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1.发明授权Enhanced moisture barrier immediate release film coating systems and substrates coated therewith 有权增强的防潮快速脱膜膜涂层系统和涂覆的基材公开(公告)号：US09028862B2
公开(公告)日：2015-05-12
申请号：US14156060
申请日：2014-01-15
申请人： BPSI Holdings, LLC.
发明人： Thomas P. Farrell , Jason Teckoe
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/2846 , A61K47/02
摘要： The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和具有改善的防潮性能的其它可口服摄取的底物的立即释放膜包衣系统。 膜涂层系统可以直接施加到基底上，或者在基底涂覆有底涂层之后。 在优选的方面，防潮膜涂层被制备为含有聚乙烯醇，具有pH依赖性溶解度的聚合物，增塑剂，助流剂和任选的防粘剂，碱化剂和颜料的干粉混合物。 还公开了含有粉末混合物的水性悬浮液的薄膜包衣组合物，将涂料施加到基材和涂布的基材上的方法。
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2.发明申请ENHANCED MOISTURE BARRIER IMMEDIATE RELEASE FILM COATING SYSTEMS AND SUBSTRATES COATED THEREWITH 有权增强水分阻隔膜立即释放薄膜涂层系统及其涂层公开(公告)号：US20100291183A1
公开(公告)日：2010-11-18
申请号：US12769188
申请日：2010-04-28
申请人： Thomas P. FARRELL , Jason TECKOE
发明人： Thomas P. FARRELL , Jason TECKOE
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/2846 , A61K47/02
摘要： The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和具有改善的防潮性能的其它可口服摄取的底物的立即释放膜包衣系统。 膜涂层系统可以直接施加到基底上，或者在基底涂覆有底涂层之后。 在优选的方面，防潮膜涂层被制备为含有聚乙烯醇，具有pH依赖性溶解度的聚合物，增塑剂，助流剂和任选的防粘剂，碱化剂和颜料的干粉混合物。 还公开了含有粉末混合物的水性悬浮液的薄膜包衣组合物，将涂料施加到基材和涂布的基材上的方法。
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3.发明申请FILM COATINGS CONTAINING FINE PARTICLE SIZE DETACKIFIERS AND SUBSTRATES COATED THEREWITH 有权包含精细粒度分离器的薄膜涂层和包覆的基板公开(公告)号：US20100291159A1
公开(公告)日：2010-11-18
申请号：US12769197
申请日：2010-04-28
申请人： Thomas P. FARRELL , Jason TECKOE , Barry FRIEND , Scott GULIAN
发明人： Thomas P. FARRELL , Jason TECKOE , Barry FRIEND , Scott GULIAN
摘要： The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a fine particle size detackifier. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is either polyvinyl alcohol or a copolymer of polyvinyl alcohol. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压制片剂和其它含有细颗粒尺寸防粘剂的可口服摄取底物的薄膜包衣组合物。 膜涂层组合物可以直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是聚乙烯醇或聚乙烯醇的共聚物。 还公开了包含本发明的薄膜涂料组合物的水性悬浮液，将涂料施涂到基材和涂布的基材本身上的方法。
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公开(公告)号：US20240024247A1
公开(公告)日：2024-01-25
申请号：US18260524
申请日：2022-01-10
申请人： BPSI HOLDINGS LLC
发明人： Thomas MEHAFFEY , Manish GHIMIRE
IPC分类号： A61K9/28
CPC分类号： A61K9/2866 , A61K9/282
摘要： The present invention is directed film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a water-soluble polymer, an opacifying agent such as, calcium carbonate or starch, and isomalt. The film coating compositions can be in the form of a fully formulated dry blend or as an aqueous suspension which can be applied either directly to a substrate or after the substrate has been coated with a subcoat. Oral substrates such as tablets coated with the film coating compositions are also disclosed and have high opacity and overall excellent appearance.
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公开(公告)号：US20190314286A1
公开(公告)日：2019-10-17
申请号：US16369251
申请日：2019-03-29
申请人： BPSI Holdings LLC
发明人： Raxitkumar Y. Mehta , George Reyes , Jason Teckoe , Daniel To
摘要： The present invention includes acidifying film coating compositions containing a polymer and an acidic component for use on orally-ingestible substrates such as tablets and the like. The acidifying coating compositions can be applied as an aqueous dispersion to an enteric-coated substrate to increase the disintegration resistance to aqueous media of up to pH 5.0. In preferred aspects, the acidic component is citric acid, lactic acid, stearic acid or mixtures thereof. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous dispersions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
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6.发明授权Delayed release film coatings containing calcium silicate and substrates coated therewith 有权含有硅酸钙的延迟释放膜涂层和其上涂覆的基材公开(公告)号：US09233074B2
公开(公告)日：2016-01-12
申请号：US14189508
申请日：2014-02-25
申请人： BPSI Holdings, LLC.
IPC分类号： A61K9/28
CPC分类号： A61K9/2813 , A61K9/2846 , A61K9/2886
摘要： The present invention includes pH dependent, dry film coating compositions containing calcium silicate for use on orally-ingestible substrates such as tablets and the like. The film coating compositions can be applied as an aqueous suspension either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is either an enteric or reverse-enteric polymer. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous suspensions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译： 本发明包括pH依赖性，含有硅酸钙的干膜包衣组合物，用于口服可摄取的底物如片剂等。 膜涂料组合物可以作为水性悬浮液直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是肠溶或反肠溶性聚合物。 还公开了制备干膜涂层的方法，制备相应的水性悬浮液的方法，将涂层施加到基材和涂布的基材本身上的方法。
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公开(公告)号：US10232045B2
公开(公告)日：2019-03-19
申请号：US15660250
申请日：2017-07-26
申请人： BPSI Holdings, LLC
发明人： Jeffrey R. Gimbel , Daniel To , Jason Teckoe
摘要： The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a water-soluble polymer and guar gum. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the water-soluble polymer is a cellulosic or vinyl polymer. Aqueous suspensions containing the inventive film coating compositions and the coated substrates themselves are also disclosed. The resulting coated substrates have relatively low coefficients of static and dynamic friction on wet surfaces rendering them easier to swallow than prior art compositions.
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8.发明授权公开(公告)号：US09789067B2
公开(公告)日：2017-10-17
申请号：US15332319
申请日：2016-10-24
申请人： BPSI Holdings, LLC
发明人： Jason Teckoe , Bradley J. Prusak , Jeffrey R. Gimbel , Daniel To
CPC分类号： A61K9/282 , A61K9/2813 , A61K9/284 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to immediate release film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain medium chain glycerides as detackifiers. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is polyvinyl alcohol and the medium chain glycerides are mixtures of caprylic (8 carbon chain) and capric (10 carbon chain) mono- and diesters of glycerin. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
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9.发明申请ENHANCED MOISTURE BARRIER IMMEDIATE RELEASE FILM COATING SYSTEMS AND SUBSTRATES COATED THEREWITH 审中-公开增强水分阻隔膜立即释放薄膜涂层系统及其涂层公开(公告)号：US20140128477A1
公开(公告)日：2014-05-08
申请号：US14156060
申请日：2014-01-15
申请人： BPSI Holdings, LLC.
发明人： Thomas P. Farrell , Jason TECKOE
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/2846 , A61K47/02
摘要： The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和具有改善的防潮性能的其它可口服摄取的底物的立即释放膜包衣系统。 膜涂层系统可以直接施加到基底上，或者在基底涂覆有底涂层之后。 在优选的方面，防潮膜涂层被制备为含有聚乙烯醇，具有pH依赖性溶解度的聚合物，增塑剂，助流剂和任选的防粘剂，碱化剂和颜料的干粉混合物。 还公开了含有粉末混合物的水性悬浮液的薄膜包衣组合物，将涂料施加到基材和涂布的基材上的方法。
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10.发明授权Film coatings containing fine particle size detackifiers and substrates coated therewith 有权含有细颗粒尺寸的粘合剂和涂覆的基材的薄膜涂层公开(公告)号：US08388983B2
公开(公告)日：2013-03-05
申请号：US12769197
申请日：2010-04-28
申请人： Thomas P. Farrell , Jason Teckoe , Barry Friend , Scott Gulian
发明人： Thomas P. Farrell , Jason Teckoe , Barry Friend , Scott Gulian
摘要： The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a fine particle size detackifier. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is either polyvinyl alcohol or a copolymer of polyvinyl alcohol. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压制片剂和其它含有细颗粒尺寸防粘剂的可口服摄取底物的薄膜包衣组合物。 膜涂层组合物可以直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是聚乙烯醇或聚乙烯醇的共聚物。 还公开了包含本发明的薄膜涂料组合物的水性悬浮液，将涂料施涂到基材和涂布的基材本身上的方法。
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