利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

148 条记录 (耗时 0.081 秒)

    SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION
    1.
    发明申请
    SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION 审中-公开
    作为ABETA蛋白质生产的抑制剂的替代的LACTAMS

    公开(公告)号：US20100048541A1

    公开(公告)日：2010-02-25

    申请号：US12561420

    申请日：2009-09-17

    申请人： Qi HAN ,  Hong Liu ,  Richard E. Olson ,  Michael G. Yang

    发明人： Qi HAN ,  Hong Liu ,  Richard E. Olson ,  Michael G. Yang

    IPC分类号： A61K31/5513 ,  C07D243/24 ,  C07D401/04

    CPC分类号： C07D223/12 ,  C07D223/18 ,  C07D243/12 ,  C07D243/24 ,  C07D401/04

    摘要： This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    摘要翻译： 本发明涉及式（I）的新型内酰胺：具有药物和生物影响性质，其药物组合物和使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ的生成，从而起到防止淀粉样蛋白的神经沉积的形成的作用。 更具体地说，本发明涉及与阿尔茨海默病和唐氏综合征等淀粉样蛋白生成相关的神经障碍的治疗。

    Succinoylamino lactams as inhibitors of a-β protein production
    3.
    发明授权
    Succinoylamino lactams as inhibitors of a-β protein production 失效
    琥珀酰氨基内酰胺作为α-β蛋白生产的抑制剂

    公开(公告)号：US07507815B2

    公开(公告)日：2009-03-24

    申请号：US11950399

    申请日：2007-12-04

    申请人： Richard E. Olson ,  Thomas P. Maduskuie ,  Lorin Andrew Thompson

    发明人： Richard E. Olson ,  Thomas P. Maduskuie ,  Lorin Andrew Thompson

    IPC分类号： C07D243/24

    CPC分类号： C07D401/06 ,  C07D223/12 ,  C07D243/24 ,  C07D401/10 ,  C07D405/12

    摘要： This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    摘要翻译： 本发明涉及具有药物和生物影响性质的新型内酰胺，其药物组合物和使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。 更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

    SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF AB PROTEIN PRODUCTION
    4.
    发明申请
    SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF AB PROTEIN PRODUCTION 审中-公开
    作为AB蛋白生产抑制剂的苯甲酰胺苯甲酸

    公开(公告)号：US20090069293A1

    公开(公告)日：2009-03-12

    申请号：US12254431

    申请日：2008-10-20

    申请人： Richard E. Olson

    发明人： Richard E. Olson

    IPC分类号： A61K31/55 ,  C07D223/18

    CPC分类号： C07D223/16 ,  C07D243/12 ,  C07D243/14 ,  C07D243/24 ,  C07D401/04

    摘要： This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    摘要翻译： 本发明涉及具有式（I）的新型内酰胺：其药物组合物及其使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。 更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

    LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
    5.
    发明申请
    LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION 审中-公开
    作为Abeta蛋白生产抑制剂的循环成分取代的LACTAMS

    公开(公告)号：US20090062256A1

    公开(公告)日：2009-03-05

    申请号：US12257809

    申请日：2008-10-24

    申请人： Richard E. Olson

    发明人： Richard E. Olson

    IPC分类号： A61K31/55 ,  C07D243/24 ,  C07D487/04 ,  A61P25/28 ,  C07D487/14 ,  A61K31/5513

    CPC分类号： C07D223/12 ,  C07D223/16 ,  C07D223/18 ,  C07D243/14 ,  C07D243/24 ,  C07D243/26

    摘要： This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    摘要翻译： 本发明涉及具有式（I）的新型内酰胺：其药物组合物及其使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。 更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

    Succinoylamino benzodiazepines as inhibitors of Aβ protein production
    6.
    发明授权
    Succinoylamino benzodiazepines as inhibitors of Aβ protein production 有权
    琥珀酰氨基苯二氮卓类作为Abeta蛋白生产的抑制剂

    公开(公告)号：US07456172B2

    公开(公告)日：2008-11-25

    申请号：US11331791

    申请日：2006-01-13

    申请人： Richard E. Olson

    发明人： Richard E. Olson

    IPC分类号： A61P25/28 ,  A61K31/55 ,  C07D243/12

    CPC分类号： C07D223/16 ,  C07D243/12 ,  C07D243/14 ,  C07D243/24 ,  C07D401/04

    摘要： This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

    摘要翻译： 本发明涉及具有式（I）的新型内酰胺：其药物组合物及其使用方法。 这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。 更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

    Selective estrogen receptor modulators
    9.
    发明授权
    Selective estrogen receptor modulators 有权
    选择性雌激素受体调节剂

    公开(公告)号：US07323587B2

    公开(公告)日：2008-01-29

    申请号：US11152891

    申请日：2005-06-15

    申请人： Robert F. Kaltenbach ,  Simon P. Robinson ,  George L. Trainor

    发明人： Robert F. Kaltenbach ,  Simon P. Robinson ,  George L. Trainor

    IPC分类号： A61K31/192 ,  C07C57/50

    CPC分类号： C07D257/04 ,  C07C51/487 ,  C07C57/50 ,  C07C59/54 ,  C07C59/72 ,  C07C69/618 ,  C07C69/734 ,  C07C255/34 ,  C07C311/51 ,  C07C2601/10 ,  C07C2602/10 ,  C07C2602/12 ,  C07D277/80 ,  C07D311/58 ,  C07D333/34

    摘要： The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for treating estrogen stimulated diseases in mammals including, but not limited to, for example, breast, uterine, ovarian, prostate and colon cancer; osteoporosis; endometriosis; uterine fibroid; Alzheimer's disease; macular degeneration; urinary incontinence; and type II diabetes, as well as, pharmaceutical compositions comprising at least one compound of the present invention.

    摘要翻译： 本发明特别提供三苯基乙烯衍生物，例如3- {4- [6-（3-甲氧基 - 苯基）-8,9-二氢-7H-苯并环庚烯-5-基] - 苯基} - 丙烯酸 ，作为选择性雌激素受体调节剂。 还提供了用于治疗哺乳动物中雌激素刺激的疾病的方法，包括但不限于例如乳腺癌，子宫癌，卵巢癌，前列腺癌和结肠癌; 骨质疏松症 子宫内膜异位症 子宫肌瘤 阿尔茨海默氏病; 黄斑变性; 尿失禁 和II型糖尿病，以及包含至少一种本发明化合物的药物组合物。