美洲的叶子叶茶叶中分离出一种未分解的细胞生长抑制（PS ED 50 4ug / ml）木脂素酯，在此称为叶绿素抑制素A.根据大小排阻色谱法，高速逆流分布和半 - 制备型hplc以0.007％的产率提供糖苷。 在溶液中，叶绿素A缓慢转化成法洛替丁B。 通过hrfabms和2D nmr光谱测定的木糖苷的结构是：