-
公开(公告)号：US06037120A
公开(公告)日：2000-03-14
申请号：US542142
申请日：1995-10-12
申请人： Steven Albert Benner
发明人： Steven Albert Benner
摘要： The disclosure describes a new method for intermolecular recognition between two molecules, where complementary oligonucleotide strands bind in aqueous solution, where these strains contain non-standard nucleobases that can pair to fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a "non-standard base pair").
摘要翻译： 本公开描述了两种分子之间的分子间识别的新方法，其中互补的寡核苷酸链在水溶液中结合，其中这些菌株含有可以配对以适应沃森 - 克里克几何的非标准核碱基，因为它们涉及单环六元环配对 与由六元环稠合的五元环组成的稠合双环杂环体系，杂环相对于彼此和相对于骨架链的取向类似于在DNA和RNA中发现的杂环，但是具有 将碱基对保持的氢键的模式与AT和GC碱基对（“非标准碱基对”）中发现的不同。
-
公开(公告)号：US5965364A
公开(公告)日：1999-10-12
申请号：US775402
申请日：1996-12-31
申请人： Steven Albert Benner
发明人： Steven Albert Benner
CPC分类号： C07H21/00 , C12N15/102 , C12P19/34 , C12Q1/68 , Y10T436/143333
摘要： Improvements are provided for methods for selecting in vitro compositions of matter that serve as ligands and catalysts. Also provided are novel nucleoside analogs that expand the structural diversity of oligonucleotides and their analogs.
摘要翻译： 提供用于选择用作配体和催化剂的物质的体外组合物的方法的改进。 还提供了扩增寡核苷酸及其类似物的结构多样性的新型核苷类似物。
-
3.发明授权
公开(公告)号：US6140496A
公开(公告)日：2000-10-31
申请号：US775401
申请日：1996-12-31
申请人： Steven Albert Benner
发明人： Steven Albert Benner
CPC分类号： C07H21/00 , C12N15/102 , C12P19/34 , C12Q1/68 , Y10S977/80 , Y10S977/898 , Y10S977/915
摘要： The disclosure describes building blocks for preparing oligonucleotides carrying non-standard nucleobases that can pair with complementary non-standard nucleobases so as to fit the Watson-Crick geometry, in that the resulting base pair joins a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six member ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a "non-standard base pair").
摘要翻译： 本公开描述了用于制备携带非互补非标准核碱基的非标准核碱基的寡核苷酸的构建块，以便适应沃森 - 克里克几何，因为得到的碱基对与稠合的双环杂环连接单环六元环配对 环系统由与六元环稠合的五元环组成，杂环相对于彼此和相对于骨架链的取向类似于DNA和RNA中发现的，但具有氢键的模式， 碱基对与AT和GC碱基对（“非标准碱基对”）中发现的不同。
-
4.发明授权
公开(公告)号：US6001983A
公开(公告)日：1999-12-14
申请号：US375132
申请日：1995-01-17
申请人： Steven Albert Benner
发明人： Steven Albert Benner
CPC分类号： C07H21/00 , C12N15/102 , C12P19/34
摘要： The disclosure describes new compositions of matter that are analogs of DNA and RNA containing heterocyclic bases that can form base pairs that fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but where these base pairs are joined by a pattern of hydrogen bonds different from that found in the AT and GC base pairs (a "non-standard base pair").
摘要翻译： 本公开描述了作为包含杂环碱基的DNA和RNA的类似物的新组合物，其可以形成适合沃森 - 克里克几何的碱基对，因为它们涉及与五元组成的稠合双环杂环体系的单环六元环配对 与六元环稠合的成员环，其杂环相对于彼此的方向和相对于骨架链的取向类似于在DNA和RNA中发现的那些，但是其中这些碱基对通过不同的氢键的图案连接 来自于AT和GC碱基对（“非标准碱基对”）。
-
公开(公告)号：US5958702A
公开(公告)日：1999-09-28
申请号：US386521
申请日：1995-02-06
申请人： Steven Albert Benner
发明人： Steven Albert Benner
IPC分类号： C07B61/00 , G01N33/543 , G01N33/53 , A61K38/00
CPC分类号： G01N33/54306 , C40B40/00
摘要： This invention provides a method for preparing molecules that bind to a preselected receptor, whereby the receptor itself acts as an agent for either joining two ligand fragments to form a composite, tight binding ligand, or selects a composite ligand from a mixture in solution where ligand fragments are being joined and unjoined reversibly under equilibrium conditions.
摘要翻译： 本发明提供了一种制备结合预选受体的分子的方法，其中受体本身作为连接两个配体片段以形成复合物，紧密结合配体或从溶液中的混合物中选择复合配体的试剂，其中配体 碎片在平衡条件下可逆地连接和不连接。
-
公开(公告)号：US5958784A
公开(公告)日：1999-09-28
申请号：US857224
申请日：1992-03-25
申请人： Steven Albert Benner
发明人： Steven Albert Benner
CPC分类号： G01N33/6803
摘要： A method is presented for predicting the folded structure of proteins that comprises obtaining an alignment of the sequences of a set of homologous proteins, using patterns of conservation and variation of the sequence between proteins with clearly defined evolutionary relationships to assign positions in the alignment to the surface of the folded structure, the inside of the folded structure, active site, or parsing segments, assigning secondary structures by identifying periodicity in said assignments, and then assembling the secondary structural units into a globular form using distance constraints imposed by disulfide bridges, active site assignments, and covariation analysis.
摘要翻译： 提出了一种用于预测蛋白质的折叠结构的方法，其包括使用一组同源蛋白质的序列的比对，使用具有明确定义的进化关系的蛋白质之间的序列的保守和变化的模式来指定对齐位置 折叠结构的内部，折叠结构的内部，活动位置或解剖段，通过识别所述分配中的周期性来分配二级结构，然后使用由二硫键施加的距离约束将二次结构单元组装成球形，活动 站点分配和协变分析。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.018 秒)
